ACTC1
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Official Full Name
Actin, Alpha, Cardiac Muscle 1
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Overview
Actins are highly conserved proteins that are involved in various types of cell motility. Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to four others. The protein encoded by this gene belongs to the actin family which is comprised of three main groups of actin isoforms, alpha, beta, and gamma. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. -
Synonyms
ACTC1; actin, alpha, cardiac muscle 1; ACTC; ASD5; CMD1R; CMH11; LVNC4; OTTHUMP00000160081; alpha-cardiac actin;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Native Proteins
- Bovine
- Chicken
- Human
- Mouse
- Rat
- Bovine cardiac
- Bovine cardiac muscle
- Bovine Heart
- E. coli
- E.coli
- E.Coli or Yeast
- HEK293
- HEK293T
- Human Heart
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- His|T7
- Myc
- DDK
- MYC
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- ACTC1 Related Articles
- ACTC1 Related Research Area
ACTC1 involved in several pathways and played different roles in them. We selected most pathways ACTC1 participated on our site, such as Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, Hypertrophic cardiomyopathy (HCM), which may be useful for your reference. Also, other proteins which involved in the same pathway with ACTC1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cardiac muscle contraction | TNNT2A;CACNA1SA;UQCRC2A;COX5AA;ATP1A3B;ATP1A2A;ATP1B3B;ATP1A1B;UQCRC1 |
| Adrenergic signaling in cardiomyocytes | ADRB3A;CALM2B;ATP1B2;NETO2;AKT3A;MAPK14B;TNNT2;CACNA1DA;AGTR2 |
| Hypertrophic cardiomyopathy (HCM) | SGCA;ITGB3;PRKAB2;ITGAV;CACNB1;CACNA2D1;ACTB;CACNA2D3;ITGA6 |
| Dilated cardiomyopathy | PRKACB;ITGA6;CACNG3;DES;ACTC1;TGFB2;CACNG1;LMNA;ITGA8 |
ACTC1 has several biochemical functions, for example, ATP binding, ATPase activity, myosin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ACTC1 itself. We selected most functions ACTC1 had, and list some proteins which have the same functions with ACTC1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | ATP2C1;HIPK1;TOR1L1;SMOK2B;ABCG3;PAK7;ABCB6A;NTRK3A;SWAP70 |
| ATPase activity | ABCA1B;ABCG4B;ABCB4;VPS4A;ASNA1;ERCC3;MLH3;EIF4A1A;HSPD1 |
| myosin binding | FXYD1;VAMP2;MYBPC3;CALD1B;RHOA;SLC6A4;USH2A;CALM;ARFGEF1 |
ACTC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACTC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ACTC1.
ESR1; GAPDH; C1QTNF9; MYBPC3; TNNI3K; TRIM63; BCL11A; ASH2L; MPC1; ere_dna; MYC; VCAM1; ARRB2; HTR7; MYH9
- Q&As
- Reviews
Q&As (20)
Ask a questionACTC1 mutations, such as the G247D mutation, have been linked to atrial-septal defect followed by late-onset dilated cardiomyopathy (DCM).
Knockdown of ACTC1 inhibits U87MG cell migration.
Significant expression quantitative trait loci (eQTL) associated with Actc1 expression have been identified in both heart and soleus (a skeletal muscle)
ACTC1 mutations have been implicated in atrial septal defect, dilated cardiomyopathy, hypertrophic cardiomyopathy, and left ventricular noncompaction.
ACTC1 encodes a highly conserved actin protein that binds to myosin in both cardiac and skeletal muscle, suggesting shared functions between the two muscle types.
Mutations in the ACTA1 gene, which encodes skeletal muscle α-actin, can cause lethal muscle diseases. However, transgenic over-expression of cardiac α-actin (ACTC1) has been shown to rescue the disease phenotype in ACTA1 mouse models.
The discovery of mutations in ACTC1 expands our knowledge of genetic disorders and identifies a new condition associated with ACTC1 mutations, highlighting the importance of this gene in muscle-related conditions.
Mutations in ACTC1 have been linked to atrial septal defect, dilated cardiomyopathy, hypertrophic cardiomyopathy, and left ventricular noncompaction.
The G247D ACTC1 mutation negatively regulates serum response (SRF)-signaling, which contributes to the development of late-onset DCM.
Transgenic over-expression of ACTC1 rescues the disease phenotype observed in ACTA1 mouse models, which are affected by lethal muscle diseases.
Studies have examined methylation, histone modification, and chromatin accessibility as marks of regulatory potential, with methylation around the Actc1 transcriptional start site showing a strain-dependent correlation with Actc1 expression in skeletal muscle.
The shared functions of ACTC1 in both cardiac and skeletal muscle indicate overlapping roles and potential implications for muscle function and disease processes.
Actc1 expression can vary up to 24-fold in skeletal muscle among different strains, as observed in the strains from The Collaborative Cross (CC) genetic resource.
ACTC1 has been identified as a potential marker to detect GBM migration in clinical cases.
The highly conserved nature of the ACTC1 actin protein suggests its fundamental importance in muscle function across species.
The shared functions of ACTC1 in cardiac and skeletal muscle indicate potential overlapping mechanisms in muscle-related diseases and may guide future research and therapeutic approaches targeting ACTC1-related conditions.
ACTC1 is the predominant striated α-actin isoform in the heart.
Methylation around the Actc1 transcriptional start site in early adult skeletal muscle negatively correlates with Actc1 expression in a strain-dependent manner, indicating a potential regulatory role.
Reduced ACTC1 expression may contribute to the onset of congenital heart disease (CHD) through the induction of cardiomyocyte apoptosis.
Actc1 expression can vary up to 24-fold in skeletal muscle, as observed in strains from The Collaborative Cross (CC) genetic resource.
Customer Reviews (5)
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