Recombinant Human BCL6, His & Trx-tagged
Cat.No. : | BCL6-252H |
Product Overview : | Recombinant Human BCL6(Met 1-Met 150) fussed with His & Trx tag at N-terminal was expressed in E. coli. |
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Description : | The protein encoded by this gene is an evolutionarily conserved 95-kDa protein containing six C-terminal zinc-finger motifs and an N-terminal POZ domain. It has been reported that BCL-6 is present in DNA-binding complexes in nuclear extracts from various B-cell lines. There are many relationships between non-Hodgkin's lymphoma, diffuse large cell lymphoma and BCL6’s translocations. BCL6 can repress transcription from promoters linked to its DNA target sequence and this activity is dependent upon specific DNA-binding and the presence of an intact N-terminal half of the protein. |
Source : | E. coli |
Species : | Human |
Tag : | His&Trx |
Predicted N Terminal : | Met |
Form : | Lyophilized from sterile 20mM Tris, 10% glycerol, pH 8.0 |
Molecular Mass : | The recombinant human BCL6/Trx fusion protein consisting of 309 amino acids and has a calculated molecular mass of 34.2 kDa. It migrates as an approximately 33 kDa band in SDS-PAGE under reducing conditions. |
Purity : | > 92 % as determined by SDS-PAGE |
Stability : | Samples are stable for up to twelve months from date of receipt at -70 centigrade |
Storage : | Store it under sterile conditions at -20 centigrade to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Protein length : | Met1-Met150 |
Gene Name : | BCL6 B-cell CLL/lymphoma 6 [ Homo sapiens ] |
Official Symbol : | BCL6 |
Synonyms : | BCL5; LAZ3; BCL6A; ZNF51; ZBTB27; B-cell lymphoma 6 protein; B-cell lymphoma 5 protein; B-cell lymphoma 6 protein transcript; BCL-5; BCL-6; cys-his2 zinc finger transcription factor; lymphoma-associated zinc finger gene on chromosome 3; protein LAZ-3; zinc finger and BTB domain-containing protein 27; zinc finger protein 51; zinc finger transcription factor BCL6S |
Gene ID : | 604 |
mRNA Refseq : | NM_001130845 |
Protein Refseq : | NP_001124317 |
MIM : | 109565 |
UniProt ID : | P41182 |
Chromosome Location : | 3q27 |
Pathway : | B Cell Receptor Signaling Pathway, organism-specific biosystem; DNA damage response (only ATM dependent), organism-specific biosystem; FoxO family signaling, organism-specific biosystem |
Function : | RNA polymerase II regulatory region sequence-specific DNA binding; chromatin DNA binding; metal ion binding |
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Not For Human Consumption!
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Customer Reviews (3)
Write a reviewIts stability and structural integrity make it an ideal candidate for studying protein structures at high resolution.
I am delighted to highly recommend the BCL6 Protein for researchers seeking excellent performance in Western blotting (WB) experiments and protein electron microscopy structure analysis
Its exceptional purity and integrity ensure clear and reliable bands, enabling accurate detection and quantification of target proteins.
Q&As (5)
Ask a questionChallenges include the need to develop specific and effective inhibitors of BCL6 function while minimizing off-target effects and ensuring tolerability in clinical settings.
Yes, genetic mutations and translocations involving the BCL6 gene have been linked to the development of certain lymphomas and other hematological malignancies.
BCL6 protein is crucial for the formation and maintenance of germinal centers, where it regulates the processes of somatic hypermutation and class-switch recombination in B cells.
Targeting BCL6 protein could potentially offer new therapeutic options by modulating immune responses and suppressing the aberrant production of autoantibodies in autoimmune diseases.
Yes, the assessment of BCL6 protein expression can provide valuable prognostic information, helping to predict patient outcomes and guide treatment strategies for lymphoma patients.
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