birc3

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birc3

Official Full Name baculoviral IAP repeat containing 3
Background This gene encodes a member of the IAP family of proteins that inhibit apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. The encoded protein inhibits apoptosis induced by serum deprivation but does not affect apoptosis resulting from exposure to menadione, a potent inducer of free radicals. It contains 3 baculovirus IAP repeats and a ring finger domain. Transcript variants encoding the same isoform have been identified.
Synonyms BIRC3; baculoviral IAP repeat containing 3; API2, baculoviral IAP repeat containing 3; baculoviral IAP repeat-containing protein 3; apoptosis inhibitor 2; c IAP2; cIAP2; hiap 1; inhibitor of apoptosis protein 1; MALT2; mammalian IAP homolog C; MIHC; RNF4
    • Species :
    • Human
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Insect Cell
    • Mammalian Cell
    • Sf9 Insect Cell
    • Wheat Germ
    • Tag :
    • GST
    • StrepII
    • His
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human BIRC3-190H Recombinant Human BIRC3, GST-tagged Sf9 Insect Cell GST
    Human BIRC3-27246TH Recombinant Human BIRC3 Wheat Germ N/A
    Human BIRC3-2910H Recombinant Human BIRC3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human BIRC3-554H Recombinant Human BIRC3 Mammalian Cell His
    Human BIRC3-635H Recombinant Human BIRC3 Protein, GST-tagged, Active Insect Cell GST
    Human BIRC3-69H Recombinant Human BIRC3 protein, GST/StrepII-tagged E.coli GST/StrepII
    Human BIRC3-70H Recombinant Human BIRC3 protein, His/StrepII-tagged E.coli His/StrepII
    Human BIRC3-8450HCL Recombinant Human BIRC3 293 Cell Lysate HEK293 N/A
    Human BIRC3-8451HCL Recombinant Human BIRC3 293 Cell Lysate HEK293 N/A

    birc3 involved in several pathways and played different roles in them. We selected most pathways birc3 participated on our site, such as NF-kappa B signaling pathway, Ubiquitin mediated proteolysis, Apoptosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with birc3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    NF-kappa B signaling pathway PTGS2; IRAK4; PRKCB; TNFSF11; GADD45B; TNF; PRKCQ; BCL2A1; PLCG2; DDX58
    Ubiquitin mediated proteolysis HUWE1; CDC16; MDM2; UBE2KA; UBE2G1B; ITCHA; UBE2K; UBE2I; UBE2G2; UBE4B
    Apoptosis TNFRSF10C; PPP3R1; CLSPN; PKP1; PRKAR1B; IRF1B; IRAK1; PIK3R5; PIK3CB; DCC
    Focal adhesion VAV2; MAPK3; MYL9A; COL2A1; MAP2K1; PPP1CA; ITGA9; RAF1; COL27A1; PARVA
    NOD-like receptor signaling pathway NLRC4; Ccl12; MAP3K7IP3; IKBKB; PYDC1; NAIP1; MAPK8; TNFAIP3; BIRC3; HSP90AA1.1
    TNF signaling pathway TRAF1; CREB3L1; RIPK1; MAP3K7IP3; TNFRSF1A; DNM1L; MAP2K1; PIK3R2; PIK3R5; Ccl12
    Toxoplasmosis LAMA3; BCL2L1; HLA-DQB1; MAPK3; LAMA4; MAP2K6; TGFB1; MAP3K7; HLA-DQA2; Toxoplasma Gondii Major Surface Antigen P30
    Pathways in cancer MAPK3; RELA; PTGS2; PDGFRB; FLT3; PRKACA; CSF3R; GNA12; Fgf15; PIK3CG
    Transcriptional misregulation in cancer PRCC; ZEB1; ATM; EWSR1; TMPRSS2; ZBTB16; PAX3; TAF15; GOLPH3L; FOXO1
    Small cell lung cancer TP53; BIRC2; APAF1; TRAF1; NFKBIA; PTEN; AKT2; LAMB4; CYCS; TRP53

    birc3 has several biochemical functions, for example, cysteine-type endopeptidase inhibitor activity involved in apoptotic process, ligase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by birc3 itself. We selected most functions birc3 had, and list some proteins which have the same functions with birc3. You can find most of the proteins on our site.

    Function Related Protein
    cysteine-type endopeptidase inhibitor activity involved in apoptotic process PRDX5; TNFSF14; LEF1; GAS6; TFAP2B; RPS6KA3; ARRB1; BIRC7; CD27; BIRC3
    ligase activity SIAH1A; IRF2BP1; MDM2; CBLB; RNF144AB; ZNRF1; LIG4; MKRN1; MARCH1; PDZRN3
    protein binding GRIK3; EIF4EBP3L; CCDC36; NR2C1; PEX1; EXOC3; FAM207A; CNEP1R1; EYA1; FCGR1A
    ubiquitin-protein transferase activity CBLL1; RNF220; TSPAN17; CDC23; TRIM24; TRAF4; TRIM9; CNOT4; TRAF3; MARCH8
    zinc ion binding TXNDC17; RABGGTA; CHORDC1; DTX3; PRKCBB; BSPRY; MYT1LA; NPEPPS; S100A9; BTR12

    birc3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with birc3 here. Most of them are supplied by our site. Hope this information will be useful for your research of birc3.

    TRAF2; RIPK2; RIPK4; RIPK1; RIPK3; UBA1

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