ABCB1
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Official Full Name
ATP-bindingcassette, sub-family B (MDR/TAP), member 1
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Overview
P-glycoprotein (permeability glycoprotein, abbreviated as P-gp or Pgp) is a well-characterized ABC-transporter of the MDR/TAP subfamily. P-gp is also called ABCB1, ATP-binding cassette sub-family B member 1, MDR1, and PGY1. P-glycoprotein has also recently been designated CD243 (cluster of differentiation 243). In humans, P-glycoprotein is encoded by the ABCB1 gene. Pgp is extensively distributed and expressed in the intestinal epithelium, hepatocytes, renal proximal tubular cells, adrenal gland and capillary endothelial cells comprising the blood-brain and blood-testis barrier. Genetic variations in ABCB1 are associated with susceptibility to inflammatory bowel disease type 13 (IBD13) Inflammatory bowel disease is characterized by a chronic relapsing intestinal inflammation. -
Synonyms
ABC20; ABCB1; ATP binding cassette sub family B MDR/TAP member 1; ATP-binding cassette sub-family B member 1; CD243; CD243 antigen; CLCS; GP170;; MDR1; Multidrug resistance protein 1; P glycoprotein 1; P gp; P-glycoprotein 1; PGY1 antibody; P-Glycoprotein; ABCB1; ATP-bindingcassette, sub-family B (MDR/TAP), member 1;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Cynomolgus Monkey
- Human
- Mouse
- Rhesus Macaque
- E. coli
- E.coli
- HEK293
- Human Cells
- Insect Cell
- Mammalian Cell
- Wheat Germ
- C
- His
- DDK
- GST
- His (Fc)
- Avi
- His|GST
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- ABCB1 Related Articles
- ABCB1 Related Research Area
ABCB1 involved in several pathways and played different roles in them. We selected most pathways ABCB1 participated on our site, such as ABC transporters, Bile secretion, MicroRNAs in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with ABCB1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| ABC transporters | ABCG1;ABCA6;ABCG2A;ABCG3;Abca2;ABCC4;ABCB10;ABCG5;ABCA1B |
| Bile secretion | SLCO1A4;Slc4a2;SLC5A1;SLC10A1;SLC10A2;OSTA;SLCO1A5;SLC9A3;SLC9A1 |
| MicroRNAs in cancer | TTC6;BCL2L2;VEGFA;SOCS1;PTEN;BAK1;CDC25C;MCL1;APC2 |
ABCB1 has several biochemical functions, for example, ATP binding, ATPase activity, coupled to transmembrane movement of substances, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ABCB1 itself. We selected most functions ABCB1 had, and list some proteins which have the same functions with ABCB1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | PAPD4;PAPSS2B;ACSL5;MYH10;ATP11C;PRKD3;SCYL3;TOP2B;FARS2 |
| ATPase activity, coupled to transmembrane movement of substances | ABCG3;ABCD3A;ABCG2;ABCA9;ABCG5;ABCC9;Abca2;ABCB6;ABCB5 |
| protein binding | ASUN;KDR;MFAP4;PRKD1;GSTK1;PIN4;IP6K2;ZNF559-ZNF177;CRYAB |
| transporter activity | RBP5;RBP4L;FXYD2;SLC37A4;HIAT1A;SYPL2B;CPNE3;PTGDSB;SLC51B |
| xenobiotic-transporting ATPase activity | ABCB4;ABCB1A;ABCB1;ABCG2;Abcb1b |
ABCB1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ABCB1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ABCB1.
RNF2; LAPTM4B; PHB2; CD4; MAPKAP1; BCCIP; MYC; CAV1; LAPTM4B
- Q&As
- Reviews
Q&As (11)
Ask a questionMany inhibitors can reverse ABCB1-mediated docetaxel resistance, different agents for different tumor, such as erastin in ovarian cancer.
In humans, ABCB1 genotyping in the treatment of depression rests on the assumption that genetic variations in ABCB1 explain individual differences in antidepressant response via their effects on P-gp expression at the blood-brain barrier.
Genetic variation in ABCB1 is associated with the pathogenesis of several dermatoses, including psoriasis, atopic dermatitis, melanoma, bullous pemphigoid, Behçet disease, and lichen planus.
Many agents could interact with ABCB1 including topical steroids, methotrexate, cyclosporine, azathioprine, antihistamines, antifungal agents, colchicine, tacrolimus, ivermectin, tetracycline, retinoid acids, and biologic agents.
There are large differences in the expression of P-glycoprotein in human liver, but this difference is not related to the C(3435)T and G(2677)T(A) polymorphisms in the ABCB1 gene.
Not only a nonpermissive chromatin structure (methylated) but either the absence of important transcriptional activators or the presence of repressors and co-repressors and the proteins like HDACs recruited by co-repressors can also inhibit gene transcription. The correlation between methylation and gene silencing for several genes are evidenced by researchers but many times there is absence of correlation observed for some genes too.
The convention is what is upstream of the downstream promoter is exon1a, and downstream of it, exon1b.
The human intestinal cell line Caco-2 has been reported to express,and cell lines such as MDCK and LLC-PK1 which have been transfected or transduced to overexpress ABCB1.
AMP-PNP, AMP-PCP, or ATP-gamma-S, but the required concentration will undoubtedly be quite high (mM).
Whether it is an artifact from nonspecific binding or a natural fragment of the target protein, the precise evaluation can be done by applying in-gel digestion followed by MS-based proteomic identification.
A related new study paper through recombinant mouse proteins has been published in the open access journal BioDiscovery, studying the second generation tyrosine kinase inhibitor (TKI) - dasatinib (DAS) and ATP binding (ABC) transport proteins ABCB1 and ABCG2 mechanism to assess whether these drug transporters may impair the therapeutic effect.
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