Recombinant Human ABCB1 Protein, DDK-tagged

• Cat.No.: ABCB1-235H
• Product Overview: Recombinant human ABCB1 protein, fused to DDK-tag at C-terminal, was expressed in E.coli.

Specification

• Species: Human
• Source: Insect Cells
• Tag: Flag
• Protein Length: 995-1280 aa
• Description: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. [provided by RefSeq, Jul 2008].
• Form: 50 mM Tris.HCl, pH 8.0, 100 mM glycine, 10 % glycerol. Store at -80 centigrade. Avoid repeated freeze-thaw cycles. Stable for at least 3 months from receipt of products under proper storage and handling conditions.
• Molecular Mass: 31.3 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: ATP binding cassette subfamily B member 1 [ Homo sapiens ]
• Official Symbol: ABCB1
• Synonyms: ABC20; CD243; CLCS; GP170; MDR1; P-GP; PGY1
• Gene ID: 5243
• mRNA Refseq: NM_000927.4
• Protein Refseq: NP_000918.2
• MIM: 171050
• UniProt ID: P08183