Recombinant Human ABCB1 Protein, DDK-tagged

Species :	Human
Source :	Insect Cells
Tag :	Flag
Protein Length :	995-1280 aa
Description :	The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. [provided by RefSeq, Jul 2008].
Form :	50 mM Tris.HCl, pH 8.0, 100 mM glycine, 10 % glycerol. Store at -80 centigrade. Avoid repeated freeze-thaw cycles. Stable for at least 3 months from receipt of products under proper storage and handling conditions.
Molecular Mass :	31.3 kDa
Purity :	> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration :	>50 ug/mL as determined by microplate BCA method

Gene Name	ATP binding cassette subfamily B member 1 [ Homo sapiens ]
Official Symbol	ABCB1
Synonyms	ABC20; CD243; CLCS; GP170; MDR1; P-GP; PGY1
Gene ID	5243
mRNA Refseq	NM_000927.4
Protein Refseq	NP_000918.2
MIM	171050
UniProt ID	P08183