Recombinant Human ACTC1 protein, His & T7-tagged
Cat.No. : | ACTC1-6835H |
Product Overview : | Recombinant Human ACTC1 aa. (Asp156~Gly368 (Accession # P68032)) fused with N-terminal His & T7 tag was produced in E. coli cells. |
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Description : | Actins are highly conserved proteins that are involved in various types of cell motility. Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to four others. The protein encoded by this gene belongs to the actin family which is comprised of three main groups of actin isoforms, alpha, beta, and gamma. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. Defects in this gene have been associated with idiopathic dilated cardiomyopathy (IDC) and familial hypertrophic cardiomyopathy (FHC). |
Source : | E. coli |
Species : | Human |
Tag : | His & T7 |
Form : | Freeze-dried powder |
Molecular Mass : | Predicted Molecular Mass: 27.6kDa. |
Protein length : | Asp156~Gly368 (Accession # P68032) |
Endotoxin : | <1.0EU per 1ug (determined by the LAL method) |
Purity : | >95% |
Characteristic : | The isoelectric point is 5.7. |
Applications : | SDS-PAGE; WB; ELISA; IP. |
Stability : | The thermal stability is described by the loss rate of the target protein. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. (Referring from China Biological Products Standard, which was calculated by the Arrhenius equation.) The loss of this protein is less than 5% within the expiration date under appropriate storage condition. |
Storage : | Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months. |
Storage buffer : | Supplied as lyophilized form in PBS, pH7.4, containing 5% sucrose, 0.01% sarcosyl. |
Reconstitution : | Reconstitute in sterile PBS, pH7.2-pH7.4. |
Publication : |
An autoantibody profile detects Brugada syndrome and identifies abnormally expressed myocardial proteins (2020)
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Gene Name : | ACTC1 actin, alpha, cardiac muscle 1 [ Homo sapiens (human) ] |
Official Symbol : | ACTC1 |
Synonyms : | ACTC; ASD5; CMD1R; CMH11; LVNC4; actin, alpha cardiac muscle 1 |
Gene ID : | 70 |
mRNA Refseq : | NM_005159.4 |
Protein Refseq : | NP_005150.1 |
UniProt ID : | P68032 |
Products Types
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◆ Native Protein | ||
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◆ Lysates | ||
ACTC1-9065HCL | Recombinant Human ACTC1 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (20)
Ask a questionACTC1 mutations, such as the G247D mutation, have been linked to atrial-septal defect followed by late-onset dilated cardiomyopathy (DCM).
Knockdown of ACTC1 inhibits U87MG cell migration.
Significant expression quantitative trait loci (eQTL) associated with Actc1 expression have been identified in both heart and soleus (a skeletal muscle)
ACTC1 mutations have been implicated in atrial septal defect, dilated cardiomyopathy, hypertrophic cardiomyopathy, and left ventricular noncompaction.
ACTC1 encodes a highly conserved actin protein that binds to myosin in both cardiac and skeletal muscle, suggesting shared functions between the two muscle types.
Mutations in the ACTA1 gene, which encodes skeletal muscle α-actin, can cause lethal muscle diseases. However, transgenic over-expression of cardiac α-actin (ACTC1) has been shown to rescue the disease phenotype in ACTA1 mouse models.
The discovery of mutations in ACTC1 expands our knowledge of genetic disorders and identifies a new condition associated with ACTC1 mutations, highlighting the importance of this gene in muscle-related conditions.
Mutations in ACTC1 have been linked to atrial septal defect, dilated cardiomyopathy, hypertrophic cardiomyopathy, and left ventricular noncompaction.
The G247D ACTC1 mutation negatively regulates serum response (SRF)-signaling, which contributes to the development of late-onset DCM.
Transgenic over-expression of ACTC1 rescues the disease phenotype observed in ACTA1 mouse models, which are affected by lethal muscle diseases.
Studies have examined methylation, histone modification, and chromatin accessibility as marks of regulatory potential, with methylation around the Actc1 transcriptional start site showing a strain-dependent correlation with Actc1 expression in skeletal muscle.
The shared functions of ACTC1 in both cardiac and skeletal muscle indicate overlapping roles and potential implications for muscle function and disease processes.
Actc1 expression can vary up to 24-fold in skeletal muscle among different strains, as observed in the strains from The Collaborative Cross (CC) genetic resource.
ACTC1 has been identified as a potential marker to detect GBM migration in clinical cases.
The highly conserved nature of the ACTC1 actin protein suggests its fundamental importance in muscle function across species.
The shared functions of ACTC1 in cardiac and skeletal muscle indicate potential overlapping mechanisms in muscle-related diseases and may guide future research and therapeutic approaches targeting ACTC1-related conditions.
ACTC1 is the predominant striated α-actin isoform in the heart.
Methylation around the Actc1 transcriptional start site in early adult skeletal muscle negatively correlates with Actc1 expression in a strain-dependent manner, indicating a potential regulatory role.
Reduced ACTC1 expression may contribute to the onset of congenital heart disease (CHD) through the induction of cardiomyocyte apoptosis.
Actc1 expression can vary up to 24-fold in skeletal muscle, as observed in strains from The Collaborative Cross (CC) genetic resource.
Customer Reviews (5)
Write a reviewThe protein product delivers exceptional results, surpassing our expectations in terms of its effectiveness.
The protein product demonstrates exceptional purity, free from any interfering impurities.
The protein product maintains remarkable consistency across multiple batches, ensuring reproducibility in our experiments.
The customer support provided by the company is exceptional, promptly addressing any inquiries or concerns.
The protein product was delivered in a timely manner, and the packaging was secure, ensuring product integrity.
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