Active Recombinant Human BRD4 (BD1) Protein (49-170), N-His tagged

Cat.No. : BRD4-35H
Product Overview : Active Recombinant human BRD4 (BD1) (49-170) was expressed in E. coli cells using an N-terminal His tag.
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Description : Bromodomain-containing protein 4 (BRD4) is a member of the bromodomain and extra-terminal domain (BET) protein family. BRD4 contains two tandem bromodomains: BD1 and BD2. BRD4 (BD1) functions as an epigenetic reader – recognizing and interpreting histone acetylation marks to recruit transcriptional machinery and chromatin remodeling complexes. BRD4 (BD1) is involved in the regulation of cell cycle progression, with its overexpression promoting cell proliferation and survival. Furthermore, it has been implicated in the development and progression of cancer as it regulates the expression of oncogenes and tumor suppressor genes.
Source : E. coli
Species : Human
Tag : N-His
Bio-activity : 2,908 ng/min/mg
Molecular Mass : Observed MW: ~15 kDa
Calculated MW: ~14.7 kDa
Protein Length : 49-170
Purity : > 90%
Stability : One year at –70 centigrade from date of shipment.
Storage : Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Concentration : 0.1 μg/μL
Storage Buffer : Recombinant protein stored in 50mM sodium phosphate, pH 7.0, 300mM NaCl, 150mM imidazole, 0.25mM DTT, 25% glycerol.
Shipping : Dry ice
SDS-PAGE: The binding activity of BRD4 (BD1) was determined to be 2,908 ng/min/mg towards acetylated peptide substrate as per the activity assay protocol.
Gene Name : BRD4 bromodomain containing 4 [ Homo sapiens (human) ]
Official Symbol : BRD4
Synonyms : BRD4; bromodomain containing 4; bromodomain-containing protein 4; CAP; chromosome associated protein; HUNK1; HUNKI; MCAP; bromodomain-containing 4; chromosome-associated protein;
Gene ID : 23476
mRNA Refseq : NM_014299
Protein Refseq : NP_055114
MIM : 608749
UniProt ID : O60885

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.


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