ywhaz
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  • Official Full Name
  • tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
  • Background
  • 14-3-3 proteins are highly conserved proteins which play a role in both signal transduction and progression through the cell cycle by binding to and regulating several different proteins. 14-3-3 proteins activate tyrosine and tryptophan hydroxylases and protein kinase C. They mediate signal transduction by binding to phosphoserine-containing proteins. There are at least 7 mammalian isoforms: alpha, beta, gamma, delta, epsilon, zeta, and eta. An eighth subtype, termed theta has been found in rat brain. The 14-3-3 proteins exists in vitro and in vivo as either homo- or heterodimers which interact via their N-terminal domains and are subject to phosphorylation by protein kinase C. 14-3-3 proteins are localized in the cytoplasm of neurons in the cerebral cortex and are axonally transported to the nerve terminals. They may be present at lower levels in various other eukaryotic tissues. Northern blot analysis has shown expression of the eta chain in cultured cell lines derived from various tumors.
  • Synonyms
  • YWHAZ; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide; tyrosine 3 monooxygenase/tryptophan 5 monooxygenase activation protein, delta polypeptide , YWHAD; 14-3-3 protein zeta/delta; 14 3 3 delta; 14 3 3 zeta; KCIP
Cat.#:YWHAZ-153HTag:His
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human YWHAG Protein, His-tagged
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Cat.#:YWHAZ-203HTag:T7/His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human YWHAZ protein, T7/His-tagged
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Cat.#:YWHAZ-3776HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human YWHAZ, GST-tagged
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Cat.#:YWHAZ-831HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human YWHAZ Protein, His-tagged
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Cat.#:Ywhaz-152MTag:His
Source (Host):Insect cellsSpecies:Mouse
Product nameRecombinant Mouse Ywhaz Protein, His-tagged
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Cat.#:YWHAZ-18687MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse YWHAZ Protein
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Cat.#:YWHAZ-6642RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat YWHAZ Protein
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Cat.#:YWHAZ-5249RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey YWHAZ Protein, His-tagged
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Cat.#:YWHAZ-2997CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken YWHAZ
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Cat.#:YWHAZ-12027ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish YWHAZ
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Cat.#:YWHAZ-229HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human YWHAZ 293 Cell Lysate
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Involved Pathway

YWHAZ involved in several pathways and played different roles in them. We selected most pathways YWHAZ participated on our site, such as Cell cycle, Oocyte meiosis, PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with YWHAZ were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cell cycle
AKAP9; PKMYT1; BUB1; KIF2C; NSL1; MCM6L; H3F3B.1; OIP5; ANKLE2; POLD3
Oocyte meiosis
CCNE1; YWHABL; SGOL1; PPP1CB; PPP3R1B; SPDYB; CALM3A; RPS6KAL; CALM3; IGF1RA
PIK-Akt signaling pathway
IL2RB; FGF8; MAP2K2; HRAS; NRAS; FGF3; GNGT1; PPP2R3A; PDGFA; TCL1A
Hippo signaling pathway
TEAD1; LATS1; ACTG1; PPP2R2C; WNT16; AJUBA; FZD6; YWHAH; YWHAZ; BMP5
Pathogenic Escherichia coli infection
CLDN1; ARHGEF2; TUBA1A; TUBB6; NCK2; LY96; ROCK1; CD14; ABL1; TLR5
Hepatitis B
NFATC4; PTEN; AKT2; PIK3CG; MAPK9; PIK3R1; HSPG2; TLR4; TLR2; STAT6
Epstein-Barr virus infection
RAN; TRP53; TRAF3; NFKBIB; VIM; HSPA1A; IL10RB; YWHAE; TBP; CCNA1
Viral carcinogenesis
HIST2H4; EP300; HIST1H2BM; ACTN4; VDAC3; IKBKG; CCNA1; ACTN3; GSN; LTBR

Protein Function

YWHAZ has several biochemical functions, for example, identical protein binding, poly(A) RNA binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by YWHAZ itself. We selected most functions YWHAZ had, and list some proteins which have the same functions with YWHAZ. You can find most of the proteins on our site.
Function
Related Protein
Function identical protein binding
Related Protein GDF5; NDC80; TPCN1; IGF2R; KCNJ2; SCUBE1; IK; C10orf88; BNIP3L; IRF3
Function poly(A) RNA binding
Related Protein RPS4Y1; MRPS14; SNRPB; SF3A2; PPIB; RPL3; WBP11; ZAK; RPP30; EIF3A
Function protein binding
Related Protein XIRP2; HIST1H3A; RNF40; TNS1; TREML2; PSMA4; CCNF; ZNHIT3; XRCC3; CYHR1
Function protein domain specific binding
Related Protein PHRF1; NR0B2; GUSB; LIN7B; CHMP1B; PICK1; ERCC1; YWHAQA; PLXND1; BHLHE40
Function protein kinase binding
Related Protein FOXM1; PKD1; GSTP2; CCND2; CACNB4; CASP9; CALM3; VDAC1; ZC3HC1; PXN
Function transcription factor binding
Related Protein HMGA2; HDAC7; NCOA2; RELA; FOXC1; DIP2BA; MDFI; SOX17; TWIST1; MECP2
Function ubiquitin protein ligase binding
Related Protein OTUB1; CUL4B; SLC25A5; NGFR; ATXN3; USP25; TRAF5; HSPD1; FBXW7; TRP53

Interacting Protein

YWHAZ has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with YWHAZ here. Most of them are supplied by our site. Hope this information will be useful for your research of YWHAZ.
RAF1; TSC2

YWHAZ Related Articles

van Rijn, SJ; Riemers, FM; et al. Expression Stability of Reference Genes for Quantitative RT-PCR of Healthy and Diseased Pituitary Tissue Samples Varies Between Humans, Mice, and Dogs. MOLECULAR NEUROBIOLOGY 49:893-899(2014).
Weber, R; Bertoni, APS; et al. Validation of Reference Genes for Normalization Gene Expression in Reverse Transcription Quantitative PCR in Human Normal Thyroid and Goiter Tissue. BIOMED RESEARCH INTERNATIONAL :-(2014).