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CCL1

  • Official Full Name

    chemokine (C-C motif) ligand 1

  • Overview

    Chemokine (C-X-C motif) ligand 1 (CXCL1) is a small cytokine belonging to the CXC chemokine family that was previously called GRO1 oncogene, GROα, KC, Neutrophil-activating protein 3 (NAP-3) and melanoma growth stimulating activity, alpha (MSGA-α). In humans, this protein is encoded by the CXCL1 gene.
  • Synonyms

    CCL1; chemokine (C-C motif) ligand 1; C-C motif chemokine 1; P500; TCA3; CCR8 ligand; SIS-epsilon; T-cell activation protein 3; small inducible cytokine A1; small-inducible cytokine A1; I-309; Scya1; Tca-3; BF534335; Ccl1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Hamster
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • CHO
  • E.coli
  • HEK293
  • Human Cell
  • Human Cells
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Biotin
  • DYKDDDDK
  • GST
  • hFc
  • His
  • Avi
  • His (Fc)
  • His|GST
  • N/A
  • N
  • MBP
  • C
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CCL1-29H Recombinant Human Chemokine (C-C Motif) Ligand 1 E.coli N/A
Human CCL1-19H Recombinant Human CCL1, hFc-tagged HEK293 hFc Lys 24-Lys 96
Human CCL1-1532H Recombinant Human CCL1 protein, His & GST-tagged E.coli His/GST Lys24~Lys96 (Accession # P22362)
Human CCL1-605H Recombinant Human CCL1 protein E.coli N/A 74
Human CCL1-0604H Recombinant Human CCL1 Protein, GST-Tagged Wheat Germ GST
Human CCL1-168H Recombinant Human CCL1, His-tagged E.coli His
Human CCL1-3060HCL Recombinant Human CCL1 cell lysate Human Cell N/A
Human CCL1-30H Recombinant Human CCL1(Lys24-Lys96) Protein, None-tagged E.coli N/A
Human CCL1-214H Recombinant Human CCL1 Protein, DYKDDDDK-tagged Human Cells DYKDDDDK
Human CCL1-69H Recombinant Human CCL1 Protein E.coli 73 amino acid
Human CCL1-77H Recombinant Human CCL1 Protein, Biotin-tagged E.coli Biotin
Human CCL1-266C Active Recombinant Human CCL1 Protein (73 aa) CHO 73
Human CCL1-2918HF Recombinant Full Length Human CCL1 Protein, GST-tagged In Vitro Cell Free System GST 96 amino acids
Human CCL1-0883H Recombinant Human CCL1 Protein (Lys24-Lys96), N-GST tagged E.coli N-GST Lys24-Lys96
Human CCL1-383C Active Recombinant Human CCL1 Protein (74 aa) E.coli 74
Human CCL1-1856H Active Recombinant Human CCL1 protein, His & Avi-tagged, Biotinylated HEK293 His & Avi Lys 24 - Lys 96
Human CCL1-1168H Recombinant Human CCL1 protein(24-96aa), MBP&His-Avi-tagged, Biotinylated E.coli N-MBP&C-His-Avi 24-96aa
Human CCL1-111C Active Recombinant Human CCL1 Protein (74 aa) E.coli 74
Mouse Ccl1-621M Recombinant Mouse Ccl1 protein(Lys24-Cys92), hFc-tagged HEK293 N-hFc Lys24-Cys92
Mouse Ccl1-126M Recombinant Mouse Chemokine (C-C Motif) Ligand 1 Mammalian cells N/A
Mouse CCL1-1690MCL Recombinant Mouse CCL1 cell lysate Human Cell N/A
Mouse Ccl1-10525M Recombinant Mouse Ccl1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Ccl1-639M Recombinant Mouse Ccl1 Protein, His-tagged E.coli N-His Lys24-Cys92
Mouse Ccl1-2027M Active Recombinant Mouse Ccl1 Protein HEK293 Lys24-Cys92
Mouse Ccl1-10525M-B Recombinant Mouse Ccl1 Protein Pre-coupled Magnetic Beads HEK293
Rat Ccl1-640R Recombinant Rat Ccl1 Protein, His-tagged E.coli N-His Lys24-Cys92
Hamster Ccl1-638H Recombinant Hamster Ccl1 Protein, His&GST-tagged E.coli N-His&GST Lys24-Cys91
Rhesus Macaque CCL1-678R Recombinant Rhesus monkey CCL1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque CCL1-506R-B Recombinant Rhesus Macaque CCL1 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque CCL1-506R Recombinant Rhesus Macaque CCL1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Chicken CCL1-6340C Recombinant Chicken CCL1 Mammalian Cell His
  • Background
  • Quality Guarantee
  • Case Study
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

What is ccl1 protein?

CCL1, also known as chemokine (C-C motif) ligand 1, is a small cytokine belonging to the CC chemokine family that was previously called I-309. It is produced by activated T cells and has been identified as a potent chemoattractant for monocytes, T lymphocytes, and eosinophils. The chemokine CCL1 is also involved in immunoregulatory and inflammatory processes.

The discovery of CCL1 protein dates back to the earlier years of chemokine research in the 1990s. This small protein of about 8-14 kDa was initially termed I-309 due to its immune cell activity. The protein was re-designated later on as CCL1 under a systematic nomenclature following chemokine characterizations.

CCL1 protein consists of 74 amino acids, with four cysteine residues involved in the formation of two disulfide bonds that connect Cys11 to Cys50 and Cys12 to Cys34. The structure of the monomeric chemokine accommodates an extended N-terminus, a three-stranded beta sheet, and a C-terminal alpha helix, which are commonly found in most members of the chemokine family.

The structural consensus of CCL1 is juxtaposed by its unique receptor specificity. Among the 19 human CC chemokines, CCL1 is the only one that binds the receptor CCR8 selectively. This specific relationship between ligand and receptor prevents the interaction with other cell types expressing alternative receptors, making CCL1 signaling more precise and narrow in scope compared to many other chemokine signals.

CCL1 protein plays a significant role in T cell activation and inflammatory processes. Its abnormal signaling has been implicated in various pathologies like allergies, autoimmunity, and cancer, and it's often seen as a potential therapeutic target.

What is the function of ccl1 protein?

Chemoattraction - It acts as a chemoattractant for immune cells like T lymphocytes, monocytes, dendritic cells and eosinophils by binding to the CCR8 receptor.

Cell recruitment - CCL1 recruits these leukocytes to sites of inflammation, infection or injury by inducing directed migration/chemotaxis.

T cell trafficking - It plays an important role in trafficking T lymphocytes to lymph nodes and sites of antigen presentation.

Inflammation - CCL1 contributes to inflammatory responses by stimulating migration and infiltration of immune cells into tissues.

CCL1 related signaling pathway

CCR8 signaling pathway: Binding of CCL1 to its receptor CCR8 on immune cells activates downstream G-protein coupled signaling cascades.

JAK-STAT signaling pathway: CCL1 stimulation leads to phosphorylation of JAK kinases and STAT proteins, regulating gene expression of pro-inflammatory cytokines.

MAPK signaling pathway: CCL1 activates MAPKs like ERK, JNK and p38 kinases involved in cell migration, proliferation and inflammatory responses.

NF-κB signaling pathway: CCL1 stimulation activates NF-κB, a major pro-inflammatory transcription factor inducing chemokines and adhesion molecules.

CCL1 Related Diseases

Cancer: Upregulated in several cancers like breast, prostate and lung cancers. Promotes proliferation and metastasis via leukocyte recruitment.

Asthma: Increased levels in asthmatic airways contribute to eosinophilic inflammation.

Autoimmune diseases: Higher CCL1 levels seen in multiple sclerosis, rheumatoid arthritis, inflammatory bowel disease.

Atopic dermatitis: Plays a role in allergic skin inflammation by recruiting T cells and eosinophils.

Biomedical Application of CCL1 Protein

Cancer immunotherapy: CCL1 inhibitors may block tumor-promoting inflammation and metastasis.

Anti-angiogenic therapy: Targeting CCL1's pro-angiogenic role offers new avenues to cut off blood supply to tumors.

Anti-inflammatory drug development: Agents modulating CCL1 signaling could help treat inflammatory/autoimmune conditions.

High Purity

SDS-PAGE CCL1-605H.jpg

Fig1. SDS-PAGE (Cat. No.: CCL1-605H)

TMAs of breast cancer and healthy breast tissue were analyzed.jpg

(Benjamin Kuehnemuth, 2018)

Fig2. TMAs of breast cancer and healthy breast tissue were analyzed for the number of positive cells/mm2. For statistical analysis the Mann-Whitney-U-Test was used

Binding studies of the T48 aptamer to hCCL1.jpg

(Martin L. Marro, 2006)

Fig3.Binding studies of the T48 aptamer to hCCL1. Nitrocellulose binding studies of the T48 aptamer (▴, solid line) and a random control aptamer (•, dashed line).

CCL1 involved in several pathways and played different roles in them. We selected most pathways CCL1 participated on our site, such as Cytokine-cytokine receptor interaction, Chemokine signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CCL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cytokine-cytokine receptor interactionGM2002;IL2RGA;CD27;TNFSF18;IL15RA;Il23a; Il12b;Ifnlr1;TGFBR1A;TNFSF11
Chemokine signaling pathwayHRAS;PIK3R2;CCL11;GSK3B;ADRBK1;GM10591;CCL28;FOXO3;GM13304

CCL1 has several biochemical functions, for example, CCR chemokine receptor binding, chemokine activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CCL1 itself. We selected most functions CCL1 had, and list some proteins which have the same functions with CCL1. You can find most of the proteins on our site.

Function Related Protein
CCR chemokine receptor bindingCCL19;CCL20;CCL33.3;CCL19A.1;CCL24;XCL1;CCL18;CCL38A.5;XCL2
chemokine activityCCL3;CCL13;CCL20;XCL1;CCL19A.1;CCL24;CCL39.1;CXCL11.8;CXCL5

CCL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CCL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CCL1.

Gene Family

Chemokines Cytokines

Research Area

Related articles

Metcalf, TU; Baxter, VK; et al. Recruitment and Retention of B Cells in the Central Nervous System in Response to Alphavirus Encephalomyelitis. JOURNAL OF VIROLOGY 87:2420-2429(2013).
Birkhauser, FD; Koya, RC; et al. Dendritic Cell-Based Immunotherapy in Prevention and Treatment of Renal Cell Carcinoma: Efficacy, Safety, and Activity of Ad-GM.CAIX in Immunocompetent Mouse Models. JOURNAL OF IMMUNOTHERAPY 36:102-111(2013).
  • Q&As
  • Reviews

Q&As (5)

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How does CCL1 contribute to the pathogenesis of inflammatory conditions? 04/30/2021

CCL1 promotes the recruitment of immune cells to inflamed tissues, exacerbating inflammation and contributing to the pathogenesis of various inflammatory conditions.

Are there any ongoing clinical trials targeting CCL1 for therapeutic intervention? 06/26/2020

Several clinical trials are exploring the therapeutic potential of targeting CCL1 in autoimmune diseases and inflammatory disorders to modulate immune responses.

How does CCL1 interact with other immune modulators, and what implications does this have for drug development? 03/24/2020

CCL1 interacts with various immune modulators, and understanding these interactions is crucial for developing targeted therapies that can modulate the immune response more effectively.

In what ways does CCL1 participate in the regulation of immune responses? 05/25/2018

CCL1 regulates immune responses by influencing the migration and activation of specific immune cells, modulating the overall immune system's activity.

How does CCL1 influence the migration of specific immune cell types, and how is this mechanism exploited in clinical applications? 05/16/2016

CCL1 selectively influences the migration of specific immune cell types, and understanding this mechanism is essential for developing therapies that target specific immune responses in various diseases.

Customer Reviews (3)

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Reviews
11/14/2022

    Its exceptional purity and integrity ensure clear and reliable bands, enabling accurate detection and quantification of target proteins.

    12/03/2019

      Its stability and structural integrity make it an ideal candidate for studying protein structures at high resolution.

      11/11/2019

        I am delighted to highly recommend the aroE Protein for researchers seeking excellent performance in Western blotting (WB) experiments and protein electron microscopy structure analysis

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