Recombinant Human BRD4, GST-tagged

Cat.No. : BRD4-1904H
Product Overview : Recombinant Human BRD4 (65-459 aa) was expressed in E. coli.
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  • Gene Information
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Description : The acetylation of histone lysine residues plays a crucial role in the epigenetic regulation of gene transcription. A bromodomain is a protein domain that recognizes acetylated lysine residues such as those on the N-terminal tails of histones. This recognition is often a prerequisite for protein-histone association and chromatin remodeling. These domains function in the linking of protein complexes to acetylated nucleosomes, thereby controlling chromatin structure and gene expression. Thus, bromodomains serve as "readers" of histone acetylation marks regulating the transcription of target promoters. The BET family of proteins, defined by tandem Bromodomains and an Extra Terminal domain, include BRD2, BRD3, BRD4, and BRDT. The BET proteins play a key role in many cellular processes, including inflammatory gene expression, mitosis, and viral/host interactions. The isolated individual or tandem bromodomains of BRD2 and BRD4 have been shown to bind acetylated histone tails, serving to couple histone acetylation marks to the transcriptional regulation of target promoters. Small molecule inhibitors of these interactions hold promise as useful therapeutics for human disease. This protein can be used for the study of bromodomain binding assays, screening inhibitors, and selectivity profiling.
Source : E. coli
Species : Human
Tag : GST
Appearance : Liquid
Form : 50 mM Tris, pH 7.5, containing 500 mM sodium chloride, 5% glycerol, and 5 mM β-mercaptoethanol.
Molecular Mass : 71.2 kDa (65-459 aa + GST Tag)
Protein length : 65-459 aa
Purity : ≥90% by SDS - PAGE
Usage : For Research Use Only! Not For Use in Humans.
Storage : Store at -80°C. Avoid repeated freeze and thaw cycles. Stable for 6 months.
Gene Name : BRD4 bromodomain containing 4 [ Homo sapiens (human) ]
Official Symbol : BRD4
Synonyms : BRD4; bromodomain containing 4; CAP; MCAP; HUNK1; HUNKI; bromodomain-containing protein 4; bromodomain-containing 4; chromosome-associated protein; EC 3.1.1.31
Gene ID : 23476
mRNA Refseq : NM_014299
Protein Refseq : NP_055114
MIM : 608749
UniProt ID : O60885
Chromosome Location : 19p13.1
Function : DNA binding; protein binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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