ADAM10
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Official Full Name
ADAM metallopeptidase domain 10
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Overview
Members of the ADAM family are cell surface proteins with a unique structure possessing both potential adhesion and protease domains. This gene encodes and ADAM family member that cleaves many proteins including TNF-alpha and E-cadherin. [provided by RefSeq, Jul 2008] -
Synonyms
ADAM10; ADAM metallopeptidase domain 10; RAK; kuz; AD10; AD18; MADM; CD156c; HsT18717; disintegrin and metalloproteinase domain-containing protein 10; CDw156; kuzbanian protein homolog; mammalian disintegrin-metalloprotease; a disintegrin and metalloprotease domain 10;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Chicken
- Homo sapiens (Human)
- Human
- Mouse
- Rat
- CHO
- E.coli
- E.coli expression system
- HEK293
- Mammalian Cell
- Sf21 Insect Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- N
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | ADAM10-924H | Active Recombinant Human ADAM10 Protein, His-tagged | Sf21 Insect Cell | His | Thr214-Glu672 |
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| Human | ADAM10-18H | Active Recombinant Human ADAM10, His-tagged | Sf21 Insect Cell | His |
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| Human | ADAM10-265H | Recombinant Human ADAM 10, His-tagged | E.coli | His |
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| Human | ADAM10-272H | Recombinant Human ADAM10 Protein, GST-tagged | Wheat Germ | GST |
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| Human | ADAM10-7638H | Recombinant Human ADAM10 protein, His-tagged | E.coli | His | Arg420~Val641 (Accession # O14672) |
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| Human | ADAM10-0691H | Recombinant Human ADAM10 Protein (Thr214-Ser504), N-His tagged | E.coli | N-His | Thr214-Ser504 |
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| Human | ADAM10-73H | Recombinant Human ADAM10 Protein, His-tagged | CHO | N-His | Thr214-Glu672 |
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| Mouse | Adam10-961M | Active Recombinant Mouse Adam10 Protein, His-tagged | Sf21 Insect Cell | His | Thr215-Glu673 |
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| Mouse | ADAM10-1275M | Recombinant Mouse ADAM10 Protein | Mammalian Cell | His |
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| Mouse | Adam10-1927M | Recombinant Mouse Adam10, His-tagged | Sf21 Insect Cell | His |
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| Mouse | ADAM10-306M | Recombinant Mouse ADAM10 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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| Mouse | ADAM10-306M-B | Recombinant Mouse ADAM10 Protein Pre-coupled Magnetic Beads | HEK293 |
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| Rat | Adam10-7639R | Recombinant Rat Adam10 protein, His-tagged | E.coli | His | Thr218~Asp445 (Accession # Q10743) |
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| Homo sapiens (Human) | RFL-28202HF | Recombinant Full Length Human Disintegrin And Metalloproteinase Domain-Containing Protein 10(Adam10) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (214-748) |
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| Chicken | ADAM10-5834C | Recombinant Chicken ADAM10 | Mammalian Cell | His |
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- Involved Pathway
- Protein Function
- Interacting Protein
- ADAM10 Related Articles
- ADAM10 Related Research Area
ADAM10 involved in several pathways and played different roles in them. We selected most pathways ADAM10 participated on our site, such as Activated NOTCH1 Transmits Signal to the Nucleus, Alzheimers disease, Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADAM10 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Activated NOTCH1 Transmits Signal to the Nucleus | CNTN1;JAG2;DNER;DLK1;DTX2;JAG1;ADAM10;MIB1 |
| Alzheimers disease | NDUFS1;GRIN2A;NCSTN;GAPDH;UQCRFS1;NDUFB4;NDUFB6;ATP5G1;ITPR1 |
| Axon guidance | PLXNC1;EFNA2A;DUSP2;NRP2;COL9A1B;EPHB4A;EFNB2;UNC5A;ABLIM2 |
| Collagen degradation | COL17A1;MGC174152;MMP20;MGC174857;CTSL1;MMP19;COL13A1;COL19A1;MMP13 |
| Constitutive Signaling by NOTCH1 HD Domain Mutants | JAG1;JAG2;MIB1;ADAM10 |
| Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | JAG2;HDAC5;CDK8;HEYL;ADAM10;HEY1;CCNC;MIB1;HEY2 |
| Constitutive Signaling by NOTCH1 PEST Domain Mutants | HDAC5;HEY1;HEYL;CCNC;JAG1;ADAM10;MIB1;JAG2;CDK8 |
ADAM10 has several biochemical functions, for example, SH3 domain binding, endopeptidase activity, integrin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ADAM10 itself. We selected most functions ADAM10 had, and list some proteins which have the same functions with ADAM10. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| SH3 domain binding | FMNL3;CBLC;PLSCR1;ABI2;HCLS1;UVRAG;SIRPA;SGIP1;KHDRBS2 |
| endopeptidase activity | PSMA7;PSMB5;ADAM10;SENP3;CPS1;PSMA8;PSMA3;MME;PSMA6A |
| integrin binding | THBS1;ICAM3;ITGB1;ITGA6;ESM1;ANXA7;ICAM4;TSPAN4;S1PR3 |
| metalloendopeptidase activity | PAPPAA;ADAM5P;HE1B;MMP23BB;MMP14A;MEP1A;ADAMTS4;PAPPA;ADAMTS3 |
| metallopeptidase activity | MMP2;ADAM1B;MMP13A;XPNPEP2;HE2;BMP1;XPNPEP3;ERAP2;DPP3 |
| protein binding | CPSF2;GOLSYN;NFIL3;COG3;QARS;NASP;C9orf78;FTL;AKT1S1 |
| protein homodimerization activity | CHKA;CUL3;ADH1;RAB11FIP4;ANXA6;CAT;ALX1;APOE;IRAK2 |
| protein kinase binding | BAG5;LLGL1;FAF1;EMP2;TRAF3;XBP1;CD24;MAVS;PPME1 |
| receptor binding | IFNL3;Ar;WNT11R;GNB2L1;ANKRD13C;POU2F1;DRD1A;SERPINE2;GRIN2A |
| zinc ion binding | APOBEC4;ARHGEF2;MMP19;MMP8;TRIM14;SRSF7B;TRIM35-22;CHMP1A;SHARPIN |
ADAM10 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADAM10 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADAM10.
PDIA3; AR; PHB; btuB; pi3p; CD9
- Q&As
- Reviews
Q&As (4)
Ask a questionADAM10 protein can cleave TNF-α and E-cadherin, etc.
The addition of the GST tag helps protect the recombinant protein from extracellular protease degradation and improves its stability.
The protein size of ADAM10 precursor is larger than that of ADAM10 active.
ADAD1 is currently also used in the research of Alzheimer's disease and diabetic retinopathy, etc.
Customer Reviews (3)
Write a reviewDuring the experiment, the technician helped me solve the problems in a timely and accurate manner.
The ADAM10 proteins purchased from your company is suitable for WB.
Received high quality protein products and obtained satisfactory experimental results.
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