AK2
-
Official Full Name
adenylate kinase 2
-
Overview
Adenylate kinases are involved in regulating the adenine nucleotide composition within a cell by catalyzing the;reversible transfer of phosphate groups among adenine nucleotides. Three isozymes of adenylate kinase, namely 1, 2,;and 3, have been identified in vertebrates; this gene encodes isozyme 2. Expression of these isozymes is;tissue-specific and developmentally regulated. Isozyme 2 is localized in the mitochondrial intermembrane space and may;play a role in apoptosis. Mutations in this gene are the cause of reticular dysgenesis. Alternate splicing results in;multiple transcript variants. Pseudogenes of this gene are found on chromosomes 1 and 2. -
Synonyms
AK2; adenylate kinase 2; adenylate kinase 2, mitochondrial; ATP-AMP transphosphorylase 2; adenylate kinase isoenzyme 2, mitochondrial; ADK2; AK 2;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- Rhesus Macaque
- Zebrafish
- E.coli
- E.Coli or Yeast
- HEK293
- HEK293T
- In Vitro Cell Free System
- Insect Cell
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- His|GST
- Myc
- DDK
- MYC
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- AK2 Related Articles
- AK2 Related Gene Family
AK2 involved in several pathways and played different roles in them. We selected most pathways AK2 participated on our site, such as Purine metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with AK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
---|---|
Purine metabolism | POLA2;TWISTNB;POLR3G;PKMB;PRPS2;PDE11A;IMPDH1B;AK3;NME2 |
Metabolic pathways | ATP6V1E1;PNP;B4GALT4;IL4I1;PIGK;ACOX3;CYP2C55;NDST3;ATP6V1E1B |
AK2 has several biochemical functions, for example, ATP binding, adenylate kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by AK2 itself. We selected most functions AK2 had, and list some proteins which have the same functions with AK2. You can find most of the proteins on our site.
Function | Related Protein |
---|---|
ATP binding | SMARCAL1;MAP3K4;DDX47;MAPK8A;ACVR1B;MAPK1;BUB1B;EPHA3;BCR |
adenylate kinase activity | AK4;AK5;AK7;AK2;AK1;AK8 |
AK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of AK2.
EIF1B; GH1; EPB41; NME2; MCC; PAK2; IKBKE; ACTR6; TRAF6; ABCC5; ABCC6; topA; VCAM1
- Q&As
- Reviews
Q&As (13)
Ask a questionCurrently, there are no FDA-approved drugs targeting AK2 specifically. However, ongoing research is exploring the development of AK2 inhibitors as potential anti-cancer therapies.
Some studies suggest that certain natural compounds and dietary factors, such as resveratrol, quercetin, and curcumin, can modulate AK2 protein activity. These compounds are known to exhibit antioxidant and anti-inflammatory properties, and their effects on AK2 activity may contribute to their potential health benefits.
AK2 protein activity can be regulated at multiple levels. It can be modulated by post-translational modifications, such as phosphorylation and acetylation, which can affect its enzymatic activity and protein stability. The expression of AK2 can also be regulated by various factors, including hormones, growth factors, and environmental stimuli.
AK2 protein is commonly studied using techniques such as gene cloning, recombinant protein expression, and enzymatic assays. Researchers also use cell and animal models to investigate the physiological and pathological roles of AK2 in various biological processes.
AK2 protein expression levels can vary in different cancer types. Some studies have reported elevated AK2 expression in certain cancers, including leukemia, breast cancer, and colorectal cancer. However, more research is needed to fully understand the role of AK2 in cancer development and progression.
AK2 can interact with various proteins in the cellular network, forming protein complexes involved in energy metabolism and other cellular processes. For example, it can interact with other enzymes involved in ATP production and utilization, as well as proteins involved in mitochondrial function and signaling pathways.
Besides its role in energy metabolism, AK2 protein has been implicated in other cellular processes, such as DNA replication and repair, apoptosis (programmed cell death), and signal transduction. It may also play a role in maintaining cellular redox balance and regulating cellular differentiation.
Mutations in the AK2 gene have been associated with several diseases, including reticular dysgenesis, a rare immunodeficiency disorder. In these cases, the dysfunctional AK2 enzyme impairs the production of ATP, leading to impaired immune system development and function.
Further research on AK2 protein may focus on understanding its role in cellular energy metabolism, exploring its involvement in other diseases, and developing targeted therapies to modulate its activity for therapeutic purposes.
As of now, there are no clinical trials specifically targeting AK2 protein. However, preclinical studies continue to explore the potential of AK2 inhibitors as therapeutic agents, particularly in cancer treatment. These inhibitors aim to disrupt the altered energy metabolism of cancer cells, which may provide a basis for future clinical trials.
AK2 protein has gained attention as a potential therapeutic target for certain diseases. Inhibiting AK2 activity may be beneficial in specific cancer types, as cancer cells often rely on altered energy metabolism for their growth and survival.
AK2 protein itself is not commonly used as a diagnostic marker for diseases. However, mutations in the AK2 gene have been linked to certain genetic disorders, such as reticular dysgenesis, and genetic testing for these mutations can be used for diagnostic purposes.
AK2 protein is found in various tissues and organs throughout the body, including the heart, brain, liver, and skeletal muscles.
Customer Reviews (3)
Write a reviewThe remarkable traits of the AK2 protein, combined with the manufacturer's top-tier assistance, allows me to delve deeper into my research objectives
With the AK2 protein in my arsenal and the unwavering support of the manufacturer's technical team, I am empowered to overcome any hurdles that may obstruct my progress.
With an unrivaled depth of knowledge and expertise, ensuring a seamless and successful research experience.
Ask a Question for All AK2 Products
Required fields are marked with *
My Review for All AK2 Products
Required fields are marked with *