Recombinant Human CD207 Protein

• Cat.No.: CD207-0745H
• Product Overview: Human CD207 full-length ORF (AAH22278.1) recombinant protein without tag.

Specification

• Description: The protein encoded by this gene is expressed only in Langerhans cells which are immature dendritic cells of the epidermis and mucosa. It is localized in the Birbeck granules, organelles present in the cytoplasm of Langerhans cells and consisting of superimposed and zippered membranes. It is a C-type lectin with mannose binding specificity, and it has been proposed that mannose binding by this protein leads to internalization of antigen into Birbeck granules and providing access to a nonclassical antigen-processing pathway. Mutations in this gene result in Birbeck granules deficiency or loss of sugar binding activity. [provided by RefSeq, Aug 2010]
• Source: Wheat Germ
• Species: Human
• Form: Liquid
• Molecular Mass: 36.7 kDa
• AA Sequence: MTVEKEAPDAHFTVDKQNISLWPRE PPPKSGPSLVPGKTPTVRAALICLT LVLVASVLLQAVLYPRFMGTISDVK TNVQLLKGRVDNISTLDSEIKKNSD GMEAAGVQIQMVNESLGYVRSQFLK LKTSVEKANAQIQILTRSWEEVSTL NAQIPELKSDLEKASALNTKIRALQ GSLENMSKLLKRQNDILQVVSQGWK YFKGNFYYFSLIPKTWYSAEQFCVS RNSHLTSVTSESEQEFLYKTAGGLI YWIGLTKAGMEGDWSWVDDTPFNKV QSARFWIPGEPNNAGNNEHCGNIKA PSLQAWNDAPCDKTFLFICKRPYVP SEP
• Applications: Antibody Production
  Functional Study
  Compound Screening
• Usage: Heating may cause protein aggregation. Please do not heat this product before electrophoresis.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 25 mM Tris-HCl of pH8.0 containing 2% glycerol.

Gene Information

• Gene Name: CD207 CD207 molecule, langerin [ Homo sapiens ]
• Official Symbol: CD207
• Synonyms: CD207; CD207 molecule, langerin; CD207 antigen, langerin; C-type lectin domain family 4 member K; CLEC4K; Langerin; Langerhans cell specific c-type lectin; C-type lectin domain family 4, member K
• Gene ID: 50489
• mRNA Refseq: NM_015717
• Protein Refseq: NP_056532
• MIM: 604862
• UniProt ID: Q9UJ71