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APLN

  • Official Full Name

    apelin

  • Overview

    This gene encodes a peptide that functions as an endogenous ligand for the G protein coupled receptor APJ. The encoded protein is synthesized as a prepropeptide that is processed into biologically active C-terminal fragments. The peptide fragments activate different tissue specific signaling pathways that regulate diverse biological functions including fluid homeostasis, cardiovascular function and insulin secretion. This protein also functions as a coreceptor for the human immunodeficiency virus 1.
  • Synonyms

    APLN; apelin; apelin, AGTRL1 ligand; XNPEP2; AGTRL1 ligand; APEL; APEL_HUMAN; Apelin-13; APJ endogenous ligand;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • His|GST
  • His|MBP
  • His|S
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human AAPLN-505H Recombinant Human AAPLN protein, GST-tagged Wheat Germ GST
Human APLN-3549H Recombinant Human APLN, His-tagged, S tagged E.coli His/S 77
Human APLN-8261H Recombinant Human APLN protein, His-tagged E.coli His Ser24~Phe77 (Accession # Q9ULZ1)
Human APLN-685H Recombinant Human APLN protein, GST-tagged Wheat Germ GST
Human APLN-8262H Recombinant Human APLN protein, His & MBP-tagged E.coli His/MBP Ser24~Phe77
Human APLN-8792HCL Recombinant Human APLN 293 Cell Lysate HEK293 N/A
Human APLN-301470H Recombinant Human APLN protein, GST-tagged E.coli GST Asn38-Phe77
Human APLN-0102H Recombinant Human APLN Protein (Ser24-Phe77), N-GST-tagged E.coli N-GST Ser24-Phe77
Human APLN-1070HF Recombinant Full Length Human APLN Protein, GST-tagged In Vitro Cell Free System GST 122 amino acids
Human APLN-1071HF Recombinant Full Length Human APLN Protein, GST-tagged In Vitro Cell Free System GST 77 amino acids
Mouse Apln-8263M Recombinant Mouse Apln protein, His & GST-tagged E.coli His/GST Val23~Phe77 (Accession # Q9R0R4)
Rat APLN-714R Recombinant Rat APLN Protein Mammalian Cell His
Rat Apln-8264R Recombinant Rat Apln protein, His & S-tagged E.coli His/S Ala19~Phe77 (Accession # Q9R0R3)
Rat APLN-370R Recombinant Rat APLN Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat APLN-370R-B Recombinant Rat APLN Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque APLN-357R Recombinant Rhesus monkey APLN Protein, His-tagged Mammalian Cell His
Rhesus Macaque APLN-186R Recombinant Rhesus Macaque APLN Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque APLN-186R-B Recombinant Rhesus Macaque APLN Protein Pre-coupled Magnetic Beads HEK293
Zebrafish APLN-7588Z Recombinant Zebrafish APLN Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

APLN involved in several pathways and played different roles in them. We selected most pathways APLN participated on our site, such as Class A/1 (Rhodopsin-like receptors), G alpha (i) signalling events, GPCR downstream signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with APLN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Class A/1 (Rhodopsin-like receptors)OPN1SW;OPN4A;SSTR2;NPB;FFAR3;NMBA;GPR31B;MLN;ADORA3
G alpha (i) signalling eventsCCR3;POMCB;SSTR3;TAS2R7;RGR;GPR55A;ADORA3;RLN3A;PNOC
GPCR downstream signalingRLN2;OPN4B;OXGR1A.1;GPR68;RGS10;EDN1;FPR-RS6;EDNRA;HRH3
GPCR ligand bindingS1PR3;CCR1;GPRC6A;PTH2;AGTR2;TAAR1;OPN4;GPR4;RAMP3
Peptide ligand-binding receptorsSSTR5;PROKR1;NMBB;CXCL11.8;CCL27;NMBA;GAL;CCL19A.2;AMCF-II
Signal TransductionPRLH;TLE3B;C;IQGAP3;USP4;VIP;RDH7;RGS18;IQCE
Signaling by GPCROPN4B;PROK1;RGS6;GPBAR1;ARHGEF3;ARHGEF18A;TAC2;NMBA;OXTRL

APLN has several biochemical functions, for example, G-protein coupled receptor binding, apelin receptor binding, hormone activity. Some of the functions are cooperated with other proteins, some of the functions could acted by APLN itself. We selected most functions APLN had, and list some proteins which have the same functions with APLN. You can find most of the proteins on our site.

Function Related Protein
G-protein coupled receptor bindingARRB2;AKAP5;GNA14;USP20;S1PR1;GNA11B;RSPO3;RSPO1;PSAPL1
apelin receptor binding
hormone activityPRL2A1;ADCYAP1A;APLN;CALCA;GCGA;GCGB;IGF2B;ADIPOQ;STC2A
receptor bindingFGF18A;ABL2;LAMA2;ABCA1;INSL3;TMEM38A;PTK2B;AMN;CX3CL1

APLN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with APLN here. Most of them are supplied by our site. Hope this information will be useful for your research of APLN.

MDFI

  • Q&As
  • Reviews

Q&As (10)

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Does the study of APLN involve genetic engineering technology? 12/06/2022

Yes, genetic engineering techniques are often used to produce APLN s.

Does APLN interact with other drugs? 09/27/2022

There may be interactions, and it is recommended to avoid concurrent use of other drugs during use, especially those that affect the cardiovascular system.

What is the action mechanism of APLN ? 05/25/2022

APLN promotes cardiovascular protection and anti-tumor effects by binding to APJ receptors.

In what diseases might APLN have potential applications? 04/15/2022

APLN has potential applications in the treatment of cardiovascular diseases, tumors and metabolic diseases.

In what way can APLN be administered? 05/07/2021

APLN can be administered intravenously or subcutaneously.

What is the dose of APLN to treat cardiovascular disease? 02/19/2021

Dosage should be determined according to the specific situation, it is recommended to consult with a professional doctor.

Does the development of APLN involve animal experiments? 05/03/2020

In the development process, it usually goes through a series of animal experiments to verify its effectiveness and safety.

What are the side effects of APLN ? 02/17/2020

Common side effects include injection site pain, fever, nausea, etc., but most patients tolerate them well.

What is the protective effect of APLN on cardiovascular diseases? 01/15/2020

APLN can promote blood vessel dilation, inhibit inflammatory response, and facilitate the survival and repair of cardiomyocytes.

Has the application of APLN in tumor therapy been clinically verified? 01/18/2019

There are currently no large-scale clinical trials to confirm its use in cancer treatment, but preliminary research results are promising.

Customer Reviews (3)

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Reviews
12/16/2022

    Western blot experiments using this protein can obtain clearly distinguishable bands, indicating that it has high clarity and legibility.

    02/10/2022

      In the course of repeated experiments, the stability of this protein has remained consistent, which provides us with great convenience.

      12/12/2019

        I appreciate the manufacturer's pursuit of product quality, and their product repeatability is very good, which makes me more confident in the experimental results.

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