Recombinant Human CACNA2D1 protein, Trx-His-SUMO-tagged CACNA2D1-29H

Cat.No.:	CACNA2D1-29H
Product Overview:	Recombinant Human CACNA2D1, fused with Trx-His-SUMO tag, was expressed in E. coli.
Description:	This gene encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of acomplex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.
Source:	E.coli
Species:	Human
Tag:	Trx-His-SUMO
Form:	20mM Hepes, 50mM NaCl, 1‰ Tween20, pH8.0.
Molecular Mass:	148kDa(including fusion tag)
Protein length:	1315aa(including fusion tag)
Applications:	WB, ELISA, IP, antibody production, protein array
Storage:	Store at -80°C and avoid repeated freeze-thaw cycles.

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Gene Name:	CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 [ Homo sapiens ]
Official Symbol:	CACNA2D1
Synonyms:	CACNA2D1; CACNA2; CCHL2A; CACNL2A;
Gene ID:	781
mRNA Refseq:	NM_000722
Protein Refseq:	NP_000713
MIM:	114204
UniProt ID:	P54289
Chromosome Location:	Arrhythmogenic right ventricular cardiomyopathy (ARVC), organism-specific biosystem; Arrhythmogenic right ventricular cardiomyopathy (ARVC), conserved biosystem; Cardiac muscle contraction, organism-specific biosystem; Cardiac muscle contraction, conserved biosystem; Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels, organism-specific biosystem; Dilated cardiomyopathy, organism-specific biosystem; Dilated cardiomyopathy, conserved biosystem;
Pathway:	metal ion binding; contributes_to voltage-gated calcium channel activity; voltage-gated ion channel activity;