|Official Full Name||apelin|
|Background||This gene encodes a peptide that functions as an endogenous ligand for the G protein coupled receptor APJ. The encoded protein is synthesized as a prepropeptide that is processed into biologically active C-terminal fragments. The peptide fragments activate different tissue specific signaling pathways that regulate diverse biological functions including fluid homeostasis, cardiovascular function and insulin secretion. This protein also functions as a coreceptor for the human immunodeficiency virus 1.|
|Synonyms||APLN; apelin; apelin, AGTRL1 ligand; XNPEP2; AGTRL1 ligand; APEL; APEL_HUMAN; Apelin-13; APJ endogenous ligand|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
APLN involved in several pathways and played different roles in them. We selected most pathways APLN participated on our site, such as Class A/1 (Rhodopsin-like receptors), G alpha (i) signalling events, GPCR downstream signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with APLN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Class A/1 (Rhodopsin-like receptors)||OXTRL; NMS; LTB4R; NPSR1; AGTR2; SST; NPB; ADORA1; OPN5; SSTR4|
|G alpha (i) signalling events||RGS4; ADORA1; SOUL3; RGS10; FPR-RS4; RGS18; RGS19; SSTR2; SSTR3; OPN5|
|GPCR downstream signaling||EDN2; RGS1; SST; RGS7; AKAP13; CXCL13; SST1.1; CNR1; DGKQ; ANXA1B|
|GPCR ligand binding||NPS; HEBP1; PNOC; LTB4R; PENKB; FZD10; LPAR2A; CCR3; FFAR3; TAS2R13|
|Peptide ligand-binding receptors||PYY; KISS1; MLN; GPR37B; PROK1; PROKR1A; PYYA; RLN3; HCRT; ZFPM2B|
|Signal Transduction||DNER; CXCR7B; RGS6; ARHGAP32; NPSR1; RHOT1B; FSTL1B; DACT1; ARAP1; RGS18|
|Signaling by GPCR||PENKA; OR10A5; RGS4; PENK; GPBAR1; OXGR1A.3; PROK1; RGS20; SST1.1; PRLH|
APLN has several biochemical functions, for example, G-protein coupled receptor binding, apelin receptor binding, hormone activity. Some of the functions are cooperated with other proteins, some of the functions could acted by APLN itself. We selected most functions APLN had, and list some proteins which have the same functions with APLN. You can find most of the proteins on our site.
|G-protein coupled receptor binding||FCN1; PSAPL1; GNAV1; NMS; HSPA1A; GNA11B; USP33; STUB1; NPFFL; ITGB4|
|apelin receptor binding||APLN|
|hormone activity||SST1.1; IGF2A; PRL6A1; GNRH3; STC2; BMP10; BNP; RLN3; PRL7A2; CALCA|
|receptor binding||LIF; HFE2; MPV17L; MAP7; SEMA4D; PLXNC1; HLA-F; TNFSF13B; ANGPTL2; PSPN|
APLN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with APLN here. Most of them are supplied by our site. Hope this information will be useful for your research of APLN.