Recombinant Full Length Human A2ML1 Protein, GST-tagged

• Cat.No.: A2ML1-742HF
• Product Overview: Human A2ML1 full-length ORF ( AAH93840.1, 1 a.a. - 158 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: This gene encodes a member of the alpha-macroglobulin superfamily. The encoded protein is thought to be an N-glycosylated monomeric protein that acts as an inhibitor of several proteases. It has been shown to form covalent interactions with proteases, and has been reported as the p170 antigen recognized by autoantibodies in the autoimmune disease paraneoplastic pemphigus (PNP; PMID:20805888). Mutations in these gene have also been associated with some cases of Noonan syndrome (NS; PMID:24939586) as well as some cases of otitis media (PMID:26121085). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015]
• Source: In Vitro Cell Free System
• Species: Human
• Tag: GST
• Form: 50 mM Tris-HCl, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
• Molecular Mass: 44.1 kDa
• Protein length: 158 amino acids
• AA Sequence: MYTLEASGQG CVYVQTVLRY NILPPTNMKT FSLSVEIGKA RCEQPTSPRS LTLTIHTSYV GSRSSSNMAI VEVKMLSGFS PMEGTNQLLL QQPLVKKVEF GTDTLNIYLD ELIKNTQTYT FTISQSVLVT NLKPATIKVY DYYLPDEQAT IQYSDPCE
• Applications: Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.

Gene Information

• Gene Name: A2ML1 alpha-2-macroglobulin-like 1 [ Homo sapiens ]
• Official Symbol: A2ML1
• Synonyms: A2ML1; alpha-2-macroglobulin-like 1; C3 and PZP like, alpha 2 macroglobulin domain containing 9 , CPAMD9; alpha-2-macroglobulin-like protein 1; FLJ25179; C3 and PZP-like, alpha-2-macroglobulin domain containing 9; CPAMD9; FLJ16045; FLJ39129; FLJ41597; FLJ41598; FLJ41607; DKFZp686C1729; DKFZp686D2011; DKFZp686G1812; DKFZp686L1821; DKFZp686O1010
• Gene ID: 144568
• mRNA Refseq: NM_144670
• Protein Refseq: NP_653271
• MIM: 610627
• UniProt ID: A8K2U0