BIRC3
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Official Full Name
baculoviral IAP repeat containing 3
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Background
This gene encodes a member of the IAP family of proteins that inhibit apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. The encoded protein inhibits apoptosis induced by serum deprivation but does not affect apoptosis resulting from exposure to menadione, a potent inducer of free radicals. It contains 3 baculovirus IAP repeats and a ring finger domain. Transcript variants encoding the same isoform have been identified. -
Synonyms
BIRC3; baculoviral IAP repeat containing 3; API2, baculoviral IAP repeat containing 3; baculoviral IAP repeat-containing protein 3; apoptosis inhibitor 2; c IAP2; cIAP2; hiap 1; inhibitor of apoptosis protein 1; MALT2; mammalian IAP homolog C; MIHC; RNF4;
- Involved Pathway
- Protein Function
- Interacting Protein
- BIRC3 Related Research Area
BIRC3 involved in several pathways and played different roles in them. We selected most pathways BIRC3 participated on our site, such as NF-kappa B signaling pathway, Ubiquitin mediated proteolysis, Apoptosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with BIRC3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| NF-kappa B signaling pathway | BIRC2;BTK;IL1R1;PLCG2;TNFRSF1A;LTA;BCL2A1;BCL2L1;GADD45B |
| Ubiquitin mediated proteolysis | MGRN1;UBE2IA;PRP19;ANAPC4;CUL1;ITCH;UBE2K;RBX1;UBE2G1B |
| Apoptosis | PRKAR1B;MAP3K14;BAXA;IRAK2;AIFM1;NFKBIAA;IL1R1;OCLN;TRADD |
| Focal adhesion | AKT2;MYL10;ARHGAP5;FN1A;ITGA7;RAC1B;COL5A1;MYLK3;MYL12B |
| NOD-like receptor signaling pathway | TRIP6;MAPK14B;MAPK3;SUGT1;RIPK2;CXCL2;TNFAIP3;PSTPIP1A;CASP1 |
| TNF signaling pathway | MAP3K7IP3;PIK3R1;MAGI2;IKBKB;FOS;MAPK11;PIK3R2;ITCH;TRAF5 |
| Toxoplasmosis | TAB2;XIAP;LAMB4;IL12A;HSPA8;ITGB1;IRGM1;IFNGR1;HLA-DMB |
| Pathways in cancer | RALB;TP53;TRAF2;FGF6;LPAR3;XIAP;LPAR4;EGLN3;BIRC5 |
| Transcriptional misregulation in cancer | TCF3;RXRB;LYL1;RARA;GOLPH3L;HMGA2;TAF15;SIX4;PTK2 |
| Small cell lung cancer | CCND1;BCL2;XIAP;LAMB2;TP53;CKS2;TRAF2;PTEN;PIAS2 |
BIRC3 has several biochemical functions, for example, cysteine-type endopeptidase inhibitor activity involved in apoptotic process, ligase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BIRC3 itself. We selected most functions BIRC3 had, and list some proteins which have the same functions with BIRC3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cysteine-type endopeptidase inhibitor activity involved in apoptotic process | RPS6KA1;PRDX3;SERPINB9;NAIP1;SNCA;PRDX5;VIL1;BIRC8;BIRC7 |
| ligase activity | HLTF;UBE1Y1;ATG10;LRSAM1;RTCD1;PRP19;RNF19A;ZNRF2B;UHRF1 |
| protein binding | KIF21A;CTLA2B;DTX3L;IFT46;CGGBP1;CSNK1D;CHRNB2;ITK;PTPN6 |
| ubiquitin-protein transferase activity | FBXL3;WDSUB1;MIB2;TRAF4A;UBE2G1;TRAF6;LNX2B;UBE2D2;UHRF1 |
| zinc ion binding | RNF130;ADAM10;TRIM23;MARCH2;COP1;RNF215;ZDHHC21;GRIN2B;AMZ2 |
BIRC3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BIRC3 here. Most of them are supplied by our site. Hope this information will be useful for your research of BIRC3.
TRAF2; RIPK2; RIPK4; RIPK1; RIPK3; UBA1
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