CCL14
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Official Full Name
chemokine (C-C motif) ligand 14
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Background
This gene, chemokine (C-C motif) ligand 14, is one of several CC cytokine genes clustered on 17q11.2. The CC cytokines are secreted proteins characterized by two adjacent cysteines. The cytokine encoded by this gene induces changes in intracellular calcium concentration and enzyme release in monocytes. Multiple transcript variants encoding different isoforms have been found for this gene. Read-through transcripts are also expressed that include exons from the upstream cytokine gene, chemokine (C-C motif) ligand 15, and are represented as GeneID: 348249. -
Synonyms
CCL14; SCYA14; HCC-1; HCC-3; NCC-2; SCYL2; CKb1; MCIF; Hemofiltrate CC Chemokine 1;
- Involved Pathway
- Protein Function
- Interacting Protein
- CCL14 Related Gene Family
- CCL14 Related Research Area
CCL14 involved in several pathways and played different roles in them. We selected most pathways CCL14 participated on our site, such as Cytokine-cytokine receptor interaction, Chemokine signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CCL14 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cytokine-cytokine receptor interaction | CXCL9;IL1RAP;PDGFAB;AMH;TNFSF14;CCR1L1;VEGFB;IL15;IL6ST |
| Chemokine signaling pathway | DOCK2;CCR3;CXCL9;PIK3R5;WASL;CCR5;PTK2B;RAF1;GM2506 |
CCL14 has several biochemical functions, for example, CCR chemokine receptor binding, chemokine activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CCL14 itself. We selected most functions CCL14 had, and list some proteins which have the same functions with CCL14. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| CCR chemokine receptor binding | CCL26;CCL15;CCL13;CCL19B;CCL38A.5;CCL19;CCL19A.2;CCL8;CCL17 |
| chemokine activity | CXCL3;CCL20;CCL26;XCL2;CCL25;CXCL5;CCL3L1;CXCL2;CCL35.1 |
CCL14 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CCL14 here. Most of them are supplied by our site. Hope this information will be useful for your research of CCL14.
ARRB1; PIK3R1; AKT2; ligB; anmK
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