CCL16

  • Official Full Name

    chemokine (C-C motif) ligand 16

  • Overview

    This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for lymphocytes and monocytes but not for neutrophils. This cytokine also shows a potent myelosuppressive activity and suppresses proliferation of myeloid progenitor cells. The expression of this gene is upregulated by IL-10.
  • Synonyms

    CCL16; chemokine (C-C motif) ligand 16; SCYA16, small inducible cytokine subfamily A (Cys Cys), member 16; C-C motif chemokine 16; CKb12; HCC 4; LCC 1; LEC; LMC; Mtn 1; NCC 4; SCYL4; CCL16_HUMAN; Chemokine CC-4; Chemokine LEC; HCC-4; HCC4; IL-10-inducible chemokine; IL10 inducible chemokine; ILINCK; LCC-1; LCC1; Liver CC chemokine 1 precursor; Liver expressed chemokine; Liver-expressed chemokine; Lymphocyte and monocyte chemoattractant; Monotactin 1; Monotactin-1; MTN-1; Mtn1; NCC-4; NCC4; New CC chemokine 4; SCYA16; Small inducible cytokine A16 precursor; Small inducible cytokine subfamily A (Cys Cys) member 16; Small-inducible cytokine A16; OTTHUMP00000163951; liver CC chemokine-1; small indu;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Human
  • CHO
  • E.coli
  • HEK293
  • Human Cell
  • Human Cells
  • Wheat Germ
  • Yeast
  • Fc
  • GST
  • His
  • His|GST
  • HA
  • SUMO
  • N/A
  • N
  • Strep II
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CCL16-352H Active Recombinant Human CCL16, HIgG1 Fc-tagged, mutant CHO Fc
Human CCL16-353H Active Recombinant Human CCL16, MIgG2a Fc-tagged CHO Fc
Human CCL16-112H Active Human CCL16 N/A
Human CCL16-354H Active Recombinant Human CCL16,HIgG1 Fc-tagged CHO Fc
Human CCL16-29941TH Recombinant Human CCL16 E.coli N/A
Human CCL16-296H Recombinant Human CCL16, StrepII-tagged Human Cell Strep II
Human CCL16-0613H Recombinant Human CCL16 Protein, GST-Tagged Wheat Germ GST
Human CCL16-07H Recombinant Human CCL16 protein E.coli N/A
Human CCL16-1528H Recombinant Human CCL16 protein, His & GST-tagged E.coli His/GST
Human CCL16-242H Recombinant Human CCL16 protein, His-tagged E.coli His
Human CCL16-7730HCL Recombinant Human CCL16 293 Cell Lysate HEK293 N/A
Human CCL16-113C Active Recombinant Human CCL16 Protein (97 aa) E.coli
Human CCL16-0614H Recombinant Human CCL16 protein, His-tagged Yeast His
Human CCL16-2648H Recombinant Human CCL16 protein, His-SUMO-tagged E.coli His-SUMO
Human CCL16-151H Recombinant Human CCL16 Protein, His-tagged Human Cells His
Human CCL16-1014H Recombinant Human CCL16 Protein (Gln24-Gln120), N-GST tagged E.coli N-GST
Human CCL16-268C Active Recombinant Human CCL16 Protein (97 aa) CHO
Human CCL16-1498H Recombinant Human CCL16 protein, His-HA-tagged E.coli His-HA
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • CCL16 Related Articles
  • CCL16 Related Gene Family
  • CCL16 Related Research Area

CCL16 involved in several pathways and played different roles in them. We selected most pathways CCL16 participated on our site, such as Cytokine-cytokine receptor interaction, Chemokine signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CCL16 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cytokine-cytokine receptor interactionCSF2;CCL26;CCL19B;CCL25B;LTA;NT5C3;TGFB1;TNFRSF9;GM13305
Chemokine signaling pathwayPXN;CXCR1;WASL;PRKACG;Ccl21c;GNG4;HRAS;PIK3R1;ROCK2

CCL16 has several biochemical functions, for example, CCR chemokine receptor binding, chemoattractant activity, chemokine activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CCL16 itself. We selected most functions CCL16 had, and list some proteins which have the same functions with CCL16. You can find most of the proteins on our site.

Function Related Protein
CCR chemokine receptor bindingCCL8;CX3CL1;CCL1;CCL19A.1;CCL34B.4;CCL35.1;CCL19A.2;CCL18;CCL24
chemoattractant activityFIGF;CXCL12A;FGF8;CXCL12B;SAA3;FGF10;CCL15;NTF3;BMP4
chemokine activityCCL11;CXCL18B;CCL2;CXCL32B.1;CCL34B.9;CCL33.3;CXCL1;CCL34A.3;CCL23

CCL16 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CCL16 here. Most of them are supplied by our site. Hope this information will be useful for your research of CCL16.

Mauri, G; Chiodoni, C; et al. Ultrasound-guided intra-tumor injection of combined immunotherapy cures mice from orthotopic prostate cancer. CANCER IMMUNOLOGY IMMUNOTHERAPY 62:1811-1819(2013).
He, DM; Li, MS; et al. Expression Pattern of Serum Cytokines in Hepatitis B Virus Infected Patients with Persistently Normal Alanine Aminotransferase Levels. JOURNAL OF CLINICAL IMMUNOLOGY 33:1240-1249(2013).
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