Recombinant Human Chemokine (C-C Motif) Ligand 1

• Cat.No.: CCL1-29H
• Product Overview: Recombinant Human I-309 produced in E.Coli is a single,non-glycosylated, polypeptide chain containing 74 amino acids and having a molecular mass of 8504 Dalton. The I-309 is purified by proprietary chromatographic techniques.

Specification

• Cat. No.: CCL1-29H
• Description: Chemokine (C-C motif) ligand 1 (CCL1) is a small glycoprotein secreted by activated T cells that belongs to a family inflammatory cytokines known as chemokines. CCL1 attracts monocytes, NK cells, and immature B cells and dendritic cells by interacting with a cell surface chemokine receptor called CCR8. This chemokine resides in a large cluster of CC chemokines on human chromosome 17.
• Source: Escherichia Coli.
• Amino Acid Sequence: The sequence of the first five N-terminal amino acids was determined and was found to be Ser-Lys-Ser-Met-Gln.
• Physical Appearance: Sterile Filtered White lyophilized (freeze-dried) powder.
• Purity: Greater than 99.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
• Formulation: The protein was lyophilized with no additives.
• Solubility: It is recommended to reconstitute the lyophilized I-309 in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.
• Biological Activity: The Biological activity is calculated by its ability to chemoattract human T cells at 10.0-100.0 ng/ml.
• Storage: Lyophilized I-309 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CCL1 should be stored at 4℃between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
• Tag: Non

Gene Information

• Gene Name: CCL1 chemokine (C-C motif) ligand 1 [ Homo sapiens ]
• Synonyms: CCL1; chemokine (C-C motif) ligand 1; C-C motif chemokine 1; I-309; inflammatory cytokine I-309; P500; SISe; SCYA1; small inducible cytokine A1 (I-309, homologous to mouse Tca-3); Small-inducible cytokine A1; T lymphocyte-secreted protein I-309; TCA3
• Gene ID: 6346
• mRNA Refseq: NM_002981
• Protein Refseq: NP_002972
• MIM: 182281
• UniProt ID: P22362
• Chromosome Location: 17q12
• Pathway: Chemokine signaling pathway; Cytokine-cytokine receptor interaction
• Function: chemokine activity; protein binding

Reviews

11/14/2022

Its exceptional purity and integrity ensure clear and reliable bands, enabling accurate detection and quantification of target proteins.

12/03/2019

Its stability and structural integrity make it an ideal candidate for studying protein structures at high resolution.

11/11/2019

I am delighted to highly recommend the aroE Protein for researchers seeking excellent performance in Western blotting (WB) experiments and protein electron microscopy structure analysis

Q&As

How does CCL1 contribute to the pathogenesis of inflammatory conditions?

CCL1 promotes the recruitment of immune cells to inflamed tissues, exacerbating inflammation and contributing to the pathogenesis of various inflammatory conditions.

Are there any ongoing clinical trials targeting CCL1 for therapeutic intervention?

Several clinical trials are exploring the therapeutic potential of targeting CCL1 in autoimmune diseases and inflammatory disorders to modulate immune responses.

How does CCL1 interact with other immune modulators, and what implications does this have for drug development?

CCL1 interacts with various immune modulators, and understanding these interactions is crucial for developing targeted therapies that can modulate the immune response more effectively.

In what ways does CCL1 participate in the regulation of immune responses?

CCL1 regulates immune responses by influencing the migration and activation of specific immune cells, modulating the overall immune system's activity.

How does CCL1 influence the migration of specific immune cell types, and how is this mechanism exploited in clinical applications?

CCL1 selectively influences the migration of specific immune cell types, and understanding this mechanism is essential for developing therapies that target specific immune responses in various diseases.