Recombinant Human ACY1 Protein, DDK-tagged

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Recombinant Human ACY1 Protein, DDK-tagged

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Cat.No. : ACY1-1152H
Product Overview : Recombinant human ACY1 protein, fused to DDK tag at C-terminus, was expressed in Insect cell.
Description : This gene encodes a cytosolic, homodimeric, zinc-binding enzyme that catalyzes the hydrolysis of acylated L-amino acids to L-amino acids and an acyl group, and has been postulated to function in the catabolism and salvage of acylated amino acids. This gene is located on chromosome 3p21.1, a region reduced to homozygosity in small-cell lung cancer (SCLC), and its expression has been reported to be reduced or undetectable in SCLC cell lines and tumors. The amino acid sequence of human aminoacylase-1 is highly homologous to the porcine counterpart, and this enzyme is the first member of a new family of zinc-binding enzymes. Mutations in this gene cause aminoacylase-1 deficiency, a metabolic disorder characterized by central nervous system defects and increased urinary excretion of N-acetylated amino acids. Alternative splicing of this gene results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ABHD14A (abhydrolase domain containing 14A) gene, as represented in GeneID:100526760. A related pseudogene has been identified on chromosome 18. [provided by RefSeq, Nov 2010].
Source : Insect cells
Species : Human
Tag : DDK
Form : 50 mM Tris.HCl, pH 8.0, 100 mM glycine, 10 % glycerol.
Molecular Mass : 45.7 kDa
Purity : >50 ug/mL as determined by microplate BCA method
Concentration : >50 ug/mL as determined by microplate BCA method
Gene Name : ACY1 aminoacylase 1 [ Homo sapiens ]
Official Symbol : ACY1
Synonyms : ACY-1; ACY1D; HEL-S-5
Gene ID : 95
mRNA Refseq : NM_000666
Protein Refseq : NP_000657
MIM : 104620
UniProt ID : Q03154
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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