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Recombinant Human BCL6, His & Trx-tagged

Cat.No. : BCL6-252H
Product Overview : Recombinant Human BCL6(Met 1-Met 150) fussed with His & Trx tag at N-terminal was expressed in E. coli.
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Description : The protein encoded by this gene is an evolutionarily conserved 95-kDa protein containing six C-terminal zinc-finger motifs and an N-terminal POZ domain. It has been reported that BCL-6 is present in DNA-binding complexes in nuclear extracts from various B-cell lines. There are many relationships between non-Hodgkin's lymphoma, diffuse large cell lymphoma and BCL6’s translocations. BCL6 can repress transcription from promoters linked to its DNA target sequence and this activity is dependent upon specific DNA-binding and the presence of an intact N-terminal half of the protein.
Source : E. coli
Species : Human
Tag : His&Trx
Predicted N Terminal : Met
Form : Lyophilized from sterile 20mM Tris, 10% glycerol, pH 8.0
Molecular Mass : The recombinant human BCL6/Trx fusion protein consisting of 309 amino acids and has a calculated molecular mass of 34.2 kDa. It migrates as an approximately 33 kDa band in SDS-PAGE under reducing conditions.
Purity : > 92 % as determined by SDS-PAGE
Stability : Samples are stable for up to twelve months from date of receipt at -70 centigrade
Storage : Store it under sterile conditions at -20 centigrade to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Protein length : Met1-Met150
Gene Name : BCL6 B-cell CLL/lymphoma 6 [ Homo sapiens ]
Official Symbol : BCL6
Synonyms : BCL5; LAZ3; BCL6A; ZNF51; ZBTB27; B-cell lymphoma 6 protein; B-cell lymphoma 5 protein; B-cell lymphoma 6 protein transcript; BCL-5; BCL-6; cys-his2 zinc finger transcription factor; lymphoma-associated zinc finger gene on chromosome 3; protein LAZ-3; zinc finger and BTB domain-containing protein 27; zinc finger protein 51; zinc finger transcription factor BCL6S
Gene ID : 604
mRNA Refseq : NM_001130845
Protein Refseq : NP_001124317
MIM : 109565
UniProt ID : P41182
Chromosome Location : 3q27
Pathway : B Cell Receptor Signaling Pathway, organism-specific biosystem; DNA damage response (only ATM dependent), organism-specific biosystem; FoxO family signaling, organism-specific biosystem
Function : RNA polymerase II regulatory region sequence-specific DNA binding; chromatin DNA binding; metal ion binding

Not For Human Consumption!

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Customer Reviews (3)

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04/21/2022

    Its stability and structural integrity make it an ideal candidate for studying protein structures at high resolution.

    09/22/2021

      I am delighted to highly recommend the BCL6 Protein for researchers seeking excellent performance in Western blotting (WB) experiments and protein electron microscopy structure analysis

      12/11/2016

        Its exceptional purity and integrity ensure clear and reliable bands, enabling accurate detection and quantification of target proteins.

        Q&As (5)

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        What are the current challenges in targeting BCL6 protein for therapeutic purposes? 02/21/2023

        Challenges include the need to develop specific and effective inhibitors of BCL6 function while minimizing off-target effects and ensuring tolerability in clinical settings.

        Are there any known genetic mutations or alterations in the BCL6 gene associated with disease susceptibility? 10/07/2022

        Yes, genetic mutations and translocations involving the BCL6 gene have been linked to the development of certain lymphomas and other hematological malignancies.

        What role does BCL6 protein play in the germinal center reaction? 06/13/2022

        BCL6 protein is crucial for the formation and maintenance of germinal centers, where it regulates the processes of somatic hypermutation and class-switch recombination in B cells.

        How might targeting BCL6 protein offer new therapeutic options for autoimmune diseases? 06/30/2021

        Targeting BCL6 protein could potentially offer new therapeutic options by modulating immune responses and suppressing the aberrant production of autoantibodies in autoimmune diseases.

        Can the assessment of BCL6 protein expression aid in the prognosis of lymphoma patients? 05/22/2017

        Yes, the assessment of BCL6 protein expression can provide valuable prognostic information, helping to predict patient outcomes and guide treatment strategies for lymphoma patients.

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