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YWHAZ

  • Official Full Name

    tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide

  • Overview

    14-3-3 proteins are highly conserved proteins which play a role in both signal transduction and progression through the cell cycle by binding to and regulating several different proteins. 14-3-3 proteins activate tyrosine and tryptophan hydroxylases and protein kinase C. They mediate signal transduction by binding to phosphoserine-containing proteins. There are at least 7 mammalian isoforms: alpha, beta, gamma, delta, epsilon, zeta, and eta. An eighth subtype, termed theta has been found in rat brain. The 14-3-3 proteins exists in vitro and in vivo as either homo- or heterodimers which interact via their N-terminal domains and are subject to phosphorylation by protein kinase C. 14-3-3 proteins are localized in the cytoplasm of neurons in the cerebral cortex and are axonally transported to the nerve terminals. They may be present at lower levels in various other eukaryotic tissues. Northern blot analysis has shown expression of the eta chain in cultured cell lines derived from various tumors.
  • Synonyms

    YWHAZ; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide; tyrosine 3 monooxygenase/tryptophan 5 monooxygenase activation protein, delta polypeptide , YWHAD; 14-3-3 protein zeta/delta; 14 3 3 delta; 14 3 3 zeta; KCIP;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Yeast
  • C
  • Myc
  • DDK
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • SUMO
  • N/A
  • N
  • T7|His
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human YWHAZ-104H Recombinant Human Tyrosine 3-monooxygenase/ Tryptophan 5-monooxygenase Activation Protein, Zeta Polypeptide, His-tagged E.coli His
Human YWHAZ-4901H Recombinant Human Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein, Zeta Polypeptide E.coli N/A
Human YWHAZ-3776H Recombinant Human YWHAZ, GST-tagged E.coli GST 1-245aa
Human YWHAZ-831H Recombinant Human YWHAZ Protein, His-tagged E.coli His 2 - 245
Human YWHAZ-4900H Recombinant Human Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein, Zeta Polypeptide, GST-tagged E.coli GST
Human YWHAZ-203H Recombinant Human YWHAZ protein, T7/His-tagged E.coli T7/His
Human YWHAZ-153H Recombinant Human YWHAG Protein, His-tagged Insect Cell His
Human YWHAZ-229HCL Recombinant Human YWHAZ 293 Cell Lysate HEK293 N/A
Human YWHAZ-5831H Recombinant Human YWHAZ protein, His-tagged Yeast His 1-245 aa
Human YWHAZ-843H Recombinant Human YWHAZ Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human YWHAZ-226H Recombinant Human YWHAZ Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
Human YWHAZ-2861H Recombinant Human YWHAZ Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human YWHAZ-2381H Recombinant Human YWHAZ Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human YWHAZ-2799H Recombinant Human YWHAZ Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human YWHAZ-3779H Recombinant Human YWHAZ protein, His-GST-tagged E.coli His/GST 133-212aa
Human YWHAZ-467HFL Recombinant Full Length Human YWHAZ Protein, C-Flag-tagged Mammalian cells Flag
Human YWHAZ-2381H-B Recombinant Human YWHAZ Protein Pre-coupled Magnetic Beads HEK293
Human YWHAZ-6580H Recombinant Human YWHAZ Protein (Met1-Asn245), N-His tagged E.coli N-His Met1-Asn245
Mouse Ywhaz-152M Recombinant Mouse Ywhaz Protein, His-tagged Insect Cell His
Mouse YWHAZ-18687M Recombinant Mouse YWHAZ Protein Mammalian Cell His
Mouse YWHAZ-10271M Recombinant Mouse YWHAZ Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Ywhaz-3780M Recombinant Mouse Ywhaz protein, His-SUMO-tagged E.coli His-SUMO 1-245aa
Mouse Ywhaz-7044M Recombinant Mouse Ywhaz Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse YWHAZ-10271M-B Recombinant Mouse YWHAZ Protein Pre-coupled Magnetic Beads HEK293
Rat YWHAZ-6642R Recombinant Rat YWHAZ Protein Mammalian Cell His
Rat YWHAZ-6298R Recombinant Rat YWHAZ Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat YWHAZ-6298R-B Recombinant Rat YWHAZ Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque YWHAZ-5249R Recombinant Rhesus monkey YWHAZ Protein, His-tagged Mammalian Cell His
Rhesus Macaque YWHAZ-5062R Recombinant Rhesus Macaque YWHAZ Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque YWHAZ-5062R-B Recombinant Rhesus Macaque YWHAZ Protein Pre-coupled Magnetic Beads HEK293
Zebrafish YWHAZ-12027Z Recombinant Zebrafish YWHAZ Mammalian Cell His
Chicken YWHAZ-2997C Recombinant Chicken YWHAZ Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • YWHAZ Related Articles
  • YWHAZ Related Research Area

YWHAZ involved in several pathways and played different roles in them. We selected most pathways YWHAZ participated on our site, such as Cell cycle, Oocyte meiosis, PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with YWHAZ were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cell cycleCDC25A;SMARCA5;UIMC1;SMC1AL;CEP164;CLASP1;SKP1;RAD17;NCAPD3
Oocyte meiosisRPS6KA3A;CDC25C;PKMYT1;CALM3;MOS;RPS6KA6;CDK1;PRKACB;YWHAQA
PIK-Akt signaling pathwayMAP2K1;IBSP;PCK1;FGF11;BCL2L1;HRAS;MTCP1;FGF7;EIF4E2
Hippo signaling pathwayWNT10B;SMAD3;FZD6;STK3;FZD1;FZD2;SNAI2;APC2;WNT8B
Pathogenic Escherichia coli infectionTUBB1;WASL;NCL;ROCK1;TUBB6;ARHGEF2;ITGB1;TUBA1A;TUBA3D
Hepatitis BIRF3;IFN-a;IFNA8;TLR2;IFNA21;EGR2;STAT3;PIK3CG;IFNA1
Epstein-Barr virus infectionHLA-DRB4;HDAC1;FGR;POLR2B;POLR2I;HDAC4;IKBKG;TP53;EP300
Viral carcinogenesisYWHAE;ACTN4;SRF;MAPK3;RHOA;HIST1H4M;IRF7;HDAC7A;SKP2

YWHAZ has several biochemical functions, for example, identical protein binding, poly(A) RNA binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by YWHAZ itself. We selected most functions YWHAZ had, and list some proteins which have the same functions with YWHAZ. You can find most of the proteins on our site.

Function Related Protein
identical protein bindingGBP1;IFI203;RUVBL2;FXR2;BCL2;AXIN1;TRIM39;DNMT3A;ATF3
poly(A) RNA bindingERH;HIST4H4;SKIV2L2;DDX50;CD3EAP;DDX28;ZFP598;DDX39B;FLNA
protein bindingLAMTOR3;GLI1;KLHDC4;CCDC87;PKD2L1;FRMD6;SP1;PRDX3;CHERP
protein domain specific bindingSHROOM2;TFDP1;STXBP1;NDE1;OSBP;NR0B2;SORBS2;MPP7;EZR
protein kinase bindingPXN;LAT;CCNL1A;CD36;PLK1S1;CDC25A;E2F1;PTPN2;FER
transcription factor bindingTNFRSF10A;APBB2;KAT2A;TRP53;TCF7L2;TFAP2A;PPID;GTF2A2;PIK3R1
ubiquitin protein ligase bindingCDC34;NGFR;PRDX6;UBE2B;SMAD5;UBE2G1;RNF31;KDM4A;ZFP746

YWHAZ has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with YWHAZ here. Most of them are supplied by our site. Hope this information will be useful for your research of YWHAZ.

RAF1; TSC2

van Rijn, SJ; Riemers, FM; et al. Expression Stability of Reference Genes for Quantitative RT-PCR of Healthy and Diseased Pituitary Tissue Samples Varies Between Humans, Mice, and Dogs. MOLECULAR NEUROBIOLOGY 49:893-899(2014).
Weber, R; Bertoni, APS; et al. Validation of Reference Genes for Normalization Gene Expression in Reverse Transcription Quantitative PCR in Human Normal Thyroid and Goiter Tissue. BIOMED RESEARCH INTERNATIONAL :-(2014).
  • Q&As
  • Reviews

Q&As (5)

Ask a question
How does YWHAZ contribute to cardiovascular diseases? 09/03/2021

YWHAZ is involved in cardiovascular diseases by influencing processes like vascular smooth muscle cell proliferation and apoptosis.

Are there diagnostic applications of YWHAZ in cancer detection? 04/11/2021

Yes, elevated levels of YWHAZ protein have been detected in certain cancers, making it a potential biomarker for cancer diagnosis.

Is YWHAZ a potential biomarker for cardiovascular diseases? 01/27/2018

Preliminary studies suggest that YWHAZ levels may be altered in cardiovascular diseases, making it a candidate biomarker for further investigation.

Can YWHAZ protein be targeted for cancer treatment? 03/27/2016

Research suggests that targeting YWHAZ protein may be a viable strategy for developing anticancer therapies.

Are there potential therapeutic interventions targeting YWHAZ in neurodegenerative disorders? 03/18/2016

Investigational studies are exploring the modulation of YWHAZ as a potential therapeutic approach for neurodegenerative disorders.

Customer Reviews (3)

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Reviews
10/17/2022

    I greatly appreciate their commitment to ensuring my research is a success.

    01/01/2022

      The YWHAZ Protein offers a wide range of applications, making it highly versatile for various experimental settings.

      11/16/2020

        With the YWHAZ Protein, I have the confidence to generate critical insights and drive significant advancements in my field.

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