Native Human Actin, Alpha, Cardiac Muscle 1

• Cat.No.: ACTC1-5294H
• Product Overview: Native human ACTC1 wasexpressed in ACTC1 Human Heart.

Specification

• Cat. No.: ACTC1-5294H
• Description: Theactin family is comprised of 3 main groups of actin isoforms, alpha, beta,and gamma. The ACTC1 are found in muscle tissues and are a major constituentof the contractile apparatus. The beta and gamma actins coexist in most celltypes as components of the cytoskeleton. Defects in this gene have beenassociated with idiopathic dilated cardiomyopathy (IDC) and familialhypertrophic cardiomyopathy (FHC).
• Form: Lyophilized from asolution containing 20 mM Tris + 0.2 M NaCl + 1 mM ATP.
• Source: Human Heart
• Biological Activity: Sample testedpositive for Muscle Actin activity by Western blot.
• Concentration: 1 mg/ml
• Endotoxin Level: < 0.1 ng/µg ofprotein.
• Reconstitution: Reconstitute withneutral buffer or deionized water.
• Storage: Reconstitutedprotein is stable for 1 week at 2-4°C. For long term storage, aliquot and freezeat -20°C. Avoid repeated freeze-thaw cycles.
• Pathways: Cardiacmuscle contraction; Dilated cardiomyopathy; Hypertrophic cardiomyopathy(HCM); Myometrial Relaxation and Contraction Pathways; Striated MuscleContraction

Gene Information

• Gene Name: ACTC1 actin, alpha, cardiac muscle1 [ Homo sapiens ]
• Official Symbol: ACTC1
• Synonyms: ACTC1; actin, alpha, cardiacmuscle 1; ACTC; ASD5; CMD1R; CMH11; LVNC4; actin, alpha cardiac muscle 1;OTTHUMP00000160081; alpha-cardiac actin; Alpha-cardiac actin
• Gene ID: 70
• mRNA Refseq: NM_005159
• Protein Refseq: NP_005150
• MIM: 102540
• UniProt ID: P68032
• Chromosome Location: 15q11-q14
• Function: ATPbinding; ATPase activity; myosin binding; nucleotide binding