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Recombinant Human APLN protein, His-tagged

Cat.No. : APLN-8261H
Product Overview : Recombinant Human APLN aa. (Ser24~Phe77 (Accession # Q9ULZ1)) fused with N-terminal His tag was produced in E. coli cells.
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  • Gene Information
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Description : This gene encodes a peptide that functions as an endogenous ligand for the G-protein coupled apelin receptor. The encoded preproprotein is proteolytically processed into biologically active C-terminal peptide fragments. These peptide fragments activate different tissue specific signaling pathways that regulate diverse biological functions including fluid homeostasis, cardiovascular function and insulin secretion. This protein also functions as a coreceptor for the human immunodeficiency virus 1.
Source : E. coli
Species : Human
Tag : His
Form : Freeze-dried powder
Molecular Mass : 10kDa as determined by SDS-PAGE reducing conditions.
Protein length : Ser24~Phe77 (Accession # Q9ULZ1)
Endotoxin : <1.0EU per 1ug (determined by the LAL method)
Purity : >95%
Characteristic : The isoelectric point is 11.9.
Applications : SDS-PAGE; WB; ELISA; IP.
Stability : The thermal stability is described by the loss rate of the target protein. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. (Referring from China Biological Products Standard, which was calculated by the Arrhenius equation.) The loss of this protein is less than 5% within the expiration date under appropriate storage condition.
Storage : Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
Storage Buffer : Supplied as lyophilized form in 20mM Tris, 500mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% sarcosyl, 5% trehalose, and preservative.
Reconstitution : Reconstitute in ddH2O.
Gene Name : APLN apelin [ Homo sapiens (human) ]
Official Symbol : APLN
Synonyms : APLN; apelin; APEL; XNPEP2; AGTRL1 ligand; APJ endogenous ligand
Gene ID : 8862
mRNA Refseq : NM_017413.4
Protein Refseq : NP_059109.3
UniProt ID : Q9ULZ1

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (10)

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Does the study of APLN involve genetic engineering technology? 12/06/2022

Yes, genetic engineering techniques are often used to produce APLN s.

Does APLN interact with other drugs? 09/27/2022

There may be interactions, and it is recommended to avoid concurrent use of other drugs during use, especially those that affect the cardiovascular system.

What is the action mechanism of APLN ? 05/25/2022

APLN promotes cardiovascular protection and anti-tumor effects by binding to APJ receptors.

In what diseases might APLN have potential applications? 04/15/2022

APLN has potential applications in the treatment of cardiovascular diseases, tumors and metabolic diseases.

In what way can APLN be administered? 05/07/2021

APLN can be administered intravenously or subcutaneously.

What is the dose of APLN to treat cardiovascular disease? 02/19/2021

Dosage should be determined according to the specific situation, it is recommended to consult with a professional doctor.

Does the development of APLN involve animal experiments? 05/03/2020

In the development process, it usually goes through a series of animal experiments to verify its effectiveness and safety.

What are the side effects of APLN ? 02/17/2020

Common side effects include injection site pain, fever, nausea, etc., but most patients tolerate them well.

What is the protective effect of APLN on cardiovascular diseases? 01/15/2020

APLN can promote blood vessel dilation, inhibit inflammatory response, and facilitate the survival and repair of cardiomyocytes.

Has the application of APLN in tumor therapy been clinically verified? 01/18/2019

There are currently no large-scale clinical trials to confirm its use in cancer treatment, but preliminary research results are promising.

Customer Reviews (3)

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Reviews
12/16/2022

    Western blot experiments using this protein can obtain clearly distinguishable bands, indicating that it has high clarity and legibility.

    02/10/2022

      In the course of repeated experiments, the stability of this protein has remained consistent, which provides us with great convenience.

      12/12/2019

        I appreciate the manufacturer's pursuit of product quality, and their product repeatability is very good, which makes me more confident in the experimental results.

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