Recombinant Human A2ML1 Protein, Myc/DDK-tagged, C13 and N15-labeled

Cat.No. : A2ML1-1627H
Product Overview : A2ML1 MS Standard C13 and N15-labeled recombinant protein (NP_653271) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.
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Description : This gene encodes a member of the alpha-macroglobulin superfamily. The encoded protein is thought to be an N-glycosylated monomeric protein that acts as an inhibitor of several proteases. It has been shown to form covalent interactions with proteases, and has been reported as the p170 antigen recognized by autoantibodies in the autoimmune disease paraneoplastic pemphigus (PNP; PMID:20805888). Mutations in these gene have also been associated with some cases of Noonan syndrome (NS; PMID:24939586) as well as some cases of otitis media (PMID:26121085). Alternative splicing results in multiple transcript variants encoding different isoforms.
Source : HEK293
Species : Human
Tag : Myc/DDK
Molecular Mass : 161 kDa
AA Sequence : MWAQLLLGMLALSPAIAEELPNYLV TLPARLNFPSVQKVCLDLSPGYSDV KFTVTLETKDKTQKLLEYSGLKKRH LHCISFLVPPPAGGTEEVATIRVSG VGNNISFEEKKKVLIQRQGNGTFVQ TDKPLYTPGQQVYFRIVTMDSNFVP VNDKYSMVELQDPNSNRIAQWLEVV PEQGIVDLSFQLAPEAMLGTYTVAV AEGKTFGTFSVEEYVLPKFKVEVVE PKELSTVQESFLVKICCRYTYGKPM LGAVQVSVCQKANTYWYREVEREQL PDKCRNLSGQTDKTGCFSAPVDMAT FDLIGYAYSHQINIVATVVEEGTGV EANATQNIYISPQMGSMTFEDTSNF YHPNFPFSGKIRVRGHDDSFLKNHL VFLVIYGTNGTFNQTLVTDNNGLAP FTLETSGWNGTDVSLEGKFQMEDLV YNPEQVPRYYQNAYLHLRPFYSTTR SFLGIHRLNGPLKCGQPQEVLVDYY IDPADASPDQEISFSYYLIGKGSLV MEGQKHLNSKKKGLKASFSLSLTFT SRLAPDPSLVIYAIFPSGGVVADKI QFSVEMCFDNQVSLGFSPSQQLPGA EVELQLQAAPGSLCALRAVDESVLL LRPDRELSNRSVYGMFPFWYGHYPY QVAEYDQCPVSGPWDFPQPLIDPMP QGHSSQRSIIWRPSFSEGTDLFSFF RDVGLKILSNAKIKKPVDCSHRSPE YSTAMGAGGGHPEAFESSTPLHQAE DSQVRQYFPETWLWDLFPIGNSGKE AVHVTVPDAITEWKAMSFCTSQSRG FGLSPTVGLTAFKPFFVDLTLPYSV VRGESFRLTATIFNYLKDCIRVQTD LAKSHEYQLESWADSQTSSCLCADE AKTHHWNITAVKLGHINFTISTKIL DSNEPCGGQKGFVPQKGRSDTLIKP VLVKPEGVLVEKTHSSLLCPKGKVA SESVSLELPVDIVPDSTKAYVTVLG DIMGTALQNLDGLVQMPSGCGEQNM VLFAPIIYVLQYLEKAGLLTEEIRS RAVGFLEIGYQKELMYKHSNGSYSA FGERDGNGNTWLTAFVTKCFGQAQK FIFIDPKNIQDALKWMAGNQLPSGC YANVGNLLHTAMKGGVDDEVSLTAY VTAALLEMGKDVDDPMVSQGLRCLK NSATSTTNLYTQALLAYIFSLAGEM DIRNILLKQLDQQAIISGESIYWSQ KPTPSSNASPWSEPAAVDVELTAYA LLAQLTKPSLTQKEIAKATSIVAWL AKQRNAYGGFSSTQDTVVALQALAK YATTAYMPSEEINLVVKSTENFQRT FNIQSVNRLVFQQDTLPNVPGMYTL EASGQGCVYVQTVLRYNILPPTNMK TFSLSVEIGKARCEQPTSPRSLTLT IHTSYVGSRSSSNMAIVEVKMLSGF SPMEGTNQLLLQQPLVKKVEFGTDT LNIYLDELIKNTQTYTFTISQSVLV TNLKPATIKVYDYYLPDEQATIQYS DPCETRTRPLEQKLISEEDLAANDI LDYKDDDDKV
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 3 months from receipt of products under proper storage and handling conditions.
Storage : Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
Concentration : 50 μg/mL as determined by BCA
Storage Buffer : 100 mM glycine, 25 mM Tris-HCl, pH 7.3.
FACS:
Gene Name : A2ML1 alpha-2-macroglobulin-like 1 [ Homo sapiens (human) ]
Official Symbol : A2ML1
Synonyms : A2ML1; alpha-2-macroglobulin-like 1; C3 and PZP like, alpha 2 macroglobulin domain containing 9, CPAMD9; alpha-2-macroglobulin-like protein 1; FLJ25179; C3 and PZP-like, alpha-2-macroglobulin domain containing 9; CPAMD9; FLJ16045; FLJ39129; FLJ41597; FLJ41598; FLJ41607; DKFZp686C1729; DKFZp686D2011; DKFZp686G1812; DKFZp686L1821; DKFZp686O1010;
Gene ID : 144568
mRNA Refseq : NM_144670
Protein Refseq : NP_653271
MIM : 610627
UniProt ID : A8K2U0

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