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Official Full Name 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
Background ATIC (AICAR transformylase/IMP cyclohydrolase) belongs to the purH family, expressed in the cytoplasm, predicted molecular weight approximately 65 kD. ATIC catalyzes the penultimate and final steps in the de novo purine nucleotide biosynthesis pathway. AT
Synonyms ATIC; 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase; bifunctional purine biosynthesis protein PURH; AICARFT; IMPCHASE; phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PURH; AICARFT/IMPCHAS
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • MYC/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human ATIC-24H Recombinant Human ATIC protein, His-tagged E.coli His
    Human ATIC-25H Recombinant Human ATIC protein, GST-tagged E.coli GST
    Human ATIC-27034TH Recombinant Human ATIC Wheat Germ N/A
    Human ATIC-4383H Recombinant Human ATIC Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human ATIC-8618HCL Recombinant Human ATIC 293 Cell Lysate HEK293 N/A
    Human ATIC-952H Recombinant Human ATIC protein, GST-tagged Wheat Germ GST
    Mouse ATIC-2090M Recombinant Mouse ATIC Protein Mammalian Cell His
    Mouse Atic-365M Recombinant Mouse Atic Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Rat ATIC-847R Recombinant Rat ATIC Protein Mammalian Cell His
    Chicken ATIC-6733C Recombinant Chicken ATIC Mammalian Cell His
    Zebrafish ATIC-5208Z Recombinant Zebrafish ATIC Mammalian Cell His

    ATIC involved in several pathways and played different roles in them. We selected most pathways ATIC participated on our site, such as Purine metabolism, One carbon pool by folate, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATIC were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Purine metabolism NT5M; NUDT9; NME2B.2; NME7; POLR3E; NT5E; NT5C1BA; POLE4; POLR2I; POLE3
    One carbon pool by folate ATIC; ALDH1L2; SHMT2; MTHFD2L; MTHFS; AMT; MTHFD2; DHFRL1; MTHFD1B; TYMS
    Metabolic pathways GNPDA1; DGKE; PLCB1; POLR2I; IDS; MDH2; PRIM2; SLC27A5; RDH10; PHYKPL

    ATIC has several biochemical functions, for example, IMP cyclohydrolase activity, phosphoribosylaminoimidazolecarboxamide formyltransferase activity, protein homodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ATIC itself. We selected most functions ATIC had, and list some proteins which have the same functions with ATIC. You can find most of the proteins on our site.

    Function Related Protein
    IMP cyclohydrolase activity ATIC
    phosphoribosylaminoimidazolecarboxamide formyltransferase activity ATIC
    protein homodimerization activity PEX7; GCH1; GSS; MFF; NKX2-5; SMAD4; TG; OLFM4; SPATA24; BCL2A1A

    ATIC has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATIC here. Most of them are supplied by our site. Hope this information will be useful for your research of ATIC.

    HNRNPDL; PSTPIP1; SNRPA; NME2; ME2; CDK2; STOM; VHL; ELF3; IKBKE; CMBL; RADIL; NDUFAF1; TRAF6; EGFR; rbsC; q7cgs8_yerpe; q81sa6_bacan; ere_dna

    Lima, A; Monteiro, J; et al. Prediction of Methotrexate Clinical Response in Portuguese Rheumatoid Arthritis Patients: Implication of MTHFR rs1801133 and ATIC rs4673993 Polymorphisms. BIOMED RESEARCH INTERNATIONAL :-(2014).
    Li, XQ; Hisaoka, M; et al. Expression of anaplastic lymphoma kinase in soft tissue tumors: An immunohistochemical and molecular study of 249 cases. HUMAN PATHOLOGY 35:711-721(2004).

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