ATP5B
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Official Full Name
ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide
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Overview
This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel consists of three main subunits (a, b, c). This gene encodes the beta subunit of the catalytic core. -
Synonyms
ATP5B; ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide; ATPSB; ATP synthase subunit beta, mitochondrial; mitochondrial; ATP 5B; ATP synthase subunit beta; ATP synthase subunit beta mitochondrial; ATPB; ATPB_HUMAN; ATPMB; Mitochondrial ATP Synthase Subunit Beta; Mitochondrial ATP synthetase beta subunit; OTTHUMP00000243448; OTTHUMP00000243449; OTTHUMP00000243452; mitochondrial ATP synthase beta subunit; mitochondrial ATP synthetase, beta subunit;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- Zebrafish
- E.coli
- E.Coli or Yeast
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- Yeast
- GST
- His
- Fc
- Avi
- Myc
- SUMO
- DDK
- Non
- Involved Pathway
- Protein Function
- Interacting Protein
ATP5B involved in several pathways and played different roles in them. We selected most pathways ATP5B participated on our site, such as Oxidative phosphorylation, Metabolic pathways, Alzheimers disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATP5B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Oxidative phosphorylation | ctaG;NDUFS3;NDUFB8;COX8C;ATP6V1B1;COX7B2;ATP5S;ATP6V1C2;UQCRC2B |
| Metabolic pathways | CHIA;DLAT;IDH2;PCYT1BB;UGT1A4;CYP2A12;GRHPR;PNLIPRP1;SPHK2 |
| Alzheimers disease | PSEN2;GRIN1;CALM1;ATP5G3;NDUFA9;NDUFA4L2;NAE1;NDUFS1;LRP1 |
| Parkinsons disease | PRKACG;MT-ND4;NDUFA13;PARK7;CASP9;GNAI1;NDUFA4L2;COX6B2;NDUFB5 |
| Huntingtons disease | HIP1;SP1;REST;SOD2;UCP1;NDUFC2;CREB5;ATP5G3;HDAC1 |
ATP5B has several biochemical functions, for example, ATP binding, contributes_to ATPase activity, MHC class I protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ATP5B itself. We selected most functions ATP5B had, and list some proteins which have the same functions with ATP5B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | GC3;YES1;MYLK3;MYLK4;MAP3K13;IP6K2;GTF2F2B;CHUK;PRKACB |
| contributes_to ATPase activity | ATP5O;ATP5A1;RUVBL2;ATP5C1;ATP5D;ABCA7;ATP5F1;ATP5E;PPP2R4 |
| MHC class I protein binding | ATP5B;TUBB4B;CD8A;TUBB;PILRB2;Pilrb1;BCAP31;HLA-E;LILRB1 |
| protein binding | ANK2;KIF23;EPB41L1;RIPPLY2;UBE2Q1;PTRH1;cgr2b;PRKRIR;SREK1 |
| proton-transporting ATP synthase activity, rotational mechanism | ATP5O;ATP5A1;ATP6AP1B;ATP5C1;ATP6V0C;ATP6AP1;ATP5B;ATP5E |
| proton-transporting ATPase activity, rotational mechanism | ATP6V0C;ATP6V1C1;ATP5C1;ATP6V1AA;ATP6V0CA;ATP6V0A1A;ATP5E;ATP5A1;TCIRG1 |
| transmembrane transporter activity | RALBP1;SLC2A9L1;SLC2A15A;ATP5H;SLC22A7A;SLC22A7B.1;AQP1;ATP5E;SV2C |
| transporter activity | ABCC6;AQP12B;SLC5A10;OSTB;TCOF1;CRABP1B;OCA2;TIMM9;TMEM184C |
ATP5B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATP5B here. Most of them are supplied by our site. Hope this information will be useful for your research of ATP5B.
YWHAZ; ESR1; vpu; ATP5F1; PPP1CC; YWHAG; SIRT3; IKBKG; RPP14; TK1; CDK4; ANXA7; HMOX2; CDKN1A; PSME3; PIN1
- Reviews
- Q&As
Customer Reviews (3)
Write a reviewThe outstanding quality of proteins lies in their strong biological activity and their high purity during production, which is really rare.
ATP5B has a very short half-life and shows a very high clearance rate, which makes its biological activity more stable.
Because the production process is efficient and environmentally friendly, recombinant proteins can be produced on a large scale without negative environmental impacts.
Q&As (6)
Ask a questionATP5B gene mutation frequency may be different in different diseases and populations, which needs further study.
It plays an important role in the nervous system and is associated with certain nervous system diseases such as Parkinson's disease and cerebral ischemia.
This gene mutations may lead to abnormal protein structure or function, which in turn affects the physiological function of the protein and is associated with specific diseases.
ATP5B expression and function are affected by a variety of regulatory mechanisms, including regulation of transcription factors and epigenetic modifications.
Assessment of the effect of ATP5B mutations on disease often requires a comprehensive analysis of gene sequencing, protein function studies, and clinical and epidemiological studies.
It is highly expressed in multiple tissues and organs, especially metabolically active tissues such as heart, liver, and brain.
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