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  • Official Full Name

    baculoviral IAP repeat containing 3

  • Overview

    This gene encodes a member of the IAP family of proteins that inhibit apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. The encoded protein inhibits apoptosis induced by serum deprivation but does not affect apoptosis resulting from exposure to menadione, a potent inducer of free radicals. It contains 3 baculovirus IAP repeats and a ring finger domain. Transcript variants encoding the same isoform have been identified.
  • Synonyms

    BIRC3; baculoviral IAP repeat containing 3; API2, baculoviral IAP repeat containing 3; baculoviral IAP repeat-containing protein 3; apoptosis inhibitor 2; c IAP2; cIAP2; hiap 1; inhibitor of apoptosis protein 1; MALT2; mammalian IAP homolog C; MIHC; RNF4;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Insect Cell
  • Mammalian Cell
  • Sf9 Insect Cell
  • Wheat Germ
  • GST
  • GST|StrepII
  • His
  • His (Fc)
  • Avi
  • His|StrepII
  • Myc
  • DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human BIRC3-635H Active Recombinant Human BIRC3 Protein, GST-tagged Insect Cell GST
Human BIRC3-554H Recombinant Human BIRC3 Mammalian Cell His
Human BIRC3-27246TH Recombinant Human BIRC3 Wheat Germ N/A 604 amino acids
Human BIRC3-190H Recombinant Human BIRC3, GST-tagged Sf9 Insect Cell GST
Human BIRC3-69H Recombinant Human BIRC3 protein, GST/StrepII-tagged E.coli GST/StrepII 244-349
Human BIRC3-70H Recombinant Human BIRC3 protein, His/StrepII-tagged E.coli His/StrepII 244-349
Human BIRC3-8450HCL Recombinant Human BIRC3 293 Cell Lysate HEK293 N/A
Human BIRC3-8451HCL Recombinant Human BIRC3 293 Cell Lysate HEK293 N/A
Human BIRC3-319H Recombinant Human BIRC3 Protein, His-tagged E.coli N-His Lys439-Gln529
Human BIRC3-2910H Recombinant Human BIRC3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human BIRC3-36HF Recombinant Full Length Human BIRC3 Protein In Vitro Cell Free System 604 amino acids
Human BIRC3-2540H Recombinant Human BIRC3 protein, His-tagged E.coli His 78-169 aa
Human BIRC3-2544H Recombinant Human BIRC3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human BIRC3-2544H-B Recombinant Human BIRC3 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • BIRC3 Related Research Area

BIRC3 involved in several pathways and played different roles in them. We selected most pathways BIRC3 participated on our site, such as NF-kappa B signaling pathway, Ubiquitin mediated proteolysis, Apoptosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with BIRC3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
NF-kappa B signaling pathwayPLAU;CCL4L1;BLNK;TRAF1;CCL13;IRAK4;LBP;BCL2L1;CD14
Ubiquitin mediated proteolysisTRIM32;CDC23;XIAP;ANAPC1;UBE2S;SIAH2L;SMURF1;NEDD4;UBE3A
NOD-like receptor signaling pathwayTNFAIP3;RIPK2;MAPK11;TNF;HSP90AA1.2;NFKBIAB;NFKB1;BIRC3;HSP90AB1
TNF signaling pathwayPIK3R5;TRAF1;IKBKB;Ccl12;CXCL2;IL15;VEGFC;TRAF5;PIK3CA
ToxoplasmosisHLA-DQB1;MAPK10;IRGM;PPIF;STAT3;ITGB1;NFKBIA;Toxoplasma Gondii Profilin Family Protein;HSPA6
Transcriptional misregulation in cancerPAX7;SIX1;PAX3;Pdgfa&Pdgfb;KDM6A;TSPAN7;PBX3;H3F3B;MMP3
Small cell lung cancerTRAF1;RB1;LAMA4;TRAF2;BIRC8;CCND1;CKS2;AKT1;PIK3CD

BIRC3 has several biochemical functions, for example, cysteine-type endopeptidase inhibitor activity involved in apoptotic process, ligase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BIRC3 itself. We selected most functions BIRC3 had, and list some proteins which have the same functions with BIRC3. You can find most of the proteins on our site.

Function Related Protein
cysteine-type endopeptidase inhibitor activity involved in apoptotic processBIRC2;CD27;BIRC8;TNFSF14;PRDX3;BIRC7;GAS6;LEF1;VIL1
protein bindingMEF2A;ARL13B;NCAM1A;C1orf38;C6orf130;CST9L;TIMM50;SCGB2A2;LONP1
ubiquitin-protein transferase activityFBXO9;TTC3;TRAF4A;ZNRF1;UBE2D2;CBLB;TRIM62;BIRC2;FBXL3
zinc ion bindingTCEA2;CA15A;KDM2B;LHX2B;DTX3;PHF13;WTIP;FBXO11;RNFT1

BIRC3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BIRC3 here. Most of them are supplied by our site. Hope this information will be useful for your research of BIRC3.


  • Q&As
  • Reviews

Q&As (7)

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What is the primary role of BIRC3 in apoptosis regulation? 10/29/2022

BIRC3 (cIAP2) inhibits apoptosis, regulating cell death.

How does BIRC3 interact with other proteins in apoptosis pathways? 08/29/2022

BIRC3 interacts with proteins in apoptosis pathways, influencing cell survival.

What role does BIRC3 play in immune responses? 07/12/2022

BIRC3 plays a role in immune response, especially in inflammation.

How do genetic variations in BIRC3 affect disease susceptibility? 10/24/2020

Genetic changes in BIRC3 affect susceptibility to cancers and immune disorders.

How does BIRC3 contribute to cell survival? 10/12/2019

It promotes cell survival by blocking apoptosis signals.

What is the impact of altered BIRC3 activity on inflammatory conditions? 12/30/2017

Altered BIRC3 activity impacts inflammatory disease progression.

What potential therapeutic applications arise from targeting BIRC3 in inflammatory and cancerous diseases? 07/07/2017

Targeting BIRC3 could treat diseases with abnormal apoptosis, like cancer and inflammation.

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