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Official Full Name apelin
Background This gene encodes a peptide that functions as an endogenous ligand for the G protein coupled receptor APJ. The encoded protein is synthesized as a prepropeptide that is processed into biologically active C-terminal fragments. The peptide fragments activate different tissue specific signaling pathways that regulate diverse biological functions including fluid homeostasis, cardiovascular function and insulin secretion. This protein also functions as a coreceptor for the human immunodeficiency virus 1.
Synonyms APLN; apelin; apelin, AGTRL1 ligand; XNPEP2; AGTRL1 ligand; APEL; APEL_HUMAN; Apelin-13; APJ endogenous ligand
    • Species :
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • MBP
    • S
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human APLN-301470H Recombinant Human APLN protein, GST-tagged E.coli GST
    Human AAPLN-505H Recombinant Human AAPLN protein, GST-tagged Wheat Germ GST
    Human APLN-3549H Recombinant Human APLN, His-tagged, S tagged E.coli His/S
    Human APLN-685H Recombinant Human APLN protein, GST-tagged Wheat Germ GST
    Human APLN-8261H Recombinant Human APLN protein, His-tagged E.coli His
    Human APLN-8262H Recombinant Human APLN protein, His & MBP-tagged E.coli His/MBP
    Human APLN-8792HCL Recombinant Human APLN 293 Cell Lysate HEK293 N/A
    Mouse Apln-8263M Recombinant Mouse Apln protein, His & GST-tagged E.coli His/GST
    Rat APLN-714R Recombinant Rat APLN Protein Mammalian Cell His
    Rat Apln-8264R Recombinant Rat Apln protein, His & S-tagged E.coli His/S
    Rhesus Macaque APLN-357R Recombinant Rhesus monkey APLN Protein, His-tagged Mammalian Cell His
    Zebrafish APLN-7588Z Recombinant Zebrafish APLN Mammalian Cell His

    APLN involved in several pathways and played different roles in them. We selected most pathways APLN participated on our site, such as Class A/1 (Rhodopsin-like receptors), G alpha (i) signalling events, GPCR downstream signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with APLN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Class A/1 (Rhodopsin-like receptors) GPBAR1; LPAR2B; ADRA2B; DRD2; PNOCB; GPR77; CCR6; PYYA; EDNRA; MLN
    G alpha (i) signalling events CXCR7B; OXER1; RHOL; RGS20; HRH3; DRD4; ADORA3; GPR55; CCR3; RLN3
    GPCR downstream signaling ADRA2C; RGS14; CCR6; ARHGEF17; PTGDR2; FGD2; OPN1SW; CCL19A.2; CCL27; TAC2
    GPCR ligand binding GPR39; RLN2; APLN; OXGR1; SSTR5; CCR3; NPFF; PROK1; GPRC6A; PENK
    Peptide ligand-binding receptors PNOC; PROK2; TAC3; TAC1; CCL19A.2; MLN; KISS1; NMBA; CCL35.1; CXCR7B
    Signal Transduction LGR6; CLIP3; NOXO1; DCLRE1B; NET1; SH2B3; RGS21; BCL9L; DHRS9; FGD4
    Signaling by GPCR OPN4A; GNA13B; S1PR5B; GPR37L1; PRLH; ARHGAP4A; PENKA; OXGR1A.1; RGS12; GPR4

    APLN has several biochemical functions, for example, G-protein coupled receptor binding, apelin receptor binding, hormone activity. Some of the functions are cooperated with other proteins, some of the functions could acted by APLN itself. We selected most functions APLN had, and list some proteins which have the same functions with APLN. You can find most of the proteins on our site.

    Function Related Protein
    G-protein coupled receptor binding HAND2; PICK1; GNA12A; RSPO2; CORT; PSAP; GNA11A; GNAT2; QRFP; NPFF
    apelin receptor binding APLN
    hormone activity INSB; PRL7D1; PRL7A2; UTS1; GALP; PRL3B1; LEPA; INHBA; PRL3C1; BMP10
    receptor binding IL29; ARPP19A; LTB; TIGIT; HSPA1B; NTF7; HSD17B4; SRPX2; FGF11A; EDN3

    APLN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with APLN here. Most of them are supplied by our site. Hope this information will be useful for your research of APLN.


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