bcl6 Protein, B-cell CLL/lymphoma 6

bcl6

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bcl6

Official Full Name B-cell CLL/lymphoma 6
Background The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of START-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Sep 2008]
Synonyms BCL6; B-cell CLL/lymphoma 6; BCL5; LAZ3; BCL6A; ZNF51; ZBTB27; B-cell lymphoma 6 protein; BCL-5; BCL-6; protein LAZ-3; zinc finger protein 51; B-cell lymphoma 5 protein; B-cell lymphoma 6 protein transcript; zinc finger transcription factor BCL6S; cys-his2 zinc finger transcription factor; zinc finger and BTB domain-containing protein 27; lymphoma-associated zinc finger gene on chromosome 3;
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Trx
    • MYC/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Mouse Bcl6-701M Recombinant Mouse Bcl6 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Human BCL6-10185H Recombinant Human BCL6, GST-tagged E.coli GST
    Human BCL6-148H Recombinant Human B-cell CLL/lymphoma 6 E.coli His
    Human BCL6-158H Recombinant Human BCL6 Protein E.coli N/A
    Human BCL6-159H Recombinant Human BCL6 Protein Wheat Germ GST
    Human BCL6-252H Recombinant Human BCL6, His & Trx-tagged E.coli His/Trx
    Human BCL6-26735TH Recombinant Human BCL6 Protein, GST-tagged E.coli GST
    Human BCL6-8479HCL Recombinant Human BCL6 293 Cell Lysate HEK293 N/A
    Mouse BCL6-2351M Recombinant Mouse BCL6 Protein Mammalian Cell His
    Rhesus Macaque BCL6-524R Recombinant Rhesus monkey BCL6 Protein, His-tagged Mammalian Cell His
    Chicken BCL6-2143C Recombinant Chicken BCL6 Mammalian Cell His

    bcl6 involved in several pathways and played different roles in them. We selected most pathways bcl6 participated on our site, such as FoxO signaling pathway, Transcriptional misregulation in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with bcl6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    FoxO signaling pathway INS2; FOXO4; IRS4; TGFB3; MAPK8; IL7R; S1PR1; PTENA; TGFBR1; MAP2K1
    Transcriptional misregulation in cancer MYCN; PFTK1; PAX3; RXRA; SSX1; MET; NR4A3; ZBTB16; HIST1H3F; FUS

    bcl6 has several biochemical functions, for example, RNA polymerase II regulatory region sequence-specific DNA binding, chromatin DNA binding, chromatin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by bcl6 itself. We selected most functions bcl6 had, and list some proteins which have the same functions with bcl6. You can find most of the proteins on our site.

    Function Related Protein
    RNA polymerase II regulatory region sequence-specific DNA binding XBP1; LMO2; ZNF549; PRDM12B; GATA2; OSR2; MSX1; ACTN4; CEBPB; BCL6
    chromatin DNA binding CLOCK; SRF; HIST1H1A; FOXC2; AASS; MYOG; HIST1H1D; PER1; HIST1H1C; GATA1
    chromatin binding ISL1; SMARCD3; STAG1; ZFP143; POLD1; ZMYND11; STAT5B; HESX1; SKOR2; PRKAA2
    intronic transcription regulatory region sequence-specific DNA binding NKX2-1; BCL6; GRHL2
    metal ion binding NTHL1; NDUFS2; GMEB2; RNF150A; ZIC2B; PARP12; NDUFV1; CALUB; BMPR1BA; MYLIPA
    protein binding CUL4A; ZNF32; RPS6KA5; LARP1; PLXND1; FBXL14; ARHGAP44; NUMBL; BCKDK; RFESD
    sequence-specific DNA binding TP53; HOXA9; NR4A1; NR6A1; DLX4; DBX1B; POU3F1; KLF2; HOXD1; POU3F2A
    transcription factor activity, sequence-specific DNA binding TRP53; ZFP131; SOX11; L3MBTL4; RFXANK; RFX1A; HOXD3A; FOXO1A; ZNF484; ZFP354B
    transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding CSDA; CDX2; SNAI3; BCL6AB; ARHGAP35; PCGF6; PURB; AEBP1; JARID2; ZEB1

    bcl6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with bcl6 here. Most of them are supplied by our site. Hope this information will be useful for your research of bcl6.

    BCL6B; ZBTB7B; LIMS3L; AES; TRAF1; SIAH1; KIFC3

    Basso, K; Dalla-Favera, R; et al. Germinal centres and B cell lymphomagenesis. NATURE REVIEWS IMMUNOLOGY 15:172-184(2015).
    Gao, FJ; Yang, YY; et al. BRAD4 plays a critical role in germinal center response by regulating Bcl-6 and NF-kappa B activation. CELLULAR IMMUNOLOGY 294:1-8(2015).

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