ccl16
Share
  • Official Full Name
  • chemokine (C-C motif) ligand 16
  • Background
  • This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for lymphocytes and monocytes but not for neutrophils. This cytokine also shows a potent myelosuppressive activity and suppresses proliferation of myeloid progenitor cells. The expression of this gene is upregulated by IL-10.
  • Synonyms
  • CCL16; chemokine (C-C motif) ligand 16; SCYA16, small inducible cytokine subfamily A (Cys Cys), member 16; C-C motif chemokine 16; CKb12; HCC 4; LCC 1; LEC; LMC; Mtn 1; NCC 4; SCYL4; CCL16_HUMAN; Chemokine CC-4; Chemokine LEC; HCC-4; HCC4; IL-10-inducible chemokine; IL10 inducible chemokine; ILINCK; LCC-1; LCC1; Liver CC chemokine 1 precursor; Liver expressed chemokine; Liver-expressed chemokine; Lymphocyte and monocyte chemoattractant; Monotactin 1; Monotactin-1; MTN-1; Mtn1; NCC-4; NCC4; New CC chemokine 4; SCYA16; Small inducible cytokine A16 precursor; Small inducible cytokine subfamily A (Cys Cys) member 16; Small-inducible cytokine A16; OTTHUMP00000163951; liver CC chemokine-1; small indu
Cat.#:CCL16-0613HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CCL16 Protein, GST-Tagged
+Inquiry
Cat.#:CCL16-112HTag:
Source (Host):Species:Human
Product nameHuman CCL16
+Inquiry
Cat.#:CCL16-1528HTag:His/GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CCL16 protein, His & GST-tagged
+Inquiry
Cat.#:CCL16-242HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CCL16, His-tagged
+Inquiry
Cat.#:CCL16-296HTag:Strep II
Source (Host):HEK293Species:Human
Product nameRecombinant Human CCL16, StrepII-tagged
+Inquiry
Cat.#:CCL16-29941THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CCL16
+Inquiry
Cat.#:CCL16-352HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human CCL16, HIgG1 Fc-tagged, mutant
+Inquiry
Cat.#:CCL16-353HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human CCL16, MIgG2a Fc-tagged
+Inquiry
Cat.#:CCL16-354HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human CCL16,HIgG1 Fc-tagged
+Inquiry
Cat.#:CCL16-07HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Chemokine (C-C Motif) Ligand 16
+Inquiry
Cat.#:CCL16-7730HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human CCL16 293 Cell Lysate
+Inquiry

Involved Pathway

CCL16 involved in several pathways and played different roles in them. We selected most pathways CCL16 participated on our site, such as Cytokine-cytokine receptor interaction, Chemokine signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CCL16 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cytokine-cytokine receptor interaction
CCL28; CCL7; IFNA8; BMPR1BA; IL9R; TNFRSF13C; TSLP; BMPR2A; CCL20; IL7R
Chemokine signaling pathway
GNG12; CXCL16; SRC; CCL5; XCR1; CCR1; RAF1; CCL11; AKT1; VAV2

Protein Function

CCL16 has several biochemical functions, for example, CCR chemokine receptor binding, chemoattractant activity, chemokine activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CCL16 itself. We selected most functions CCL16 had, and list some proteins which have the same functions with CCL16. You can find most of the proteins on our site.
Function
Related Protein
Function CCR chemokine receptor binding
Related Protein CCL3L1; CCL16; CCL35.1; CCL34A.4; CCL19; CCL44; CCL25B; CCL38A.5; CCL33.3; CCL19A.1
Function chemoattractant activity
Related Protein CCL15; FGF7; FGF10; FIGF; VHL; FGF8; NTF3; CCL16; BMP4; VEGFC
Function chemokine activity
Related Protein CCL34A.3; CCL7; CXCL6; Ccl12; CCL6; CCL44; CXCL3; CXCL19; CXCL32B.1; CCL19A.1

CCL16 Related Articles

Mauri, G; Chiodoni, C; et al. Ultrasound-guided intra-tumor injection of combined immunotherapy cures mice from orthotopic prostate cancer. CANCER IMMUNOLOGY IMMUNOTHERAPY 62:1811-1819(2013).
He, DM; Li, MS; et al. Expression Pattern of Serum Cytokines in Hepatitis B Virus Infected Patients with Persistently Normal Alanine Aminotransferase Levels. JOURNAL OF CLINICAL IMMUNOLOGY 33:1240-1249(2013).

CCL16 Related Gene Family

Chemokines Cytokines