"CACNA2D1" Related Products

Recombinant Human CACNA2D1 protein, Trx-His-SUMO-tagged

Cat.No.: CACNA2D1-29H
Product Overview: Recombinant Human CACNA2D1, fused with Trx-His-SUMO tag, was expressed in E. coli.
Description: This gene encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of acomplex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.
Source: E.coli
Species: Human
Tag: Trx-His-SUMO
Form: 20mM Hepes, 50mM NaCl, 1‰ Tween20, pH8.0.
Molecular Mass: 148kDa(including fusion tag)
Protein length: 1315aa(including fusion tag)
Applications: WB, ELISA, IP, antibody production, protein array
Storage: Store at -80°C and avoid repeated freeze-thaw cycles.
Gene Name: CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 [ Homo sapiens ]
Official Symbol: CACNA2D1
Gene ID: 781
mRNA Refseq: NM_000722
Protein Refseq: NP_000713
MIM: 114204
UniProt ID: P54289
Chromosome Location: Arrhythmogenic right ventricular cardiomyopathy (ARVC), organism-specific biosystem; Arrhythmogenic right ventricular cardiomyopathy (ARVC), conserved biosystem; Cardiac muscle contraction, organism-specific biosystem; Cardiac muscle contraction, conserved biosystem; Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels, organism-specific biosystem; Dilated cardiomyopathy, organism-specific biosystem; Dilated cardiomyopathy, conserved biosystem;
Pathway: metal ion binding; contributes_to voltage-gated calcium channel activity; voltage-gated ion channel activity;

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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