cd209

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cd209

Official Full Name CD209 molecule
Background This gene encodes a transmembrane receptor and is often referred to as DC-SIGN because of its expression on the surface of dendritic cells and macrophages. The encoded protein is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino acid repeats in the neck domain of this protein are rare but have a significant impact on ligand binding ability. This gene is closely related in terms of both sequence and function to a neighboring gene (GeneID 10332; often referred to as L-SIGN). DC-SIGN and L-SIGN differ in their ligand-binding properties and distribution. Alternative splicing results in multiple variants.[provided by RefSeq, Feb 2009]
Synonyms CD209; CD209 molecule; CDSIGN; CLEC4L; DC-SIGN; DC-SIGN1; CD209 antigen; HIV gpl20-binding protein; C-type lectin domain family 4 member L; C-type lectin domain family 4, member L; dendritic cell-specific ICAM-3-grabbing non-integrin 1; dendritic cell-specific intracellular adhesion molecules (ICAM)-3 grabbing non-integrin;
    • Species :
    • Human
    • Rhesus
    • Zebrafish
    • Source :
    • CHO
    • E.coli
    • HEK293
    • Human Cell
    • Mammalian Cell
    • NS0
    • Wheat Germ
    • Tag :
    • Fc
    • GST
    • His
    • T7
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CD209-0747H Recombinant Human CD209 Protein Wheat Germ N/A
    Human CD209-0748H Recombinant Human CD209 Protein, GST-Tagged Wheat Germ GST
    Human CD209-2986HCL Recombinant Human CD209 cell lysate Human Cell N/A
    Human CD209-633H Recombinant Human CD209, Fc tagged Human Cell Fc
    Human CD209-634H Recombinant Human CD209 protein, Fc-tagged HEK293 Fc
    Human CD209-635H Recombinant Human CD209 protein CHO N/A
    Human CD209-636H Recombinant Human CD209 protein, Fc-tagged NS0 Fc
    Human CD209-7173H Recombinant Human CD209 protein, His & T7-tagged E.coli His/T7
    Rhesus CD209-727R Recombinant Rhesus CD209 protein, His-tagged HEK293 His
    Rhesus CD209-728R Recombinant Rhesus CD209 protein, Fc-tagged HEK293 Fc
    Zebrafish CD209-7858Z Recombinant Zebrafish CD209 Mammalian Cell His

    cd209 involved in several pathways and played different roles in them. We selected most pathways cd209 participated on our site, such as Phagosome, Tuberculosis, Measles, which may be useful for your reference. Also, other proteins which involved in the same pathway with cd209 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Phagosome DYNC1I1; CD209; BLA; Ctsl; ITGAM; ATP6V0D1; TUBB5; SEC22BB; NCF2; TUBA3A
    Tuberculosis RIPK2; IL18; IFNA17; FCGR2B; CAMK2B; CLEC7A; RFXAP; FCGR3B; TGFB1; MAPK1
    Measles RCHY1; CD209; HSPA8; IFNA16; Cd209g; DDX58; AKT2; TRP53; AKT1; IFNA2

    cd209 has several biochemical functions, for example, carbohydrate binding, mannose binding, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by cd209 itself. We selected most functions cd209 had, and list some proteins which have the same functions with cd209. You can find most of the proteins on our site.

    Function Related Protein
    carbohydrate binding REG1A; CNTN1; CLEC1A; CLEC6A; CLEC4E; GALM; CDIPT; LGALS9L1; FCN3; KLRB1
    mannose binding BSG; Acr; MBL2; DPM1; CLEC4M; MBL1; CD207; LMAN2; M6PR; MRC1
    metal ion binding Car8; POLI; TGFBR1; ZFP551; RNF128A; TDO2A; ZNF573; ZNF763; DTD1; PAPOLB
    peptide antigen binding H2-Q10; MR1; HLA-DRB4; MHC1ZE; HLA-DQB1; MHC1ZHA; MHC1ZFA; MHC1UDA; HLA-DPB1; TAP1
    protein binding F11; DBF4B; USP15; ZIC3; HPX; LRPPRC; EPHA7; EED; SEMA4D; BEND3
    virion binding PPIA; CLEC4M; CD209; PVRL1; HIPK2; PTX3; APCS; HSP90B1; TSG101
    virus receptor activity SLC20A2; CR2; ITGB3; CR1; ITGAV; LDLR; ITGB1; SLAMF1; ITGB5; CD209A

    cd209 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with cd209 here. Most of them are supplied by our site. Hope this information will be useful for your research of cd209.

    VAC14; q03463-pro_0000278734

    Park, KT; Burnett, S; et al. Development and characterization of a monoclonal antibody specific for bovine CD209. VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY 163:216-220(2015).
    Paul, M; Reljic, R; et al. Characterization of a plant-produced recombinant human secretory IgA with broad neutralizing activity against HIV. MABS 6:1585-1597(2014).

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