Recombinant Human WEE1 Protein (M291-K575), His tagged
Cat.No. : | WEE1-0060H |
Product Overview : | Recombinant Human 8His-TEV-(G)-Wee1(M291-K575) Protein was expressed in Insect cell. |
- Specification
- Gene Information
- Related Products
Description : | Acts as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDK1 before the onset of mitosis by mediating phosphorylation of CDK1 on 'Tyr-15'. Specifically phosphorylates and inactivates cyclin B1-complexed CDK1 reaching a maximum during G2 phase and a minimum as cells enter M phase. Phosphorylation of cyclin B1-CDK1 occurs exclusively on 'Tyr-15' and phosphorylation of monomeric CDK1 does not occur. Its activity increases during S and G2 phases and decreases at M phase when it is hyperphosphorylated. A correlated decrease in protein level occurs at M/G1 phase, probably due to its degradation. |
Source : | Insect cell |
Species : | Human |
Tag : | His |
Form : | Liquid |
Protein Length : | M291-K575 |
Endotoxin : | < 0.01 EU per μg of the protein |
Purity : | 90% |
Stability : | Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade. |
Storage : | Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Storage Buffer : | Supplied as sterile 50 mM Tris-HCl (pH7.5), 200 mM NaCl, 20% glycerol |
Shipping : | It is shipped out with blue ice. |
Gene Name : | WEE1 WEE1 homolog (S. pombe) [ Homo sapiens (human) ] |
Official Symbol : | WEE1 |
Synonyms : | WEE1; WEE1 homolog (S. pombe); wee1+ (S. pombe) homolog; wee1-like protein kinase; wee1A kinase; WEE1+ homolog; WEE1A; WEE1hu; FLJ16446; DKFZp686I18166; |
Gene ID : | 7465 |
mRNA Refseq : | NM_001143976 |
Protein Refseq : | NP_001137448 |
MIM : | 193525 |
UniProt ID : | P30291 |
Products Types
◆ Recombinant Protein | ||
WEE1-14H | Recombinant Human WEE1 Protein (215-646, end), N-FLAG tagged | +Inquiry |
WEE1-707H | Recombinant Human WEE1 Protein, GST-HIS6-tagged | +Inquiry |
WEE1-15H | Active Recombinant Human WEE1 Protein (Q36-Y432), N-GST-6×His tagged | +Inquiry |
Wee1-6992M | Recombinant Mouse Wee1 Protein, Myc/DDK-tagged | +Inquiry |
WEE1-001H | Recombinant Human WEE1 Protein, GST-tagged | +Inquiry |
◆ Lysates | ||
WEE1-1930HCL | Recombinant Human WEE1 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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