|Official Full Name||complement factor H|
|Background||Factor H is a member of the regulators of complement activation family and is a complement control protein. It is a large (155 kilodaltons), soluble glycoprotein that circulates in human plasma (at a concentration of 500–800 micrograms per milliliter). Its principal function is to regulate the Alternative Pathway of the complement system, ensuring that the complement system is directed towards pathogens and does not damage host tissue. Factor H regulates complement activation on self cells by possessing both cofactor activity for the Factor I mediated C3b cleavage, and decay accelerating activity against the alternative pathway C3 convertase, C3bBb. Factor H protects self cells from complement activation but not bacteria/viruses, in that it binds to glycosaminoglycans (GAGs) that are present on host cells but not pathogen cell surfaces.|
|Synonyms||CFH; complement factor H; beta-1H; factor H-like 1; beta-1-H-globulin; OTTHUMP00000033598; OTTHUMP00000034106; H factor 1 (complement); H factor 2 (complement); adrenomedullin binding protein; isoform b ag; e-related maculopathy susceptibility 1; FH; HF; HF1; HF2; HUS; FHL1; AHUS1; AMBP1; ARMD4; ARMS1; CFHL3; MGC88246; age-related maculopathy susceptibility 1|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
CFH involved in several pathways and played different roles in them. We selected most pathways CFH participated on our site, such as Complement and coagulation cascades, Staphylococcus aureus infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with CFH were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Complement and coagulation cascades||SERPING1; F2; CD59A; C8A; PROC; C2; C7; SERPINA1D; C1QA; CR1L|
|Staphylococcus aureus infection||SELP; FPR3; cgr2b; SELPLG; ITGAL; C1QC; FCGR1; C2; PTAFR; FGG|
CFH has several biochemical functions, for example, heparan sulfate proteoglycan binding, heparin binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CFH itself. We selected most functions CFH had, and list some proteins which have the same functions with CFH. You can find most of the proteins on our site.
|heparan sulfate proteoglycan binding||AGRN; SEMA5A; ITGAM; GPC4; FST; CFH; HPSE2; GPC6A; GPC1B; SLIT2|
|heparin binding||RPL22; FBLN7; FGF14; FGF12; CCL2; THBS3; ADAMTS1; PLA2G5; FGFBP1; CECR1|
|protein binding||CEBPG; DACT1; RHOH; NOMO2; CEP85; UBE3A; ANO6; NHLRC2; ING4; UBL7|
CFH has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CFH here. Most of them are supplied by our site. Hope this information will be useful for your research of CFH.
C3; C3; ennX; TFAP2A; VDR; GRB2; SMAD3; ZBTB16; EP300; q81p70_bacan; colA; TFAP2C; YTHDC1; q99ib8-pro_0000045596; d-mannose; ALB