YWHAZ
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Official Full Name
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
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Overview
14-3-3 proteins are highly conserved proteins which play a role in both signal transduction and progression through the cell cycle by binding to and regulating several different proteins. 14-3-3 proteins activate tyrosine and tryptophan hydroxylases and protein kinase C. They mediate signal transduction by binding to phosphoserine-containing proteins. There are at least 7 mammalian isoforms: alpha, beta, gamma, delta, epsilon, zeta, and eta. An eighth subtype, termed theta has been found in rat brain. The 14-3-3 proteins exists in vitro and in vivo as either homo- or heterodimers which interact via their N-terminal domains and are subject to phosphorylation by protein kinase C. 14-3-3 proteins are localized in the cytoplasm of neurons in the cerebral cortex and are axonally transported to the nerve terminals. They may be present at lower levels in various other eukaryotic tissues. Northern blot analysis has shown expression of the eta chain in cultured cell lines derived from various tumors. -
Synonyms
YWHAZ; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide; tyrosine 3 monooxygenase/tryptophan 5 monooxygenase activation protein, delta polypeptide , YWHAD; 14-3-3 protein zeta/delta; 14 3 3 delta; 14 3 3 zeta; KCIP;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- HEK293T
- Insect Cell
- Mammalian Cell
- Mammalian cells
- Yeast
- C
- Myc
- DDK
- Flag
- GST
- His
- His (Fc)
- Avi
- SUMO
- N/A
- N
- T7|His
- Involved Pathway
- Protein Function
- Interacting Protein
- YWHAZ Related Articles
- YWHAZ Related Research Area
YWHAZ involved in several pathways and played different roles in them. We selected most pathways YWHAZ participated on our site, such as Cell cycle, Oocyte meiosis, PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with YWHAZ were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Cell cycle | CDC25A;SMARCA5;UIMC1;SMC1AL;CEP164;CLASP1;SKP1;RAD17;NCAPD3 |
Oocyte meiosis | RPS6KA3A;CDC25C;PKMYT1;CALM3;MOS;RPS6KA6;CDK1;PRKACB;YWHAQA |
PIK-Akt signaling pathway | MAP2K1;IBSP;PCK1;FGF11;BCL2L1;HRAS;MTCP1;FGF7;EIF4E2 |
Hippo signaling pathway | WNT10B;SMAD3;FZD6;STK3;FZD1;FZD2;SNAI2;APC2;WNT8B |
Pathogenic Escherichia coli infection | TUBB1;WASL;NCL;ROCK1;TUBB6;ARHGEF2;ITGB1;TUBA1A;TUBA3D |
Hepatitis B | IRF3;IFN-a;IFNA8;TLR2;IFNA21;EGR2;STAT3;PIK3CG;IFNA1 |
Epstein-Barr virus infection | HLA-DRB4;HDAC1;FGR;POLR2B;POLR2I;HDAC4;IKBKG;TP53;EP300 |
Viral carcinogenesis | YWHAE;ACTN4;SRF;MAPK3;RHOA;HIST1H4M;IRF7;HDAC7A;SKP2 |
YWHAZ has several biochemical functions, for example, identical protein binding, poly(A) RNA binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by YWHAZ itself. We selected most functions YWHAZ had, and list some proteins which have the same functions with YWHAZ. You can find most of the proteins on our site.
Function | Related Protein |
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identical protein binding | GBP1;IFI203;RUVBL2;FXR2;BCL2;AXIN1;TRIM39;DNMT3A;ATF3 |
poly(A) RNA binding | ERH;HIST4H4;SKIV2L2;DDX50;CD3EAP;DDX28;ZFP598;DDX39B;FLNA |
protein binding | LAMTOR3;GLI1;KLHDC4;CCDC87;PKD2L1;FRMD6;SP1;PRDX3;CHERP |
protein domain specific binding | SHROOM2;TFDP1;STXBP1;NDE1;OSBP;NR0B2;SORBS2;MPP7;EZR |
protein kinase binding | PXN;LAT;CCNL1A;CD36;PLK1S1;CDC25A;E2F1;PTPN2;FER |
transcription factor binding | TNFRSF10A;APBB2;KAT2A;TRP53;TCF7L2;TFAP2A;PPID;GTF2A2;PIK3R1 |
ubiquitin protein ligase binding | CDC34;NGFR;PRDX6;UBE2B;SMAD5;UBE2G1;RNF31;KDM4A;ZFP746 |
YWHAZ has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with YWHAZ here. Most of them are supplied by our site. Hope this information will be useful for your research of YWHAZ.
RAF1; TSC2
- Q&As
- Reviews
Q&As (5)
Ask a questionYWHAZ is involved in cardiovascular diseases by influencing processes like vascular smooth muscle cell proliferation and apoptosis.
Yes, elevated levels of YWHAZ protein have been detected in certain cancers, making it a potential biomarker for cancer diagnosis.
Preliminary studies suggest that YWHAZ levels may be altered in cardiovascular diseases, making it a candidate biomarker for further investigation.
Research suggests that targeting YWHAZ protein may be a viable strategy for developing anticancer therapies.
Investigational studies are exploring the modulation of YWHAZ as a potential therapeutic approach for neurodegenerative disorders.
Customer Reviews (3)
Write a reviewI greatly appreciate their commitment to ensuring my research is a success.
The YWHAZ Protein offers a wide range of applications, making it highly versatile for various experimental settings.
With the YWHAZ Protein, I have the confidence to generate critical insights and drive significant advancements in my field.
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