Recombinant Full Length Human ATP5B Protein, GST-tagged

Cat.No. : ATP5B-1339HF
Product Overview : Human ATP5B full-length ORF ( NP_001677.2, 1 a.a. - 529 a.a.) recombinant protein with GST-tag at N-terminal.
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Description : This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel consists of three main subunits (a, b, c). This gene encodes the beta subunit of the catalytic core. [provided by RefSeq, Jul 2008]
Source : In Vitro Cell Free System
Species : Human
Tag : GST
Molecular Mass : 83 kDa
Protein Length : 529 amino acids
AA Sequence : MLGFVGRVAA APASGALRRL TPSASLPPAQ LLLRAAPTAV HPVRDYAAQT SPSPKAGAAT GRIVAVIGAV VDVQFDEGLP PILNALEVQG RETRLVLEVA QHLGESTVRT IAMDGTEGLV RGQKVLDSGA PIKIPVGPET LGRIMNVIGE PIDERGPIKT KQFAPIHAEA PEFMEMSVEQ EILVTGIKVV DLLAPYAKGG KIGLFGGAGV GKTVLIMELI NNVAKAHGGY SVFAGVGERT REGNDLYHEM IESGVINLKD ATSKVALVYG QMNEPPGARA RVALTGLTVA EYFRDQEGQD VLLFIDNIFR FTQAGSEVSA LLGRIPSAVG YQPTLATDMG TMQERITTTK KGSITSVQAI YVPADDLTDP APATTFAHLD ATTVLSRAIA ELGIYPAVDP LDSTSRIMDP NIVGSEHYDV ARGVQKILQD YKSLQDIIAI LGMDELSEED KLTVSRARKI QRFLSQPFQV AEVFTGHMGK LVPLKETIKG FQQILAGEYD HLPEQAFYMV GPIEEAVAKA DKLAEEHSS
Applications : Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCl, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Gene Name : ATP5B ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide [ Homo sapiens ]
Official Symbol : ATP5B
Synonyms : ATP5B; ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide; ATPSB; ATP synthase subunit beta, mitochondrial; mitochondrial ATP synthase beta subunit; mitochondrial ATP synthetase, beta subunit; ATPMB; MGC5231
Gene ID : 506
mRNA Refseq : NM_001686
Protein Refseq : NP_001677
MIM : 102910
UniProt ID : P06576

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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05/22/2020

    The outstanding quality of proteins lies in their strong biological activity and their high purity during production, which is really rare.

    04/25/2020

      ATP5B has a very short half-life and shows a very high clearance rate, which makes its biological activity more stable.

      04/07/2019

        Because the production process is efficient and environmentally friendly, recombinant proteins can be produced on a large scale without negative environmental impacts.

        Q&As (6)

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        What is the frequency of ATP5B mutations? 07/09/2022

        ATP5B gene mutation frequency may be different in different diseases and populations, which needs further study.

        How about the link between ATP5B protein and neurological diseases? 02/07/2021

        It plays an important role in the nervous system and is associated with certain nervous system diseases such as Parkinson's disease and cerebral ischemia.

        How are ATP5B mutations associated with disease? 10/15/2020

        This gene mutations may lead to abnormal protein structure or function, which in turn affects the physiological function of the protein and is associated with specific diseases.

        What are the regulatory mechanisms of ATP5B? 06/29/2020

        ATP5B expression and function are affected by a variety of regulatory mechanisms, including regulation of transcription factors and epigenetic modifications.

        How to evaluate the effect of ATP5B gene mutation on disease? 03/03/2019

        Assessment of the effect of ATP5B mutations on disease often requires a comprehensive analysis of gene sequencing, protein function studies, and clinical and epidemiological studies.

        In which tissues or organs is ATP5B highly expressed? 01/15/2019

        It is highly expressed in multiple tissues and organs, especially metabolically active tissues such as heart, liver, and brain.

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