ADAM10

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ADAM10

Official Full Name ADAM metallopeptidase domain 10
Background Members of the ADAM family are cell surface proteins with a unique structure possessing both potential adhesion and protease domains. This gene encodes and ADAM family member that cleaves many proteins including TNF-alpha and E-cadherin. [provided by RefSeq, Jul 2008]
Synonyms ADAM10; ADAM metallopeptidase domain 10; RAK; kuz; AD10; AD18; MADM; CD156c; HsT18717; disintegrin and metalloproteinase domain-containing protein 10; CDw156; kuzbanian protein homolog; mammalian disintegrin-metalloprotease; a disintegrin and metalloprotease domain 10;
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • Mammalian Cell
    • Sf21 Insect Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human ADAM10-18H Recombinant Human ADAM10, His-tagged Sf21 Insect Cell His
    Human ADAM10-265H Recombinant Human ADAM 10, His-tagged E.coli His
    Human ADAM10-272H Recombinant Human ADAM10 Protein, GST-tagged Wheat Germ GST
    Human ADAM10-7638H Recombinant Human ADAM10 protein, His-tagged E.coli His
    Human ADAM10-924H Recombinant Human ADAM10 Protein, His-tagged Sf21 Insect Cell His
    Mouse ADAM10-1275M Recombinant Mouse ADAM10 Protein Mammalian Cell His
    Mouse Adam10-1927M Recombinant Mouse Adam10, His-tagged Sf21 Insect Cell His
    Mouse Adam10-961M Recombinant Mouse Adam10 Protein, His-tagged Sf21 Insect Cell His
    Rat Adam10-7639R Recombinant Rat Adam10 protein, His-tagged E.coli His
    Chicken ADAM10-5834C Recombinant Chicken ADAM10 Mammalian Cell His

    ADAM10 involved in several pathways and played different roles in them. We selected most pathways ADAM10 participated on our site, such as Activated NOTCH1 Transmits Signal to the Nucleus, Alzheimers disease, Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADAM10 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Activated NOTCH1 Transmits Signal to the Nucleus DLK1; MIB1; DNER; DTX2; JAG1; JAG2; ADAM10; CNTN1
    Alzheimers disease SDHD; CASP8; SDHB; PPP3R1; COX7A2L; APH1B; NDUFS1; UQCR10; NDUFA13; UQCRC1
    Axon guidance HRAS; NRG4; NCK2; PLXNB2; LIMK1; Sema3f; NFATC2; TRPC3; CDK5; PITPNA
    Collagen degradation CTSK; CTS7; COL13A1; MMP19; MGC174155; MGC174152; ADAM10; COL15A1B; MMP8; MMP20
    Constitutive Signaling by NOTCH1 HD Domain Mutants ADAM10; JAG1; MIB1; JAG2
    Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants HEY1; JAG1; HDAC6; MIB1; HDAC5; JAG2; HEYL; HEY2; CCNC; ADAM10
    Constitutive Signaling by NOTCH1 PEST Domain Mutants HEY1; JAG1; HEY2; HEYL; JAG2; HDAC5; CDK8; ADAM10; HDAC6; CCNC

    ADAM10 has several biochemical functions, for example, SH3 domain binding, endopeptidase activity, integrin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ADAM10 itself. We selected most functions ADAM10 had, and list some proteins which have the same functions with ADAM10. You can find most of the proteins on our site.

    Function Related Protein
    SH3 domain binding ADAM19; EPS15; PTPN12; INPPL1; PTPN22; CRB3; SHANK2; SH3BP5; SH3BP5L; VASP
    endopeptidase activity PSMB11; PSMB6; PSMB9B; KLK1B24; APH1C; PSMB5; PSEN1; TPP1; MMP3; PSMA7
    integrin binding ANGPTL3; ICAM4; AMICA1; THBS1; ICAM5; THBS4; NISCH; THY1; WISP1; TLN1
    metalloendopeptidase activity C6AST4; ADAM8A; ADAMTS4; BMP1A; MEP1A.1; UQCRC2A; ADAMDEC1; PAPPAA; BMP1; ADAM1B
    metallopeptidase activity PAPLNB; MMP14B; C6AST3; ACY1; PAPPA; YME1L1; Npepo; STAMBP; XPNPEP2; ADAM17
    protein binding PPP2R5D; ECH1; SMAD7; EXOC4; KRTAP9-4; RPUSD3; HMGB2; ADI1; POLG; MED12
    protein homodimerization activity TIMELESS; PDXK; PRPS2; SMAD4; PKD2; TFAP4; DAXX; GDF6; APOBEC3G; TCF3B
    protein kinase binding GSK3B; PRC1; GCSAM; AP2A2; NIPAL1; SPDYE2; ACTA2; MLKL; PDPK1; AXIN2
    receptor binding EDN3; ARRB2; CCL2; FGF6A; HACL1; NTF3; NMU; POMC; BMP3; CSK
    zinc ion binding CA4A; NEURL3; SLU7; PTPN1; FHL2; MICAL1; PHF14; LHX1A; ZNF385D; CSRP1

    ADAM10 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADAM10 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADAM10.

    PDIA3; AR; PHB; btuB; pi3p; CD9

    Martin, RK; Brooks, KB; et al. Antigen Transfer from Exosomes to Dendritic Cells as an Explanation for the Immune Enhancement Seen by IgE Immune Complexes. PLOS ONE 9:-(2014).
    Sampedro, GR; DeDent, AC; et al. Targeting Staphylococcus aureus alpha-Toxin as a Novel Approach to Reduce Severity of Recurrent Skin and Soft-Tissue Infections. JOURNAL OF INFECTIOUS DISEASES 210:1012-1018(2014).

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