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ADAM2

  • Official Full Name

    ADAM metallopeptidase domain 2

  • Overview

    This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This member is a subunit of an integral sperm membrane glycoprotein called fertilin, which plays an important role in sperm-egg interactions.
  • Synonyms

    ADAM2; ADAM metallopeptidase domain 2; fertilin beta , FTNB; disintegrin and metalloproteinase domain-containing protein 2; cancer/testis antigen 15; CT15; PH 30b; PH30; A disintegrin and metalloproteinase domain 2; ADAM 2; ADAM2_HUMAN; AI323749; CRYN1; CRYN2; Fertilin beta; Fertilin subunit beta; Ftnb; PH 30; PH-30; Ph30 beta; PH30-beta; OTTHUMP00000225677; OTTHUMP00000225678; OTTHUMP00000225679; OTTHUMP00000225680; PH-30b;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Antibody
  • Protein Pre-coupled Magnetic Beads
  • Bos taurus (Bovine)
  • Cynomolgus Monkey
  • Human
  • Mouse
  • Rat
  • E.coli expression system
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ADAM2-280H Recombinant Human ADAM2 Protein, GST-tagged Wheat Germ GST
Human ADAM2-279H Recombinant Human ADAM2 Protein, GST-tagged Wheat Germ GST
Human ADAM2-22HCL Recombinant Human ADAM2 cell lysate N/A
Human ADAM2-11HF Recombinant Full Length Human ADAM2 Protein In Vitro Cell Free System 716 amino acids
Human ADAM2-26137TH Recombinant Human ADAM2 Wheat Germ N/A 100 amino acids
Human ADAM2-871HF Recombinant Full Length Human ADAM2 Protein, GST-tagged In Vitro Cell Free System GST 716 amino acids
Human ADAM2-26413TH Recombinant Human ADAM2 Wheat Germ N/A 716 amino acids
Mouse ADAM2-1284M Recombinant Mouse ADAM2 Protein Mammalian Cell His
Mouse ADAM2-312M-B Recombinant Mouse ADAM2 Protein Pre-coupled Magnetic Beads HEK293
Mouse ADAM2-312M Recombinant Mouse ADAM2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat ADAM2-503R Recombinant Rat ADAM2 Protein Mammalian Cell His
Rat ADAM2-159R Recombinant Rat ADAM2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat ADAM2-159R-B Recombinant Rat ADAM2 Protein Pre-coupled Magnetic Beads HEK293
Bos taurus (Bovine) RFL-16767BF Recombinant Full Length Bovine Disintegrin And Metalloproteinase Domain-Containing Protein 2(Adam2) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (175-745)
Cynomolgus Monkey ADAM2-276C Recombinant Cynomolgus ADAM2 Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey ADAM2-26C Recombinant Cynomolgus Monkey ADAM2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Cynomolgus Monkey ADAM2-26C-B Recombinant Cynomolgus Monkey ADAM2 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ADAM2 Related Articles

ADAM2 involved in several pathways and played different roles in them. We selected most pathways ADAM2 participated on our site, such as Fertilization, Interaction With The Zona Pellucida, Reproduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADAM2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
FertilizationCATSPERG1;CATSPER2;ADAM20;ADAM2;IZUMO1;IZUMO4;CATSPERG2;HVCN1;ADAM21
Interaction With The Zona PellucidaADAM21;ADAM2;ZP2;ZP3;ADAM30;OVGP1;ADAM20
ReproductionCATSPER3;CATSPER1;CATSPER2;HVCN1;ZP2;ADAM2;CATSPERG1;IZUMO4;OVGP1

ADAM2 has several biochemical functions, for example, integrin binding, metalloendopeptidase activity, metallopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ADAM2 itself. We selected most functions ADAM2 had, and list some proteins which have the same functions with ADAM2. You can find most of the proteins on our site.

Function Related Protein
integrin bindingPTPN2;SRC;ICAM4;THBS4;ADAMTS13;ACTN1;ICAM2;ADAM10;CTGF
metalloendopeptidase activityBMP1;MMP30;MIPEP;ADAMTS20;MMP11;MME;MMP14A;GM12824;ADAMDEC1
metallopeptidase activityADAM18;CLCA5;AQPEP;COPS5;GM5136;CLCA2;MMP2;ADAM23;AFG3L2
zinc ion bindingGALT;LPXN;CTCF;CA13;ZDHHC19;NUP153;GATA4;NEURL1AA;ZMYM2

ADAM2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADAM2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADAM2.

Desiderio, UV; Zhu, XL; et al. ADAM2 Interactions with Mouse Eggs and Cell Lines Expressing alpha(4)/alpha(9) (ITGA4/ITGA9) Integrins: Implications for Integrin-Based Adhesion and Fertilization. PLOS ONE 5:-(2010).
Murase, SI; Cho, C; et al. ADAM2 promotes migration of neuroblasts in the rostral migratory stream to the olfactory bulb. EUROPEAN JOURNAL OF NEUROSCIENCE 27:1585-1595(2008).
  • Q&As
  • Reviews

Q&As (5)

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What is ADAM2 also known as? 10/17/2022

ADAM2 also known as PH-30 β or fertilin β.

Where is the cellular localization of ADAM2? 07/21/2021

ADAM2 is localized in the cell membrane.

Where is ADAM2 synthesized? 07/10/2021

ADAM2 is synthesized in the testes and processed during sperm maturation.

What is the biological function of ADAM2? 06/12/2021

ADAM2 contribute to sperm-sperm adhesion, sperm-egg interactions, and the migration of sperm in the female reproductive tract.

What are the effects of ADAM2 deficiency? 11/17/2020

ADAM2 deficiency causes sterility in male mice.

Customer Reviews (3)

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Reviews
06/18/2021

    The technician was very professional and helped me solve many problems that arose in my experiments.

    01/26/2021

      Customer service is always online and able to answer my questions in a timely manner.

      07/11/2020

        High protein concentration and good quality for my experimental needs.

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