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Official Full Name ADAM metallopeptidase domain 2
Background This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This member is a subunit of an integral sperm membrane glycoprotein called fertilin, which plays an important role in sperm-egg interactions.
Synonyms ADAM2; ADAM metallopeptidase domain 2; fertilin beta , FTNB; disintegrin and metalloproteinase domain-containing protein 2; cancer/testis antigen 15; CT15; PH 30b; PH30; A disintegrin and metalloproteinase domain 2; ADAM 2; ADAM2_HUMAN; AI323749; CRYN1; CRYN2; Fertilin beta; Fertilin subunit beta; Ftnb; PH 30; PH-30; Ph30 beta; PH30-beta; OTTHUMP00000225677; OTTHUMP00000225678; OTTHUMP00000225679; OTTHUMP00000225680; PH-30b
    • Species :
    • Cynomolgus Monkey
    • Human
    • Mouse
    • Rat
    • Source :
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human ADAM2-22HCL Recombinant Human ADAM2 cell lysate N/A
    Human ADAM2-26137TH Recombinant Human ADAM2 Wheat Germ N/A
    Human ADAM2-26413TH Recombinant Human ADAM2 Wheat Germ N/A
    Human ADAM2-279H Recombinant Human ADAM2 Protein, GST-tagged Wheat Germ GST
    Human ADAM2-280H Recombinant Human ADAM2 Protein, GST-tagged Wheat Germ GST
    Mouse ADAM2-1284M Recombinant Mouse ADAM2 Protein Mammalian Cell His
    Rat ADAM2-503R Recombinant Rat ADAM2 Protein Mammalian Cell His
    Cynomolgus Monkey ADAM2-276C Recombinant Cynomolgus ADAM2 Protein, His-tagged Mammalian Cell His

    ADAM2 involved in several pathways and played different roles in them. We selected most pathways ADAM2 participated on our site, such as Fertilization, Interaction With The Zona Pellucida, Reproduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADAM2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Fertilization Acr; CATSPERB; ADAM21; ADAM20; CATSPER1; IZUMO1; ZP3; TMEM146; CATSPERG1; ADAM30
    Interaction With The Zona Pellucida ZP2; ADAM30; ADAM2; OVGP1; ADAM20; ZP3; ADAM21
    Reproduction IZUMO1; CATSPERG1; ADAM21; CATSPERG2; ZP2; HVCN1; ADAM2; ZP3; CATSPER2; Acr

    ADAM2 has several biochemical functions, for example, integrin binding, metalloendopeptidase activity, metallopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ADAM2 itself. We selected most functions ADAM2 had, and list some proteins which have the same functions with ADAM2. You can find most of the proteins on our site.

    Function Related Protein
    integrin binding ADAM23; ITGB6; ITGA5; WISP1A; ECM2; AMICA1; WISP3; ADAM2; GFAP; ADAMTS5
    metalloendopeptidase activity MBTPS2; ADAM33; MMP11; ADAM8A; ADAM8; IDE; MMP3; ADAM17A; MEP1A; HE2
    metallopeptidase activity BMP1B; ADAM10; MYSM1; PGCP; CLCA3; ADAM15; ADAM12; ADAM18; MMP14B; CNDP1
    zinc ion binding OTUD7A; AGBL1; RECQL4; RNF17; MMP11; MMP19; TOP3A; RNF121; ZDHHC13; TCF19

    ADAM2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADAM2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADAM2.

    Desiderio, UV; Zhu, XL; et al. ADAM2 Interactions with Mouse Eggs and Cell Lines Expressing alpha(4)/alpha(9) (ITGA4/ITGA9) Integrins: Implications for Integrin-Based Adhesion and Fertilization. PLOS ONE 5:-(2010).
    Murase, SI; Cho, C; et al. ADAM2 promotes migration of neuroblasts in the rostral migratory stream to the olfactory bulb. EUROPEAN JOURNAL OF NEUROSCIENCE 27:1585-1595(2008).

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