BIRC3 Protein


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Official Full Name baculoviral IAP repeat containing 3
Background This gene encodes a member of the IAP family of proteins that inhibit apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. The encoded protein inhibits apoptosis induced by serum deprivation but does not affect apoptosis resulting from exposure to menadione, a potent inducer of free radicals. It contains 3 baculovirus IAP repeats and a ring finger domain. Transcript variants encoding the same isoform have been identified.
Synonyms BIRC3; baculoviral IAP repeat containing 3; API2, baculoviral IAP repeat containing 3; baculoviral IAP repeat-containing protein 3; apoptosis inhibitor 2; c IAP2; cIAP2; hiap 1; inhibitor of apoptosis protein 1; MALT2; mammalian IAP homolog C; MIHC; RNF4
    • Species :
    • Human
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Insect Cell
    • Mammalian Cell
    • Sf9 Insect Cell
    • Wheat Germ
    • Tag :
    • GST
    • StrepII
    • His
    • Myc/DDK
    • N/A
    • N-His
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human BIRC3-2540H Recombinant Human BIRC3 protein, His-tagged E.coli His
    Human BIRC3-319H Recombinant Human BIRC3 Protein, His-tagged E.coli N-His
    Human BIRC3-190H Recombinant Human BIRC3, GST-tagged Sf9 Insect Cell GST
    Human BIRC3-27246TH Recombinant Human BIRC3 Wheat Germ N/A
    Human BIRC3-2910H Recombinant Human BIRC3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human BIRC3-554H Recombinant Human BIRC3 Mammalian Cell His
    Human BIRC3-635H Recombinant Human BIRC3 Protein, GST-tagged, Active Insect Cell GST
    Human BIRC3-69H Recombinant Human BIRC3 protein, GST/StrepII-tagged E.coli GST/StrepII
    Human BIRC3-70H Recombinant Human BIRC3 protein, His/StrepII-tagged E.coli His/StrepII
    Human BIRC3-8450HCL Recombinant Human BIRC3 293 Cell Lysate HEK293 N/A
    Human BIRC3-8451HCL Recombinant Human BIRC3 293 Cell Lysate HEK293 N/A

    BIRC3 involved in several pathways and played different roles in them. We selected most pathways BIRC3 participated on our site, such as NF-kappa B signaling pathway, Ubiquitin mediated proteolysis, Apoptosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with BIRC3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    NF-kappa B signaling pathway RELA; PIDD1; IKBKB; TRAF1; PLCG2; TRAF5; LCK; CCL4L2; RIPK1; LAT
    Ubiquitin mediated proteolysis RHOBTB2A; UBE2QL1; COP1; CDC23; UBE2G1A; UBE4B; UBA1; DET1; FZR1; UBE2E3
    Focal adhesion TNC; VEGFB; RAF1; ITGA3B; FYNA; COL4A1; TLN2A; SPP1; RAC3B; THBS3A
    NOD-like receptor signaling pathway CASPA; RELA; HSP90AA1.2; CCL2; TAB2; TRIP6; HSP90B1; IL18; NFKBIA; BIRC2
    TNF signaling pathway MAPK13; CASP8; PIK3CD; PTGS2; TNF; TRAF5; ICAM1; IKBKG; CXCL5; MAP2K3
    Toxoplasmosis LAMA5; IKBKB; BAD; TNF; HLA-DOB; PIK3R3; LDLR; H2-AB1; MYD88; IRAK1
    Pathways in cancer FOXO1; BDKRB1; PGF; TGFBR2; ITGAV; FGF5; BDKRB2; PRKCB; ROCK1; TCEB2
    Transcriptional misregulation in cancer BCL2A1; ZEB1; KLF3; SIX1; RUNX1; CD14; SS18; PTK2; PROM1; GRIA3
    Small cell lung cancer PTEN; PIK3CB; CYCS; COL4A1; PIK3R2; AKT2; ITGA2B; BIRC7; NFKB1; CASP9

    BIRC3 has several biochemical functions, for example, cysteine-type endopeptidase inhibitor activity involved in apoptotic process, ligase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BIRC3 itself. We selected most functions BIRC3 had, and list some proteins which have the same functions with BIRC3. You can find most of the proteins on our site.

    Function Related Protein
    cysteine-type endopeptidase inhibitor activity involved in apoptotic process GAS6; CD27; SNCA; IGF1RA; IGF1RB; RPS6KA3; BIRC8; RPS6KA1; C1QL4L; ARRB1
    ligase activity DTX4; ADSSL; RTCD1; MDM2; RNF40; RNF115; UBE2NB; TTLL9; RNF123; HECTD3
    protein binding SPINK7; LDHA; SAE1; EPN2; CD86; ARF1; MLLT3; CD6; BARHL2; PKMYT1
    ubiquitin-protein transferase activity MARCH4; UBE2E2; RBCK1; TSPAN17; MIB2; BIRC7; UBR1; BIRC2; BTR22; LMO7
    zinc ion binding MATR3L; SRSF7A; NR5A2; ADAMDEC1; ZMIZ1; CA15A; MDM4; TAB2; DNMT1; RYBPB

    BIRC3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BIRC3 here. Most of them are supplied by our site. Hope this information will be useful for your research of BIRC3.


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