Recombinant Human AXL protein, His-tagged
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| Cat.No. : | AXL-770H |
| Product Overview : | Recombinant Human AXL protein (Ala26-Pro449), fused to His tag at C-terminus, was expressed in human 293 cells (HEK293). |
| Description : | AXL Receptor Tyrosine Kinase is also known as Tyrosine-protein kinase receptor UFO, which belongs to the protein kinase superfamily, Tyr protein kinase family and AXL/UFO subfamily. AXL contains two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains and one protein kinase domain. AXL is highly expressed in metastatic colon tumors. AXL is activated by GAS6-binding and subsequent autophosphorylation. AXL is involved in signal transduction from the extracellular matrix into the cytoplasm by binding growth factors, and thus implicated in the stimulation of cell proliferation. |
| Source : | HEK293 |
| Species : | Human |
| Tag : | His |
| Form : | Lyophilized from 0.22 um filtered solution in PBS, pH7.4, 10% trehalose. |
| Molecular Mass : | The protein has a calculated MW of 46.6 kDa. The protein migrates as 60-70 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. |
| Protein length : | 424 |
| Endotoxin : | Less than 1.0 EU per ug by the LAL method. |
| Purity : | >95% as determined by SDS-PAGE. |
| Storage : |
For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower. Please avoid repeated freeze-thaw cycles. This product is stable after storage at: -20 centigrade to -70 centigrade for 12 months in lyophilized state; -70 centigrade for 3 months under sterile conditions after reconstitution. |
| Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4ºC before opening to recover the entire contents. |
| SDS-PAGE of AXL-770H : |
Human Axl, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%. |
| Gene Name : | AXL |
| Official Symbol : | AXL |
| Synonyms : | AXL; AXL receptor tyrosine kinase; tyrosine-protein kinase receptor UFO; JTK11; UFO; AXL oncogene; oncogene AXL; AXL transforming sequence/gene |
| Gene ID : | 558 |
| mRNA Refseq : | NM_001699 |
| Protein Refseq : | NP_001690 |
| MIM : | 109135 |
| UniProt ID : | P30530 |
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◆ Lysates
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