CD209

  • Official Full Name

    CD209 molecule

  • Overview

    This gene encodes a transmembrane receptor and is often referred to as DC-SIGN because of its expression on the surface of dendritic cells and macrophages. The encoded protein is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino acid repeats in the neck domain of this protein are rare but have a significant impact on ligand binding ability. This gene is closely related in terms of both sequence and function to a neighboring gene (GeneID 10332; often referred to as L-SIGN). DC-SIGN and L-SIGN differ in their ligand-binding properties and distribution. Alternative splicing results in multiple variants.[provided by RefSeq, Feb 2009]
  • Synonyms

    CD209; CD209 molecule; CDSIGN; CLEC4L; DC-SIGN; DC-SIGN1; CD209 antigen; HIV gpl20-binding protein; C-type lectin domain family 4 member L; C-type lectin domain family 4, member L; dendritic cell-specific ICAM-3-grabbing non-integrin 1; dendritic cell-specific intracellular adhesion molecules (ICAM)-3 grabbing non-integrin;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops)
  • Human
  • Rhesus
  • Zebrafish
  • CHO
  • E.coli
  • E.coli expression system
  • HEK293
  • Human Cell
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • C
  • His
  • Fc
  • Flag
  • GST
  • hFc
  • His (Fc)
  • Avi
  • Strep,Flag
  • His|T7
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CD209-636H Active Recombinant Human CD209 protein, Fc-tagged Mammalian cells Fc Lys62-Ala404
Human CD209-635H Active Recombinant Human CD209 protein CHO N/A Gln59-Ala404
Human CD209-633H Recombinant Human CD209 protein, hFc-tagged HEK293 hFc Lys62-Ala404
Human CD209-634H Recombinant Human CD209 protein, Fc-tagged HEK293 Fc Lys62-Ala404
Human CD209-7173H Recombinant Human CD209 protein, His & T7-tagged E.coli His/T7 Glu70~Ala404 (Accession# Q9NNX6)
Human CD209-0747H Recombinant Human CD209 Protein Wheat Germ N/A
Human CD209-0748H Recombinant Human CD209 Protein, GST-Tagged Wheat Germ GST
Human CD209-2986HCL Recombinant Human CD209 cell lysate Human Cell N/A
Human CD209-643H Recombinant Human CD209 protein, His-tagged HEK293 His Gln 59 - Ala 404
Human CD209-3033HF Recombinant Full Length Human CD209 Protein In Vitro Cell Free System 359 amino acids
Human CD209-14H Recombinant Human CD209 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human CD209-0811H Recombinant Human CD209 Protein (M1-A404), His/Strep, Flag tagged E.coli His/Strep,Flag M1-A404
Human CD209-3034HF Recombinant Full Length Human CD209 Protein, GST-tagged In Vitro Cell Free System GST 404 amino acids
Human CD209-0919H Recombinant Human CD209 Protein (Glu70-Ala404), N-His tagged E.coli N-His Glu70-Ala404
Human CD209-14H-B Recombinant Human CD209 Protein Pre-coupled Magnetic Beads HEK293
Human CD209-4236H Recombinant Human CD209 Protein (Gln59-Ala404), N-Fc tagged Mammalian cells N-Fc Gln59-Ala404
Human CD209-057H Recombinant Human CD209 Protein, C-His-tagged E.coli C-His
Human CD209-0810H Recombinant Human CD209 Protein (M1-A404), Flag tagged E.coli Flag M1-A404
Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops) RFL7980CF Recombinant Full Length Chlorocebus Aethiops Cd209 Antigen(Cd209) Protein, His-Tagged E.coli expression system His Full Length (1-381)
Rhesus CD209-728R Recombinant Rhesus CD209 protein, Fc-tagged HEK293 Fc Lys62-Glu381
Rhesus CD209-727R Recombinant Rhesus CD209 protein, His-tagged HEK293 His Lys62-Glu381
Rhesus CD209-726R Recombinant Rhesus CD209 protein (Lys62-Glu381), His-tagged HEK293 His
Zebrafish CD209-7858Z Recombinant Zebrafish CD209 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

CD209 involved in several pathways and played different roles in them. We selected most pathways CD209 participated on our site, such as Phagosome, Tuberculosis, Measles, which may be useful for your reference. Also, other proteins which involved in the same pathway with CD209 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
PhagosomeITGAM;VAMP3;FCGR2C;THBS1;ITGB5;ITGAV;HLA-F;C1RA;RAB7A
TuberculosisPPP3CC;IFNA5;HLA-DRB3;IFNB1;TRADD;CALM4;SPHK2;RFXANK;HLA-DRA
MeaslesTP73;MAP3K7;CD209C;PIK3CD;HSPA2;STAT5A;TLR7;IFNG;IFNGR2

CD209 has several biochemical functions, for example, carbohydrate binding, mannose binding, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CD209 itself. We selected most functions CD209 had, and list some proteins which have the same functions with CD209. You can find most of the proteins on our site.

Function Related Protein
carbohydrate bindingLGALS9;PRPS1;WBSCR17;GALNT6;FREM1;LGALSL;CLEC1B;KLRB1;ASGR1
mannose bindingBSG;DPM1;CD209C;MAN2B1;CD209A;LMAN2L;MANBA;M6PR;LMAN1
metal ion bindingPVALB6;SNRNP48;ZFP82;SUZ12B;DDHD1;CYP46A1.3;RHOU;ZNF217;DNAJC21
peptide antigen bindingHLA-DRA;HLA-DPA1;HLA-A;MHC1ZKA;HLA-C;MHC1ZHA;HLA-DQA1;TUBB3;MHC1UXA2
protein bindingPINX1;NDEL1;OLA1;SMAD2;ETV6;SCRIB;ARL3;ESR1;NOLC1
virion bindingCD209;TSG101;HSP90B1;PVRL1;HIPK2;PTX3;CLEC4M;APCS;PPIA
virus receptor activityANPEP;CXADR;ICAM1;SLC1A5;TNFRSF4;DAG1;RPSA;ITGAV;PVR

CD209 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CD209 here. Most of them are supplied by our site. Hope this information will be useful for your research of CD209.

VAC14; q03463-pro_0000278734

Research Area

Related articles

Park, KT; Burnett, S; et al. Development and characterization of a monoclonal antibody specific for bovine CD209. VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY 163:216-220(2015).
Paul, M; Reljic, R; et al. Characterization of a plant-produced recombinant human secretory IgA with broad neutralizing activity against HIV. MABS 6:1585-1597(2014).
  • Q&As
  • Reviews

Q&As (5)

Ask a question
Can you discuss the role of CD209 in shaping adaptive immune responses and its impact on immunotherapy strategies? 01/23/2021

CD209 influences adaptive immune responses by modulating dendritic cell-T cell interactions. Understanding its role is critical for optimizing immunotherapy approaches, particularly in vaccine development.

How does CD209 participate in the recognition of glycosylated pathogens, and what are the implications for innate immunity? 11/14/2019

CD209 recognizes glycosylated patterns on pathogens, particularly through interactions with high-mannose structures. This recognition is crucial for initiating innate immune responses.

Can you elaborate on the genetic polymorphisms of CD209 and their association with susceptibility to infectious diseases? 06/09/2019

Genetic polymorphisms in CD209 have been associated with susceptibility to infectious diseases, including tuberculosis and HIV, suggesting a role in modulating host-pathogen interactions.

How does CD209 contribute to the formation of immunological synapses between dendritic cells and T cells, and what molecular events are involved? 02/09/2019

CD209 facilitates immunological synapse formation by mediating adhesion between dendritic cells and T cells. Molecular events involve interactions with ICAM-3 and other adhesion molecules.

How does CD209 contribute to immune responses, particularly in the context of antigen presentation? 06/02/2018

CD209 facilitates antigen capture by dendritic cells and modulates immune responses by mediating the interaction between dendritic cells and T cells during antigen presentation.

Customer Reviews (3)

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Reviews
01/07/2021

    The team promptly addressed my inquiries and provided valuable assistance in selecting the right recombined protein for our research.

    12/23/2019

      This product consistently delivers accurate results in our experiments.

      09/14/2018

        Quick service! The team provided efficient assistance in choosing the right protein for us.

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