Recombinant Mouse Atp5b, His-tagged

Cat.No. : Atp5b-3710M
Product Overview : ATP synthase subunit beta, mitochondrial (Atp5b)
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Description : Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core, and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F1. Rotation of the central stalk against the surrounding alpha3beta3 subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.
Source : E. Coli or Yeast
Species : Mouse
Tag : His
Form : This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
Protein length : 529
Purity : >90%(SDS-PAGE)
Notes : Small volumes of Atp5b recombinant protein may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice.
Storage : Store at -20 degree C. For extended storage, store at -20 or -80 degree C.Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4 deg. C for up to one week.
Storage Buffer : PBS pH 7.4, 50% glycerol
Warning : This product is for research use only. Not for use in diagnostic or therapeutic procedures.
Gene Name : Atp5b ATP synthase, H+ transporting mitochondrial F1 complex, beta subunit [ Mus musculus ]
Official Symbol : Atp5b
Synonyms : ATP5B; ATP synthase, H+ transporting mitochondrial F1 complex, beta subunit; ATP synthase subunit beta, mitochondrial; mitochondrial ATP synthase, H+ transporting F1 complex beta subunit; ATP synthase, H+ transporting mitochondrial F1 complex, alpha subunit;
Gene ID : 11947
mRNA Refseq : NM_016774
Protein Refseq : NP_058054
Chromosome Location : 10 D3; 10
Pathway : Alzheimers disease, organism-specific biosystem; Alzheimers disease, conserved biosystem; Electron Transport Chain, organism-specific biosystem; F-type ATPase, eukaryotes, organism-specific biosystem; Formation of ATP by chemiosmotic coupling, organism-sp
Function : ATP binding; ATPase activity; MHC class I protein binding; calcium ion binding; eukaryotic cell surface binding; hydrogen ion transporting ATP synthase activity, rotational mechanism; hydrogen-exporting ATPase activity, phosphorylative mechanism; hydrolase activity; hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances; lipoprotein particle receptor activity; nucleoside-triphosphatase activity; nucleotide binding; proton-transporting ATPase activity, rotational mechanism;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.


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Customer Reviews (3)

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    The outstanding quality of proteins lies in their strong biological activity and their high purity during production, which is really rare.


      ATP5B has a very short half-life and shows a very high clearance rate, which makes its biological activity more stable.


        Because the production process is efficient and environmentally friendly, recombinant proteins can be produced on a large scale without negative environmental impacts.

        Q&As (6)

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        What is the frequency of ATP5B mutations? 07/09/2022

        ATP5B gene mutation frequency may be different in different diseases and populations, which needs further study.

        How about the link between ATP5B protein and neurological diseases? 02/07/2021

        It plays an important role in the nervous system and is associated with certain nervous system diseases such as Parkinson's disease and cerebral ischemia.

        How are ATP5B mutations associated with disease? 10/15/2020

        This gene mutations may lead to abnormal protein structure or function, which in turn affects the physiological function of the protein and is associated with specific diseases.

        What are the regulatory mechanisms of ATP5B? 06/29/2020

        ATP5B expression and function are affected by a variety of regulatory mechanisms, including regulation of transcription factors and epigenetic modifications.

        How to evaluate the effect of ATP5B gene mutation on disease? 03/03/2019

        Assessment of the effect of ATP5B mutations on disease often requires a comprehensive analysis of gene sequencing, protein function studies, and clinical and epidemiological studies.

        In which tissues or organs is ATP5B highly expressed? 01/15/2019

        It is highly expressed in multiple tissues and organs, especially metabolically active tissues such as heart, liver, and brain.

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