• Official Full Name

    baculoviral IAP repeat containing 3

  • Background

    This gene encodes a member of the IAP family of proteins that inhibit apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. The encoded protein inhibits apoptosis induced by serum deprivation but does not affect apoptosis resulting from exposure to menadione, a potent inducer of free radicals. It contains 3 baculovirus IAP repeats and a ring finger domain. Transcript variants encoding the same isoform have been identified.
  • Synonyms

    BIRC3; baculoviral IAP repeat containing 3; API2, baculoviral IAP repeat containing 3; baculoviral IAP repeat-containing protein 3; apoptosis inhibitor 2; c IAP2; cIAP2; hiap 1; inhibitor of apoptosis protein 1; MALT2; mammalian IAP homolog C; MIHC; RNF4;
    • Type:
    • Recombinant Proteins
    • Cell & Tissue Lysates
    • Protein Pre-coupled Magnetic Beads
    • Species :
    • Human
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Insect Cell
    • Mammalian Cell
    • Sf9 Insect Cell
    • Wheat Germ
    • Tag :
    • GST
    • GST|StrepII
    • His
    • His (Fc)
    • Avi
    • His|StrepII
    • Myc
    • DDK
    • N/A
    • N
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human BIRC3-319H Recombinant Human BIRC3 Protein, His-tagged E.coli N-His
    Human BIRC3-554H Recombinant Human BIRC3 Mammalian Cell His
    Human BIRC3-635H Active Recombinant Human BIRC3 Protein, GST-tagged, Active Insect Cell GST
    Human BIRC3-27246TH Recombinant Human BIRC3 Wheat Germ N/A
    Human BIRC3-2910H Recombinant Human BIRC3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human BIRC3-8450HCL Recombinant Human BIRC3 293 Cell Lysate HEK293 N/A
    Human BIRC3-2540H Recombinant Human BIRC3 protein, His-tagged E.coli His
    Human BIRC3-8451HCL Recombinant Human BIRC3 293 Cell Lysate HEK293 N/A
    Human BIRC3-2544H Recombinant Human BIRC3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Human BIRC3-190H Recombinant Human BIRC3, GST-tagged Sf9 Insect Cell GST
    Human BIRC3-2544H-B Recombinant Human BIRC3 Protein Pre-coupled Magnetic Beads HEK293
    Human BIRC3-69H Recombinant Human BIRC3 protein, GST/StrepII-tagged E.coli GST/StrepII
    Human BIRC3-70H Recombinant Human BIRC3 protein, His/StrepII-tagged E.coli His/StrepII
    • Involved Pathway
    • Protein Function
    • Interacting Protein
    • BIRC3 Related Research Area

    BIRC3 involved in several pathways and played different roles in them. We selected most pathways BIRC3 participated on our site, such as NF-kappa B signaling pathway, Ubiquitin mediated proteolysis, Apoptosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with BIRC3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    NF-kappa B signaling pathwayBIRC2;BTK;IL1R1;PLCG2;TNFRSF1A;LTA;BCL2A1;BCL2L1;GADD45B
    Ubiquitin mediated proteolysisMGRN1;UBE2IA;PRP19;ANAPC4;CUL1;ITCH;UBE2K;RBX1;UBE2G1B
    Focal adhesionAKT2;MYL10;ARHGAP5;FN1A;ITGA7;RAC1B;COL5A1;MYLK3;MYL12B
    NOD-like receptor signaling pathwayTRIP6;MAPK14B;MAPK3;SUGT1;RIPK2;CXCL2;TNFAIP3;PSTPIP1A;CASP1
    TNF signaling pathwayMAP3K7IP3;PIK3R1;MAGI2;IKBKB;FOS;MAPK11;PIK3R2;ITCH;TRAF5
    Pathways in cancerRALB;TP53;TRAF2;FGF6;LPAR3;XIAP;LPAR4;EGLN3;BIRC5
    Transcriptional misregulation in cancerTCF3;RXRB;LYL1;RARA;GOLPH3L;HMGA2;TAF15;SIX4;PTK2
    Small cell lung cancerCCND1;BCL2;XIAP;LAMB2;TP53;CKS2;TRAF2;PTEN;PIAS2

    BIRC3 has several biochemical functions, for example, cysteine-type endopeptidase inhibitor activity involved in apoptotic process, ligase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BIRC3 itself. We selected most functions BIRC3 had, and list some proteins which have the same functions with BIRC3. You can find most of the proteins on our site.

    Function Related Protein
    cysteine-type endopeptidase inhibitor activity involved in apoptotic processRPS6KA1;PRDX3;SERPINB9;NAIP1;SNCA;PRDX5;VIL1;BIRC8;BIRC7
    ligase activityHLTF;UBE1Y1;ATG10;LRSAM1;RTCD1;PRP19;RNF19A;ZNRF2B;UHRF1
    ubiquitin-protein transferase activityFBXL3;WDSUB1;MIB2;TRAF4A;UBE2G1;TRAF6;LNX2B;UBE2D2;UHRF1
    zinc ion bindingRNF130;ADAM10;TRIM23;MARCH2;COP1;RNF215;ZDHHC21;GRIN2B;AMZ2

    BIRC3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BIRC3 here. Most of them are supplied by our site. Hope this information will be useful for your research of BIRC3.


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