- Human(17)
Active Human CCL16
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Cat.No. : | CCL16-112H Optional Service: Optional requirements on this protein |
Product Overview : | It is a synthetic Protein |
Description : | NCC-4 (also known as HCC-4) is a CC chemokine. It is a 97 amino acid protein. It exhibits less than 30% sequence identity to other CC chemokines. NCC-4 chemoattracts human monocytes and THP-1 cells. However it does not chemoattract resting lymphocytes or neutrophils. It has been found to supress proliferation of myeloid progenitor cells and induces calcium flux in THP-1 cells. This calcium flux can be desensitized by exposure to RANTES which suggests that NCC-4 and RANTES share the same receptor in THP-1 cells. |
Species : | Human |
Form : | Lyophilized |
Bio-activity : | Activity measured by the protein's ability to chemoattract THP-1 cells. ED50 for this activity is 0.5-3 μg/ml. |
Applications : | Activity Assay |
Storage : | Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles |
Reconstitution : | Recommended reconstitution in sterile phosphate buffered saline which contains at least 0.1% human or bovine serum albumin to prepare a stocksolution of no less than 20 μg/ml and vortex thoroughly. |
Gene Name : | CCL16 chemokine (C-C motif) ligand 16 [ Homo sapiens ] |
Official Symbol : | CCL16 |
Synonyms : | CCL16; chemokine (C-C motif) ligand 16; SCYA16, small inducible cytokine subfamily A (Cys Cys), member 16; C-C motif chemokine 16; CKb12; HCC 4; LCC 1; LEC; LMC; Mtn 1; NCC 4; SCYL4; monotactin-1; chemokine LEC; chemokine CC-4; new CC chemokine 4; liver CC chemokine-1; IL-10-inducible chemokine; liver-expressed chemokine; small-inducible cytokine A16; lymphocyte and monocyte chemoattractant; small inducible cytokine subfamily A (Cys-Cys), member 16; NCC4; HCC-4; LCC-1; Mtn-1; NCC-4; ILINCK; SCYA16; MGC117051; |
Gene ID : | 6360 |
mRNA Refseq : | NM_004590 |
Protein Refseq : | NP_004581 |
MIM : | 601394 |
UniProt ID : | O15467 |
Chromosome Location : | 17q11.2 |
Pathway : | Chemokine receptors bind chemokines, organism-specific biosystem; Chemokine signaling pathway, organism-specific biosystem; Chemokine signaling pathway, conserved biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; G alpha (i) signalling events, organism-specific biosystem; |
Function : | chemoattractant activity; chemokine activity; |
◆ Recombinant Protein
CCL16-113C | Recombinant Human CCL16 Protein (97 aa) | +Inquiry |
CCL16-0613H | Recombinant Human CCL16 Protein, GST-Tagged | +Inquiry |
CCL16-268C | Recombinant Human CCL16 Protein (97 aa) | +Inquiry |
CCL16-296H | Recombinant Human CCL16, StrepII-tagged | +Inquiry |
CCL16-352H | Active Recombinant Human CCL16, HIgG1 Fc-tagged, mutant | +Inquiry |
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◆ Lysates
CCL16-7730HCL | Recombinant Human CCL16 293 Cell Lysate | +Inquiry |
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CCL1CCL11Ccl12CCL13CCL14CCL15CCL16CCL17CCL18CCL19CCL2CCL20CCL21Ccl21cCCL22CCL23CCL24CCL25CCL26CCL27Ccl27aCCL28CCL3CCL3L1Ccl4CCL5Ccl6CCL7CCL8Ccl9CCL4L2Ccl21aCCL4L1CCL3L3Ccl21bCcl27b
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