cd207

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cd207

Official Full Name CD207 molecule, langerin
Background The protein encoded by this gene is expressed only in Langerhans cells which are immature dendritic cells of the epidermis and mucosa. It is localized in the Birbeck granules, organelles present in the cytoplasm of Langerhans cells and consisting of superimposed and zippered membranes. It is a C-type lectin with mannose binding specificity, and it has been proposed that mannose binding by this protein leads to internalization of antigen into Birbeck granules and providing access to a nonclassical antigen-processing pathway. Mutations in this gene result in Birbeck granules deficiency or loss of sugar binding activity. [provided by RefSeq, Aug 2010]
Synonyms CD207; CD207 molecule, langerin; CLEC4K; C-type lectin domain family 4 member K; CD207 antigen, langerin; Langerhans cell specific c-type lectin; C-type lectin domain family 4, member K;
    • Species :
    • Human
    • Mouse
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293
    • Insect Cell
    • Mammalian Cell
    • NS0
    • Wheat Germ
    • Tag :
    • Fc
    • GST
    • His
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Mouse CD207-2336M Recombinant Mouse CD207 Protein (63-331 aa), His-tagged E.coli His
    Human CD207-0745H Recombinant Human CD207 Protein Wheat Germ N/A
    Human CD207-0746H Recombinant Human CD207 Protein, GST-Tagged Wheat Germ GST
    Human CD207-10924H Recombinant Human CD207, GST-tagged E.coli GST
    Human CD207-315H Recombinant Human CD207 protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human CD207-50H Recombinant Human CD207 protein, His-tagged Insect Cell His
    Human CD207-5607H Recombinant Human CD207 Molecule, Langerin, His-tagged NS0 His
    Human CD207-7680HCL Recombinant Human CD207 293 Cell Lysate HEK293 N/A
    Mouse CD207-3051M Recombinant Mouse CD207 Protein Mammalian Cell His
    Rhesus Macaque CD207-58R Recombinant Rhesus CD207 protein, Fc-tagged HEK293 Fc

    cd207 involved in several pathways and played different roles in them. We selected most pathways cd207 participated on our site, such as Adaptive Immune System, Antigen processing-Cross presentation, Class I MHC mediated antigen processing &amp, which may be useful for your reference. Also, other proteins which involved in the same pathway with cd207 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Adaptive Immune System CTSS; NRG2A; LRSAM1; KIF22; HBEGF; DYNC1LI2; RNF6; BLMH; RNF123; LILRB1
    Antigen processing-Cross presentation CTSS; CTSL2; CYBB; CYBA; CD207; CTSL1; SEC61B; FCGR1B
    Class I MHC mediated antigen processing &amp KLHL21; CTSS; RNF123; LRR1; ASB18; VPRBP; RNF25; CTSL1; GAN; RNF6
    presentation PJA2; VPRBP; SH3RF1; ASB3; CMTM2A; RNF138; UBR1; UBE2V1; NPEPPS; CD207
    Cross-presentation of soluble exogenous antigens (endosomes) FCGR1B; CD207
    Immune System IRF2; OSCAR; RNF216; LILRB3; CD226; TREX1; KIF4A; SAMHD1; SEC61B; IFIT14

    cd207 has several biochemical functions, for example, carbohydrate binding, mannose binding. Some of the functions are cooperated with other proteins, some of the functions could acted by cd207 itself. We selected most functions cd207 had, and list some proteins which have the same functions with cd207. You can find most of the proteins on our site.

    Function Related Protein
    carbohydrate binding SIGLEC7; ZG16; PKD1L3; LAYN; CD22; Cd24a; MAN2A2; CLEC6A; CLEC1B; CLEC9A
    mannose binding MBL1; CD209B; M6PR; CD209C; COLEC10; IGF2R; MANBA; Acr; CD209A; CD209

    cd207 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with cd207 here. Most of them are supplied by our site. Hope this information will be useful for your research of cd207.

    mnmG

    Vorobjova, T; Uibo, O; et al. Increased density of tolerogenic dendritic cells in the small bowel mucosa of celiac patients. WORLD JOURNAL OF GASTROENTEROLOGY 21:439-452(2015).
    Stoitzner, P; Schaffenrath, S; et al. Human skin dendritic cells can be targeted in situ by intradermal injection of antibodies against lectin receptors. EXPERIMENTAL DERMATOLOGY 23:909-915(2014).

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