Recombinant Human CACNA2D1 protein, Trx-His-SUMO-tagged


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Recombinant Human CACNA2D1 protein, Trx-His-SUMO-tagged

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Cat.No. : CACNA2D1-29H
Product Overview : Recombinant Human CACNA2D1, fused with Trx-His-SUMO tag, was expressed in E. coli.
Description : This gene encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of acomplex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.
Source : E.coli
Species : Human
Tag : Trx-His-SUMO
Form : 20mM Hepes, 50mM NaCl, 1‰ Tween20, pH8.0.
Molecular Mass : 148kDa(including fusion tag)
Protein length : 1315aa(including fusion tag)
Applications : WB, ELISA, IP, antibody production, protein array
Storage : Store at -80°C and avoid repeated freeze-thaw cycles.
Gene Name : CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 [ Homo sapiens ]
Official Symbol : CACNA2D1
Gene ID : 781
mRNA Refseq : NM_000722
Protein Refseq : NP_000713
MIM : 114204
UniProt ID : P54289
Chromosome Location : Arrhythmogenic right ventricular cardiomyopathy (ARVC), organism-specific biosystem; Arrhythmogenic right ventricular cardiomyopathy (ARVC), conserved biosystem; Cardiac muscle contraction, organism-specific biosystem; Cardiac muscle contraction, conserved biosystem; Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels, organism-specific biosystem; Dilated cardiomyopathy, organism-specific biosystem; Dilated cardiomyopathy, conserved biosystem;
Pathway : metal ion binding; contributes_to voltage-gated calcium channel activity; voltage-gated ion channel activity;
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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