Recombinant Human TMPRSS3 Protein, His tagged

• Cat.No.: ABCB1-10H
• Product Overview: Purified recombinant protein of Human ATP-binding cassette, sub-family B (MDR/TAP), member 1 (ABCB1), Gln347-Tyr710, with N-terminal His tag, expressed in E.coli.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 347-710 aa
• Description: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. Mutations in this gene are associated with colchicine resistance and Inflammatory bowel disease 13. Alternative splicing and the use of alternative promoters results in multiple transcript variants.
• Molecular Mass: 40.4 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Note: For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Storage Buffer: 50 mM Tris-HCl, pH 8.0, 8 M urea
• Concentration: > 0.05 μg/μL as determined by microplate BCA method
• Shipping: Dry Ice

Gene Information

• Gene Name 2: ABCB1 ATP binding cassette subfamily B member 1 [ Homo sapiens (human) ]
• Official Symbol 2: ABCB1
• Synonyms 2: ABCB1; ATP binding cassette subfamily B member 1; CLCS; MDR1; P-GP; PGY1; ABC20; CD243; ENPAT; GP170; p-170; ATP-dependent translocase ABCB1; ATP-binding cassette, sub-family B (MDR/TAP), member 1; P-glycoprotein 1; colchicin sensitivity; doxorubicin resistance; multidrug resistance protein 1; phospholipid transporter ABCB1; EC 7.6.2.1; EC 7.6.2.2
• Gene ID 2: 5243
• mRNA Refseq 2: NM_000927
• Protein Refseq 2: NP_000918
• MIM 2: 171050
• UniProt ID 2: P08183