|Official Full Name||B-cell CLL/lymphoma 6|
|Background||The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of START-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Sep 2008]|
|Synonyms||BCL6; B-cell CLL/lymphoma 6; BCL5; LAZ3; BCL6A; ZNF51; ZBTB27; B-cell lymphoma 6 protein; BCL-5; BCL-6; protein LAZ-3; zinc finger protein 51; B-cell lymphoma 5 protein; B-cell lymphoma 6 protein transcript; zinc finger transcription factor BCL6S; cys-his2 zinc finger transcription factor; zinc finger and BTB domain-containing protein 27; lymphoma-associated zinc finger gene on chromosome 3;|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
bcl6 involved in several pathways and played different roles in them. We selected most pathways bcl6 participated on our site, such as FoxO signaling pathway, Transcriptional misregulation in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with bcl6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|FoxO signaling pathway||INS2; FOXO4; IRS4; TGFB3; MAPK8; IL7R; S1PR1; PTENA; TGFBR1; MAP2K1|
|Transcriptional misregulation in cancer||MYCN; PFTK1; PAX3; RXRA; SSX1; MET; NR4A3; ZBTB16; HIST1H3F; FUS|
bcl6 has several biochemical functions, for example, RNA polymerase II regulatory region sequence-specific DNA binding, chromatin DNA binding, chromatin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by bcl6 itself. We selected most functions bcl6 had, and list some proteins which have the same functions with bcl6. You can find most of the proteins on our site.
|RNA polymerase II regulatory region sequence-specific DNA binding||XBP1; LMO2; ZNF549; PRDM12B; GATA2; OSR2; MSX1; ACTN4; CEBPB; BCL6|
|chromatin DNA binding||CLOCK; SRF; HIST1H1A; FOXC2; AASS; MYOG; HIST1H1D; PER1; HIST1H1C; GATA1|
|chromatin binding||ISL1; SMARCD3; STAG1; ZFP143; POLD1; ZMYND11; STAT5B; HESX1; SKOR2; PRKAA2|
|intronic transcription regulatory region sequence-specific DNA binding||NKX2-1; BCL6; GRHL2|
|metal ion binding||NTHL1; NDUFS2; GMEB2; RNF150A; ZIC2B; PARP12; NDUFV1; CALUB; BMPR1BA; MYLIPA|
|protein binding||CUL4A; ZNF32; RPS6KA5; LARP1; PLXND1; FBXL14; ARHGAP44; NUMBL; BCKDK; RFESD|
|sequence-specific DNA binding||TP53; HOXA9; NR4A1; NR6A1; DLX4; DBX1B; POU3F1; KLF2; HOXD1; POU3F2A|
|transcription factor activity, sequence-specific DNA binding||TRP53; ZFP131; SOX11; L3MBTL4; RFXANK; RFX1A; HOXD3A; FOXO1A; ZNF484; ZFP354B|
|transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding||CSDA; CDX2; SNAI3; BCL6AB; ARHGAP35; PCGF6; PURB; AEBP1; JARID2; ZEB1|
bcl6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with bcl6 here. Most of them are supplied by our site. Hope this information will be useful for your research of bcl6.
BCL6B; ZBTB7B; LIMS3L; AES; TRAF1; SIAH1; KIFC3