Recombinant Human AP3B1, GST-tagged
|Product Overview :||Recombinant Human AP3B1 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.|
- Gene Information
- Related Products
|Description :||This gene encodes a protein that may play a role in organelle biogenesis associated with melanosomes, platelet dense granules, and lysosomes. The encoded protein is part of the heterotetrameric AP-3 protein complex which interacts with the scaffolding protein clathrin. Mutations in this gene are associated with Hermansky-Pudlak syndrome type 2. Two transcript variants encoding different isoforms have been found for this gene.|
|Protein length :||763-1094a.a.|
|Storage :||The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.|
|Storage Buffer :||1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.|
|Gene Name :||AP3B1 adaptor-related protein complex 3, beta 1 subunit [ Homo sapiens ]|
|Official Symbol :||AP3B1|
|Synonyms :||AP3B1; adaptor-related protein complex 3, beta 1 subunit; AP-3 complex subunit beta-1; ADTB3A; HPS2; beta3A-adaptin; beta-3A-adaptin; AP-3 complex beta-3A subunit; adaptor protein complex AP-3 subunit beta-1; adapter-related protein complex 3 subunit beta-1; clathrin assembly protein complex 3 beta-1 large chain; PE; HPS; ADTB3;|
|Gene ID :||8546|
|mRNA Refseq :||NM_003664|
|Protein Refseq :||NP_003655|
|UniProt ID :||O00203|
|Chromosome Location :||5q14.1|
|Pathway :||Clathrin derived vesicle budding, organism-specific biosystem; Golgi Associated Vesicle Biogenesis, organism-specific biosystem; Lysosome, organism-specific biosystem; Lysosome, conserved biosystem; Membrane Trafficking, organism-specific biosystem; trans-Golgi Network Vesicle Budding, organism-specific biosystem;|
|Function :||binding; protein phosphatase binding; protein transporter activity;|
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Q&As (10)Ask a question
The study of recombinant AP3B1 may help us better understand and treat diseases associated with abnormal intracellular vesicle transport.
The AP3B1 should be frozen at -80°C to ensure its long-term stability.
At present, there is no clear evidence that the AP3B1 has anti-tumor effect, but it may have a certain application prospect in the field of tumor therapy.
The recombinant AP3B1 protein can be used as a carrier to help transport drugs to specific organelles or tissues, thereby improving the efficiency of drug delivery.
AP3B1 can be expressed, extracted and purified in cells by genetic engineering technology.
The current study shows that the AP3B1 does not cause a significant immune response in most people.
Mutations in the AP3B1 gene can lead to an inherited neurodevelopmental disorder, AP-3 associated intracellular transport deficiency. AP3B1 research may contribute to the treatment and understanding of related diseases.
AP3B1 has potential application in disease treatment, drug delivery and other fields, but it is still in the research stage.
AP3B1 can bind to specific cell membrane proteins, and has certain targeting effects in vitro and in vivo.
The current study shows that the AP3B1 is safe at appropriate doses. Of course, further confirmation is needed before clinical application.
Customer Reviews (4)Write a review
The stability of the protein is tested by long-term storage or storage under different conditions, such as temperature, pH value, etc. -
The cytotoxicity of the protein is detected through the effect on cells to ensure the safety of the protein. -
The molecular weight of the protein and whether there are impurities were detected by SDS-PAGE, Western blot and other methods. -
The activity of protein, such as enzyme activity and binding activity, was detected by functional experiments. -
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