BRD4 Protein


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Official Full Name bromodomain containing 4
Background The protein encoded by this gene is homologous to the murine protein MCAP, which associates with chromosomes during mitosis, and to the human RING3 protein, a serine/threonine kinase. Each of these proteins contains two bromodomains, a conserved sequence motif which may be involved in chromatin targeting. This gene has been implicated as the chromosome 19 target of translocation t(15;19)(q13;p13.1), which defines an upper respiratory tract carcinoma in young people. Two alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008]
Synonyms BRD4; bromodomain containing 4; CAP; MCAP; HUNK1; HUNKI; bromodomain-containing protein 4; bromodomain-containing 4; chromosome-associated protein;
    • Species :
    • Chicken
    • Human
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Insect Cell
    • Mammalian Cell
    • Tag :
    • GST
    • His
    • Flag
    • His-Flag
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human BRD4-158H Recombinant Human BRD4, GST-tagged E.coli GST
    Human BRD4-1904H Recombinant Human BRD4, GST-tagged E.coli GST
    Human BRD4-1918H Recombinant Human BRD4, His-tagged HEK293 His
    Human BRD4-1921H Recombinant Human BRD4, His-tagged E.coli His
    Human BRD4-36H Recombinant Human BRD4, His&FLAG-tagged E.coli His/Flag
    Human BRD4-5928H Recombinant Human BRD4 protein, His-tagged Insect Cell His
    Human BRD4-902H Recombinant Human BRD4 Mammalian Cell His
    Chicken BRD4-3229C Recombinant Chicken BRD4 Mammalian Cell His
    Zebrafish BRD4-6275Z Recombinant Zebrafish BRD4 Mammalian Cell His
    Human BRD4-179HCL Recombinant Human BRD4 cell lysate N/A
    Human BRD4-37H Recombinant Human BRD4(Glu49-Glu460) Protein, N-10*His-Flag-tagged E.coli His-Flag
    Human BRD4-3907H Recombinant Human BRD4 protein, His-tagged E.coli His
    Kit-1642 HEK 293 BRD4(1) Bromodomain Assay Kit N/A
    Kit-1696 BRD4 (BD1) Inhibitor Screening Assay Kit N/A
    Kit-1697 BRD4 (BD1) TR-FRET Assay Kit N/A
    Kit-1698 BRD4 (BD1+BD2) TR-FRET Assay Kit N/A
    Kit-1699 BRD4 (BD2) Inhibitor Screening Assay Kit N/A
    Kit-1930 BRD4 bromodomain 1 TR-FRET Assay Kit N/A
    Kit-1931 BRD4 bromodomain 2 TR-FRET Assay Kit N/A
    Kit-1932 BRD4 bromodomains 1 and 2 TR-FRET Assay Kit N/A

    BRD4 involved in several pathways and played different roles in them. We selected most pathways BRD4 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with BRD4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein

    BRD4 has several biochemical functions, for example, DNA binding, chromatin binding, lysine-acetylated histone binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BRD4 itself. We selected most functions BRD4 had, and list some proteins which have the same functions with BRD4. You can find most of the proteins on our site.

    Function Related Protein
    DNA binding FOXF2A; SRFB; EVE1; PCBP3; ZNF576.2; TERT; UPF1; KIF4; PPP1R10; PRM3
    chromatin binding TAL1; TOX2; GPR30; LDB2A; FEZF2; HMGB1; TWIST2; SKI; SOX9; MSH6
    lysine-acetylated histone binding PSME4; BAZ2A; BRD3; BRD7; TAF1L; BRDT; TRIM24; SMARCA4; PHIP; CARM1
    p53 binding ZNF385D; TRP63; TRIM29; HSPD1; ANKRD1; NUAK1; TRP53; KDM1A; TP53BP1; TAF3
    protein binding CDX1; RARA; CSRNP2; PLSCR3; CERK; AP2S1; KLK8; FNBP1; HIRA; PPIL2

    BRD4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BRD4 here. Most of them are supplied by our site. Hope this information will be useful for your research of BRD4.

    RELA; JMJD6; E2

    Gao, FJ; Yang, YY; et al. BRAD4 plays a critical role in germinal center response by regulating Bcl-6 and NF-kappa B activation. CELLULAR IMMUNOLOGY 294:1-8(2015).
    Dragoescu, E; French, C; et al. NUT Midline Carcinoma Presenting With Bilateral Ovarian Metastases: A Case Report. INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY 34:136-142(2015).

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