Recombinant Human A2ML1 cell lysate

• Cat.No.: A2ML1-2105HCL

Specification

• Description: The alpha-macroglobulin (AM) superfamily of proteins contains both complement components and protease inhibitors, including A2M (MIM 103950) and A2ML1. AM proteins display a unique trap mechanism of inhibition, by which the AM inhibitor undergoes a major conformational change upon its cleavage by a protease, thus trapping the protease and blocking it from subsequent substrate binding (Galliano et al., 2006 [PubMed 16298998]).
• Species: Human
• Size: 100 ul
• Storage Buffer: 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
• Applications: Western Blot

Gene Information

• Gene Name: A2ML1 alpha-2-macroglobulin-like 1 [ Homo sapiens ]
• Official Symbol: A2ML1
• Synonyms: A2ML1; alpha-2-macroglobulin-like 1; C3 and PZP like, alpha 2 macroglobulin domain containing 9 , CPAMD9; alpha-2-macroglobulin-like protein 1; FLJ25179; C3 and PZP-like, alpha-2-macroglobulin domain containing 9; CPAMD9; FLJ16045; FLJ39129; FLJ41597; FLJ41598; FLJ41607; DKFZp686C1729; DKFZp686D2011; DKFZp686G1812; DKFZp686L1821; DKFZp686O1010
• Gene ID: 144568
• mRNA Refseq: NM_144670
• Protein Refseq: NP_653271
• MIM: 610627
• UniProt ID: A8K2U0
• Chromosome Location: 12p13
• Function: peptidase inhibitor activity; serine-type endopeptidase inhibitor activity