CFH Protein


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Official Full Name complement factor H
Background Factor H is a member of the regulators of complement activation family and is a complement control protein. It is a large (155 kilodaltons), soluble glycoprotein that circulates in human plasma (at a concentration of 500–800 micrograms per milliliter). Its principal function is to regulate the Alternative Pathway of the complement system, ensuring that the complement system is directed towards pathogens and does not damage host tissue. Factor H regulates complement activation on self cells by possessing both cofactor activity for the Factor I mediated C3b cleavage, and decay accelerating activity against the alternative pathway C3 convertase, C3bBb. Factor H protects self cells from complement activation but not bacteria/viruses, in that it binds to glycosaminoglycans (GAGs) that are present on host cells but not pathogen cell surfaces.
Synonyms CFH; complement factor H; beta-1H; factor H-like 1; beta-1-H-globulin; OTTHUMP00000033598; OTTHUMP00000034106; H factor 1 (complement); H factor 2 (complement); adrenomedullin binding protein; isoform b ag; e-related maculopathy susceptibility 1; FH; HF; HF1; HF2; HUS; FHL1; AHUS1; AMBP1; ARMD4; ARMS1; CFHL3; MGC88246; age-related maculopathy susceptibility 1
    • Species :
    • Cattle
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293F
    • Human Cell
    • Human Serum
    • In Vitro Cell Free System
    • Mammalian Cell
    • Mammalian cells
    • Mouse
    • Wheat Germ
    • Tag :
    • Fc
    • GST
    • His
    • T7
    • N/A
    • N-His
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Mouse Cfh-626M Recombinant Mouse Cfh Protein, His-tagged Mammalian cells His
    Human CFH-115H Native Human Factor H Human Serum N/A
    Human CFH-23H Native Human Complement factor H Human Serum N/A
    Mouse Cfh-392M Recombinant Mouse Cfh protein, His-tagged HEK293 His
    Mouse Cfh-396M Recombinant Mouse Cfh protein, Fc-tagged HEK293 Fc
    Human CFH-1168H Recombinant Human CFH Protein, GST-Tagged Wheat Germ GST
    Human CFH-26763TH Recombinant Human CFH, His-tagged E.coli His
    Human CFH-3183H Recombinant Human CFH, His tagged Human Cell His
    Human CFH-641H Recombinant Human CFH protein, His-tagged E.coli His
    Mouse Cfh-642M Recombinant Mouse Cfh protein, His & T7-tagged E.coli His/T7
    Rat Cfh-643R Recombinant Rat Cfh protein, His-tagged E.coli His
    Zebrafish CFH-7847Z Recombinant Zebrafish CFH Mammalian Cell His
    Cattle CFH-640C Recombinant Cattle CFH protein, His & T7-tagged E.coli His/T7
    Human CFH-2409HCL Recombinant Human CFH cell lysate Human Cell N/A
    Human CFH-3295HF Recombinant Full Length Human CFH Protein, GST-tagged In Vitro Cell Free System GST
    Mouse Cfh-761M Recombinant Mouse Cfh Protein, His-tagged E.coli N-His
    Human CFH-762H Recombinant Human CFH Protein, His-tagged HEK293F N-His
    Human CFH-763H Recombinant Human CFH Protein, His-tagged E.coli N-His
    Human CAB11509MH Mouse Anti-Human Complement Factor H Monoclonal Antibody Mouse N/A
    Human DMABT-H19244 Mouse Anti-CFH Monoclonal Antibody Mouse N/A

    CFH involved in several pathways and played different roles in them. We selected most pathways CFH participated on our site, such as Complement and coagulation cascades, Staphylococcus aureus infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with CFH were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Complement and coagulation cascades SERPING1; F2; CD59A; C8A; PROC; C2; C7; SERPINA1D; C1QA; CR1L
    Staphylococcus aureus infection SELP; FPR3; cgr2b; SELPLG; ITGAL; C1QC; FCGR1; C2; PTAFR; FGG

    CFH has several biochemical functions, for example, heparan sulfate proteoglycan binding, heparin binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CFH itself. We selected most functions CFH had, and list some proteins which have the same functions with CFH. You can find most of the proteins on our site.

    Function Related Protein
    heparan sulfate proteoglycan binding AGRN; SEMA5A; ITGAM; GPC4; FST; CFH; HPSE2; GPC6A; GPC1B; SLIT2
    heparin binding RPL22; FBLN7; FGF14; FGF12; CCL2; THBS3; ADAMTS1; PLA2G5; FGFBP1; CECR1
    protein binding CEBPG; DACT1; RHOH; NOMO2; CEP85; UBE3A; ANO6; NHLRC2; ING4; UBL7

    CFH has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CFH here. Most of them are supplied by our site. Hope this information will be useful for your research of CFH.

    C3; C3; ennX; TFAP2A; VDR; GRB2; SMAD3; ZBTB16; EP300; q81p70_bacan; colA; TFAP2C; YTHDC1; q99ib8-pro_0000045596; d-mannose; ALB

    Cortina, G; Trojer, R; et al. De novo tacrolimus-induced thrombotic microangiopathy in the early stage after renal transplantation successfully treated with conversion to everolimus. PEDIATRIC NEPHROLOGY 30:693-697(2015).
    Khandelwal, P; Gupta, A; et al. Effect of plasma exchange and immunosuppressive medications on antibody titers and outcome in anti-complement factor H antibody-associated hemolytic uremic syndrome. PEDIATRIC NEPHROLOGY 30:451-457(2015).

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