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Recombinant Human ACY1, His-tagged

Cat.No. : ACY1-26570TH
Product Overview : Recombinant full length Human Aminoacylase 1 with an N terminal His tag; 428 amino acids including tag, predicted MWt 48kDa.
  • Specification
  • Gene Information
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Description : This gene encodes a cytosolic, homodimeric, zinc-binding enzyme that catalyzes the hydrolysis of acylated L-amino acids to L-amino acids and an acyl group, and has been postulated to function in the catabolism and salvage of acylated amino acids. This gene is located on chromosome 3p21.1, a region reduced to homozygosity in small-cell lung cancer (SCLC), and its expression has been reported to be reduced or undetectable in SCLC cell lines and tumors. The amino acid sequence of human aminoacylase-1 is highly homologous to the porcine counterpart, and this enzyme is the first member of a new family of zinc-binding enzymes. Mutations in this gene cause aminoacylase-1 deficiency, a metabolic disorder characterized by central nervous system defects and increased urinary excretion of N-acetylated amino acids. Alternative splicing of this gene results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ABHD14A (abhydrolase domain containing 14A) gene, as represented in GeneID:100526760. A related pseudogene has been identified on chromosome 18.
Protein length : 408 amino acids
Conjugation : HIS
Molecular Weight : 48.000kDa inclusive of tags
Source : E. coli
Tissue specificity : Expression is highest in kidney, strong in brain and weaker in placenta and spleen.
Form : Liquid
Purity : >90% by SDS-PAGE
Storage buffer : Preservative: NoneConstituents: 10% Glycerol, 20mM Tris HCl, 1mM DTT, pH 8.0
Storage : Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Sequences of amino acids : MGSSHHHHHHSSGLVPRGSHMTSKG PEEEHPSVTLFRQYLRIRTVQPKPD YGAAVAFFEETARQLGLGCQKVEVA PGYVVTVLTWPGTNPTLSSILLNSH TDVVPVFKEHWSHDPFEAFKDSEGY IYARGAQDMKCVSIQYLEAVRRLKV EGHRFPRTIHMTFVPDEEVGGHQGM ELFVQRPEFHALRAGFALDEGIANP TDAFTVFYSERSPWWVRVTSTGRPG HASRFMEDTAAEKLHKVVNSILAFR EKEWQRLQSNPHLKEGSVTSVNLTK LEGGVAYNVIPATMSASFDFRVAPD VDFKAFEEQLQSWCQAAGEGVTLEF AQKWMHPQVTPTDDSNPWWAAFSRV CKDMNLTLEPEIMPAATDNRYIRAV GVPALGFSPMNRTPVLLHDHDERLH EAVFLRGVDIYTRLLPALASVPALP SDS
Sequence Similarities : Belongs to the peptidase M20A family.
Gene ID : ACY1 aminoacylase 1 [ Homo sapiens ]
Official Symbol : ACY1
Synonyms : ACY1; aminoacylase 1; aminoacylase-1;
Gene ID : ACY1 aminoacylase 1 [ Homo sapiens ]
Official Symbol : ACY1
Synonyms : ACY1; aminoacylase 1; aminoacylase-1;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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