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Official Full Name calcium channel, voltage-dependent, alpha 2/delta subunit 1
Background This gene encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.
Synonyms CACNA2D1; calcium channel, voltage-dependent, alpha 2/delta subunit 1; CACNA2, CACNL2A, MHS3; voltage-dependent calcium channel subunit alpha-2/delta-1; calcium channel, L type, alpha 2 polypeptide; voltage-gated calcium channel subunit alpha-2/delta-1; d
    • Species :
    • Chicken
    • Human
    • Mouse
    • Source :
    • E.coli
    • Mammalian Cell
    • Yeast
    • Tag :
    • GST
    • His
    • SUMO
    • His-SUMO
    • Trx
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CACNA2D1-089H Recombinant Human CACNA2D1 protein, His-SUMO-tagged E.coli His-SUMO
    Human CACNA2D1-2619H Recombinant Human CACNA2D1 protein, His-SUMO-tagged E.coli His-SUMO
    Human CACNA2D1-3729H Recombinant Human CACNA2D1 protein, GST-tagged E.coli GST
    Human CACNA2D1-161H Recombinant Human CACNA2D1 Mammalian Cell His
    Human CACNA2D1-2301H Recombinant Human CACNA2D1 Protein (577-717 aa), His-tagged Yeast His
    Human CACNA2D1-2391H Recombinant Human CACNA2D1 Protein (528-668 aa), His-SUMO-tagged E.coli His/SUMO
    Human CACNA2D1-29H Recombinant Human CACNA2D1 protein, Trx-His-SUMO-tagged E.coli Trx/His/SUMO
    Mouse CACNA2D1-2615M Recombinant Mouse CACNA2D1 Protein Mammalian Cell His
    Chicken CACNA2D1-4079C Recombinant Chicken CACNA2D1 Mammalian Cell His

    CACNA2D1 involved in several pathways and played different roles in them. We selected most pathways CACNA2D1 participated on our site, such as MAPK signaling pathway, Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, which may be useful for your reference. Also, other proteins which involved in the same pathway with CACNA2D1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    MAPK signaling pathway AKT2; ARRB2A; RPS6KA3B; FGF4; PPM1B; MAP2K2A; PPP5C; NFKB2; PTPRR; ARRB1
    Cardiac muscle contraction CACNG1A; ATP2A2; COX6A2; ATP1B2; COX7A2L; ATP1A1A.1; TNNC1B; CACNA1SA; COX8C; ATP1A1
    Adrenergic signaling in cardiomyocytes MYH15; CAMK2G1; ACTC1; ATP1A1B; ATP1B3A; CACNG1; GNA15.4; PIK3R5; PPP2R3C; SCN1BA
    Oxytocin signaling pathway CALM2; CACNB1; CALM1; CACNA2D2; PLCB2; MEF2C; TRPM2; GNAI2; GUCY1A3; CACNB2
    Hypertrophic cardiomyopathy (HCM) ITGA3; MYH7; SGCG; ACE; EMD; ITGA8; CACNA2D1; CACNG4; ITGB1; PRKAG2
    Arrhythmogenic right ventricular cardiomyopathy (ARVC) CACNG8; ACTB; DMD; TCF7L2; ITGA1; SGCA; ITGB5; CACNB1; CTNNA1; LEF1
    Dilated cardiomyopathy CACNG4; ITGA1; PRKACB; CACNB4; CACNG8; MYL2; IGF1; TNNI3; ITGB4; TNNC1

    CACNA2D1 has several biochemical functions, for example, calcium channel regulator activity, metal ion binding, voltage-gated calcium channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CACNA2D1 itself. We selected most functions CACNA2D1 had, and list some proteins which have the same functions with CACNA2D1. You can find most of the proteins on our site.

    Function Related Protein
    calcium channel regulator activity NPY2R; SGK3; GRM2; SGK2; CACNA2D1; CACNA2D1A; SGK2B; STIM1A; TSPAN13B; STIM1
    metal ion binding DCST1; ADIPOR2; EYA4; ZNF804A; SLX1B; FAH; PLA2G4D; ZNHIT3; TP73; ZNF222
    voltage-gated calcium channel activity CACNB2A; NCS1; CACNG7A; CACNG2B; CACNG3; CACNB2; CACNA1BA; CACNB2B; CACNG2; CACNG1A
    contributes_to voltage-gated calcium channel activity CACNB4; CACNB3; CACNA2D1

    CACNA2D1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CACNA2D1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CACNA2D1.

    Baz2b; MYH7B; Calu; Itgb1; Plk2; HNRNPU; Ccdc77; CNOT2

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