ACY1 Protein

September 27-30, 2022

Boston Convention and Exhibition Center

Booth #336

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ACY1

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ACY1

Official Full Name aminoacylase 1
Background This gene encodes a cytosolic, homodimeric, zinc-binding enzyme that catalyzes the hydrolysis of acylated L-amino acids to L-amino acids and an acyl group, and has been postulated to function in the catabolism and salvage of acylated amino acids. This gene is located on chromosome 3p21.1, a region reduced to homozygosity in small-cell lung cancer (SCLC), and its expression has been reported to be reduced or undetectable in SCLC cell lines and tumors. The amino acid sequence of human aminoacylase-1 is highly homologous to the porcine counterpart, and this enzyme is the first member of a new family of zinc-binding enzymes. Mutations in this gene cause aminoacylase-1 deficiency, a metabolic disorder characterized by central nervous system defects and increased urinary excretion of N-acetylated amino acids. Alternative splicing of this gene results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ABHD14A (abhydrolase domain containing 14A) gene, as represented in GeneID:100526760. A related pseudogene has been identified on chromosome 18.
Synonyms ACY1; aminoacylase 1; aminoacylase-1; acylase; N-acyl-L-amino-acid amidohydrolase; ACY-1; ACY1D
    • Species :
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Human Cell
    • Insect Cell
    • Mammalian Cell
    • Mammalian cells
    • Wheat Germ
    • Tag :
    • DDK
    • GST
    • His
    • MYC/DDK
    • Myc
    • N/A
    • T7
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human ACY1-165H Recombinant Human ACY1 protein, T7-tagged E.coli T7
    Human ACY1-242H Recombinant Human ACY1, His tagged Insect Cell His
    Human ACY1-262H Recombinant Human ACY1 Protein, GST-tagged Wheat Germ GST
    Human ACY1-26570TH Recombinant Human ACY1, His-tagged E.coli His
    Human ACY1-27198TH Recombinant Human ACY1, His-tagged E.coli His
    Human ACY1-27H Recombinant Human Aminoacylase 1, T7-tagged E.coli T7
    Human ACY1-327H Recombinant Human ACY1 Protein, DDK-tagged Insect Cell DDK
    Human ACY1-781H Recombinant Human Aminoacylase 1, His-tagged E.coli His
    Mouse Acy1-111M Recombinant Mouse Acy1, His-tagged E.coli His
    Mouse Acy1-1128M Recombinant Mouse Acy1, His tagged Human Cell His
    Mouse Acy1-758M Recombinant Mouse Acy1 Protein, His-tagged Mammalian cells His
    Rat ACY1-497R Recombinant Rat ACY1 Protein Mammalian Cell His
    Zebrafish ACY1-8280Z Recombinant Zebrafish ACY1 Mammalian Cell His
    Human ACY1-725HCL Recombinant Human ACY1 cell lysate Insect Cell N/A
    Mouse ACY1-3095MCL Recombinant Mouse ACY1 cell lysate Human Cell N/A
    Human ACY1-4770H Recombinant Human ACY1 protein, GST-tagged E.coli GST
    Human ACY1-1152H Recombinant Human ACY1 Protein, DDK-tagged Insect Cell DDK
    Human ACY1-1153H Recombinant Human ACY1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human ACY1-4843H Recombinant Human ACY1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human ACY1-487H Recombinant Human ACY1 Protein, His-tagged E.coli His
    Mouse Acy1-424M Recombinant Mouse Acy1 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Mouse Acy1-7144M Recombinant Mouse Acy1 Protein, His-tagged E.coli His

    ACY1 involved in several pathways and played different roles in them. We selected most pathways ACY1 participated on our site, such as Arginine biosynthesis, Metabolic pathways, -Oxocarboxylic acid metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACY1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Arginine biosynthesis GPT; NAGS; NOS2A; GOT2B; ACY1; ARG1; ARG2; GLUD1B; GLUD2; GLUL
    Metabolic pathways NAMPT; SPRA; COMTA; UQCRFS1; AANAT; OGDHA; HSD17B10; CYP2C18; PAFAH1B1A; GOT2
    -Oxocarboxylic acid metabolism ACO1; IDH2; IDH1; GPT; BCAT2; GOT2B; GPT2; BCAT1; AADAT; IDH3B
    Biosynthesis of amino acids PGK1; IDH3B; NAGS; PSAT1; GLULB; ENO2; PKM2; SHMT2; SHMT1; ALDOCB

    ACY1 has several biochemical functions, for example, aminoacylase activity, metal ion binding, metallopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ACY1 itself. We selected most functions ACY1 had, and list some proteins which have the same functions with ACY1. You can find most of the proteins on our site.

    Function Related Protein
    aminoacylase activity ACY3; DARS; ACY1; CAT; ASPA
    metal ion binding RNF169; FAM170A; ADAP2; BRIP1; ESRRGB; SLC2A4RG; TNNI3; NENF; TM9SF1; LIAS
    metallopeptidase activity ADAM10A; BRCC3; Adamts19; LNPEP; ADAMTS16; NAALADL1; BMP1B; AQPEP; NPSN; ADAM2
    protein binding HBZ; AMY1B; BOLA1; TACSTD2; USP54; C10orf46; EIF2S1; AKT2; KLF6; STAG3

    ACY1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACY1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ACY1.

    TERF1; TFAP2A; NPM1; BBS7; BBS4; TTC1; BBS2; POT1; GSTP1

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