Recombinant Human BCL6, GST-tagged
Cat.No. : | BCL6-10185H |
Product Overview : | Recombinant Human BCL6 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose. |
Availability | February 08, 2025 |
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Species : | Human |
Source : | E.coli |
Tag : | GST |
ProteinLength : | 183-532a.a. |
Description : | The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of START-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. |
Storage : | The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles. |
Storage Buffer : | 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol. |
Gene Name | BCL6 B-cell CLL/lymphoma 6 [ Homo sapiens ] |
Official Symbol | BCL6 |
Synonyms | BCL6; B-cell CLL/lymphoma 6; zinc finger protein 51 , ZNF51; B-cell lymphoma 6 protein; BCL5; BCL6A; LAZ3; ZBTB27; BCL-5; BCL-6; protein LAZ-3; zinc finger protein 51; B-cell lymphoma 5 protein; B-cell lymphoma 6 protein transcript; zinc finger transcription factor BCL6S; cys-his2 zinc finger transcription factor; zinc finger and BTB domain-containing protein 27; lymphoma-associated zinc finger gene on chromosome 3; ZNF51; |
Gene ID | 604 |
mRNA Refseq | NM_001130845 |
Protein Refseq | NP_001124317 |
MIM | 109565 |
UniProt ID | P41182 |
Chromosome Location | 3q27 |
Pathway | B Cell Receptor Signaling Pathway, organism-specific biosystem; Direct p53 effectors, organism-specific biosystem; FoxO family signaling, organism-specific biosystem; IL4-mediated signaling events, organism-specific biosystem; Signaling events mediated by HDAC Class II, organism-specific biosystem; Transcriptional misregulation in cancer, organism-specific biosystem; Transcriptional misregulation in cancer, conserved biosystem; |
Function | chromatin DNA binding; chromatin binding; metal ion binding; protein binding; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; zinc ion binding; |
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Not For Human Consumption!
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