CD207

  • Official Full Name

    CD207 molecule, langerin

  • Overview

    The protein encoded by this gene is expressed only in Langerhans cells which are immature dendritic cells of the epidermis and mucosa. It is localized in the Birbeck granules, organelles present in the cytoplasm of Langerhans cells and consisting of superimposed and zippered membranes. It is a C-type lectin with mannose binding specificity, and it has been proposed that mannose binding by this protein leads to internalization of antigen into Birbeck granules and providing access to a nonclassical antigen-processing pathway. Mutations in this gene result in Birbeck granules deficiency or loss of sugar binding activity. [provided by RefSeq, Aug 2010]
  • Synonyms

    CD207; CD207 molecule, langerin; CLEC4K; C-type lectin domain family 4 member K; CD207 antigen, langerin; Langerhans cell specific c-type lectin; C-type lectin domain family 4, member K;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chromatography Reagents
  • Human
  • Mouse
  • Rhesus Macaque
  • E.coli
  • HEK293
  • HEK293T
  • Human Cells
  • In Vitro Cell Free System
  • Insect Cell
  • Mamanlian cells
  • Mammalian cells
  • Wheat Germ
  • C
  • His
  • Fc
  • Flag
  • GST
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CD207-5607H Active Recombinant Human CD207 Molecule, Langerin, His-tagged Mammalian cells His
Human CD207-0745H Recombinant Human CD207 Protein Wheat Germ N/A
Human CD207-10924H Recombinant Human CD207, GST-tagged E.coli GST 1-328a.a.
Human CD207-0746H Recombinant Human CD207 Protein, GST-Tagged Wheat Germ GST
Human CD207-315H Recombinant Human CD207 protein, MYC/DDK-tagged HEK293 Myc/DDK
Human CD207-50H Recombinant Human CD207 protein, His-tagged Insect Cell His
Human CD207-7680HCL Recombinant Human CD207 293 Cell Lysate HEK293 N/A
Human CD207-3016HF Recombinant Full Length Human CD207 Protein, GST-tagged In Vitro Cell Free System GST 328 amino acids
Human CD207-3015HF Recombinant Full Length Human CD207 Protein In Vitro Cell Free System 377 amino acids
Human CD207-662H Recombinant Human CD207 Protein, His&GST-tagged E.coli N-His&GST Pro65-Pro328
Human CD207-151H Recombinant Human CD207 Protein, His-tagged Human Cells His
Human CD207-9932HFL Recombinant Full Length Human CD207 protein, Flag-tagged Mamanlian cells Flag
Human CD207-108H Recombinant Human CD207 Protein, His-tagged E.coli His
Human CD207-2629H Recombinant Human CD207 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human CD207-3416H Recombinant Human CD207 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human CD207-2629H-B Recombinant Human CD207 Protein Pre-coupled Magnetic Beads HEK293
Human CD207-4856M CD207 protein-coupled magnetic MicroBeads
Human CD207-1065H Recombinant Human CD207 Protein (Pro65-Pro328), N-GST tagged E.coli N-GST Pro65-Pro328
Human CD207-4789H Recombinant Human CD207 Protein (Pro65-Pro328), C-His tagged Mammalian cells C-His Pro65-Pro328
Mouse CD207-3051M Recombinant Mouse CD207 Protein, His-tagged HEK293 His 63-331aa
Mouse Cd207-2055M Recombinant Mouse Cd207 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse CD207-3921M CD207 protein-coupled magnetic MicroBeads
Mouse CD207-2336M Recombinant Mouse CD207 Protein (63-331 aa), His-tagged E.coli His 63-331 aa
Rhesus Macaque CD207-58R Recombinant Rhesus CD207 protein, Fc-tagged HEK293 Fc Pro65-Pro328
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

CD207 involved in several pathways and played different roles in them. We selected most pathways CD207 participated on our site, such as Adaptive Immune System, Antigen processing-Cross presentation, Class I MHC mediated antigen processing &amp, which may be useful for your reference. Also, other proteins which involved in the same pathway with CD207 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Adaptive Immune SystemCLTC;CTSH;FCGR1B;IGKV1-5;STUB1;RBCK1;AHCYL1;KLHL20;DYNC1I1
Antigen processing-Cross presentationSEC61B;FCGR1B;CTSL1;CYBB;CTSL2;CTSS;CYBA;CD207
Class I MHC mediated antigen processing &ampERAP2;UBR1;CD207;ASB17;ASB10;ASB18;SEC23A;FBXO17;FBXO44
presentationTRIM63;GAN;RNF14;ASB18;RBCK1;ASB13;FBXO3;UBE2L6;ASB7
Cross-presentation of soluble exogenous antigens (endosomes)CD207;FCGR1B
Immune SystemDZIP3;LGALS9;TLR6;BTR09;TRIM39;TXN;RNF41;TRIM6;NOD1

CD207 has several biochemical functions, for example, carbohydrate binding, mannose binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CD207 itself. We selected most functions CD207 had, and list some proteins which have the same functions with CD207. You can find most of the proteins on our site.

Function Related Protein
carbohydrate bindingCLEC5A;GALNT2;CLEC4D;CD302;ZG16;GALNT13;CD22;Siglece;SFTPD
mannose bindingBSG;CD209B;LMAN1;CD207;CLN5;CD209;CD209C;MRC1;CLEC4M

CD207 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CD207 here. Most of them are supplied by our site. Hope this information will be useful for your research of CD207.

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Research Area

Related articles

Vorobjova, T; Uibo, O; et al. Increased density of tolerogenic dendritic cells in the small bowel mucosa of celiac patients. WORLD JOURNAL OF GASTROENTEROLOGY 21:439-452(2015).
Stoitzner, P; Schaffenrath, S; et al. Human skin dendritic cells can be targeted in situ by intradermal injection of antibodies against lectin receptors. EXPERIMENTAL DERMATOLOGY 23:909-915(2014).
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