Recombinant Human BCL6 Protein, GST-tagged
Cat.No. : | BCL6-26735TH |
Product Overview : | Recombinant Human BCL6(aa 1-150) fused with GST tag was expressed in E. coli. |
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Description : | Bcl-6 proto-oncogene product (a Kruppel-type zinc-finger protein) is mainly expressed in normal germinal center B cells and related lymphomas. Bcl-6 is involved in chromosome rearrangements at 3q27 in non-Hodgkin’s lymphomas and Bcl-6 rearrangements have been detected in 33%-45% of diffuse large B cell lymphomas. Bcl-6 has been detected immunohistochemically in follicular lymphomas, diffuse large B cell lymphomas, Burkitt’s lymphomas and in nodular, lymphocyte predominant Hodgkin’s disease. |
Source : | E. coli |
Species : | Human |
Tag : | GST |
Form : | Bcl-6 protein in 50mM Tris-HCl, pH7.5 and 10mM L-glutathione (reduced). |
Molecular Mass : | 43kDa band on SDS-PAGE (Including GST tag). |
Storage : | Store vial at -20 centigrade to -80 centigrade. When stored at the recommended temperature, this protein is stable for 12 months. Please prevent freeze-thaw cycles. |
Protein length : | 1-150 |
Gene Name : | BCL6 B-cell CLL/lymphoma 6 [ Homo sapiens ] |
Official Symbol : | BCL6 |
Synonyms : | BCL6; B-cell CLL/lymphoma 6; zinc finger protein 51 , ZNF51; B-cell lymphoma 6 protein; BCL5; BCL6A; LAZ3; ZBTB27; BCL-5; BCL-6; protein LAZ-3; zinc finger protein 51; B-cell lymphoma 5 protein; B-cell lymphoma 6 protein transcript; zinc finger transcription factor BCL6S; cys-his2 zinc finger transcription factor; zinc finger and BTB domain-containing protein 27; lymphoma-associated zinc finger gene on chromosome 3; ZNF51; |
Gene ID : | 604 |
mRNA Refseq : | NM_001130845 |
Protein Refseq : | NP_001124317 |
MIM : | 109565 |
UniProt ID : | P41182 |
Products Types
◆ Recombinant Protein | ||
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◆ Lysates | ||
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Not For Human Consumption!
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Customer Reviews (3)
Write a reviewIts stability and structural integrity make it an ideal candidate for studying protein structures at high resolution.
I am delighted to highly recommend the BCL6 Protein for researchers seeking excellent performance in Western blotting (WB) experiments and protein electron microscopy structure analysis
Its exceptional purity and integrity ensure clear and reliable bands, enabling accurate detection and quantification of target proteins.
Q&As (5)
Ask a questionChallenges include the need to develop specific and effective inhibitors of BCL6 function while minimizing off-target effects and ensuring tolerability in clinical settings.
Yes, genetic mutations and translocations involving the BCL6 gene have been linked to the development of certain lymphomas and other hematological malignancies.
BCL6 protein is crucial for the formation and maintenance of germinal centers, where it regulates the processes of somatic hypermutation and class-switch recombination in B cells.
Targeting BCL6 protein could potentially offer new therapeutic options by modulating immune responses and suppressing the aberrant production of autoantibodies in autoimmune diseases.
Yes, the assessment of BCL6 protein expression can provide valuable prognostic information, helping to predict patient outcomes and guide treatment strategies for lymphoma patients.
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