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CLDN2

  • Official Full Name

    claudin 2

  • Overview

    This gene product belongs to the claudin protein family whose members have been identified as major integral membrane proteins localized exclusively at tight junctions. Claudins are expressed in an organ-specific manner and regulate tissue-specific physiologic properties of tight junctions. This protein is expressed in the intestine. Alternatively spliced transcript variants with different 5' untranslated region have been found for this gene.
  • Synonyms

    CLDN2; claudin 2; SP82; claudin-2; OTTHUMP00000023793; PSEC0059; UNQ705/PRO1356;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Bos taurus (Bovine)
  • Canis lupus familiaris (Dog) (Canis familiaris)
  • Chicken
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Zebrafish
  • Baculovirus-Insect cells
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • C
  • His
  • GST
  • Myc
  • DDK
  • MYC
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CLDN2-2948H Active Recombinant Human CLDN2 Full Length Transmembrane protein(Nanodisc) HEK293 N/A
Human CLDN2-1438H Recombinant Human CLDN2 Protein, GST-tagged Wheat Germ GST
Human CLDN2-26706TH Recombinant Human CLDN2 Wheat Germ N/A 52 amino acids
Human CLDN2-11292H Recombinant Human CLDN2 protein(184-230 aa), GST-tagged E.coli N-GST 184-230 aa
Human CLDN2-7466HCL Recombinant Human CLDN2 293 Cell Lysate HEK293 N/A
Human CLDN2-2052HF Recombinant Full Length Human CLDN2 Protein, GST-tagged In Vitro Cell Free System GST 230 amino acids
Human CLDN2-1091H Recombinant Human CLDN2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human CLDN2-0405H Recombinant Human CLDN2 Protein (Met1-Val230), C-His-tagged Baculovirus-Insect cells C-His Met1-Val230
Mouse Cldn2-900M Recombinant Mouse Cldn2 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Bos taurus (Bovine) RFL21893BF Recombinant Full Length Bovine Claudin-2(Cldn2) Protein, His-Tagged E.coli expression system His Full Length (1-230)
Canis lupus familiaris (Dog) (Canis familiaris) RFL23223CF Recombinant Full Length Dog Claudin-2(Cldn2) Protein, His-Tagged E.coli expression system His Full Length (1-230)
Homo sapiens (Human) RFL8713HF Recombinant Full Length Human Claudin-2(Cldn2) Protein, His-Tagged E.coli expression system His Full Length (1-230)
Mus musculus (Mouse) RFL29997MF Recombinant Full Length Mouse Claudin-2(Cldn2) Protein, His-Tagged E.coli expression system His Full Length (1-230)
Zebrafish CLDN2-1282Z Recombinant Zebrafish CLDN2 Mammalian Cell His
Chicken CLDN2-5001C Recombinant Chicken CLDN2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • CLDN2 Related Research Area

CLDN2 involved in several pathways and played different roles in them. We selected most pathways CLDN2 participated on our site, such as Cell adhesion molecules (CAMs), Tight junction, Leukocyte transendothelial migration, which may be useful for your reference. Also, other proteins which involved in the same pathway with CLDN2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cell adhesion molecules (CAMs)CD8B;CD99;ICOS;ITGB2;HLA-G;CLDN16;CDH2;BF2;MHC1UXA2
Tight junctionCLDN6;PARD6A;MRAS;EXOC4;SHROOM4;MPDZ;PPP2R1B;MYL2;CRB3A
Leukocyte transendothelial migrationNOX3;MMP9;RAP1B;PRKCB;VAV1;CLDN16;CLDN18;TXK;ACTN1
Hepatitis CPIK3R5;IFN-a;IFNA10;IFIT1;IRF1;CLDN5;IRF3;PPP2CB;CLDN16

CLDN2 has several biochemical functions, for example, identical protein binding, protein binding, structural molecule activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CLDN2 itself. We selected most functions CLDN2 had, and list some proteins which have the same functions with CLDN2. You can find most of the proteins on our site.

Function Related Protein
identical protein bindingSH3GL1;MYBPC3;MPZL2B;ACTG1;KHDC1B;AMELX;FGFR1;KDM6A;DHX8
protein bindingDYNC1LI1;DUSP9;PMF1;NOC4L;PHF20L1;EDC4;RFX1;DCP1A;TTC39B
structural molecule activityKRT96;CLDNK;CKI;KRT42;EPB41L2;CLDN7A;TUBA1A;KRT33A;CSTA

CLDN2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CLDN2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CLDN2.

KRT31; NOTCH2NL; KRTAP4-12; TJP1

  • Q&As
  • Reviews

Q&As (5)

Ask a question
Are there ongoing clinical trials related to CLDN2? 01/28/2022

Yes, there are ongoing clinical trials investigating the safety and efficacy of CLDN2-targeted therapies in various disease contexts, including cancer and inflammatory conditions.

Is CLDN2 expression uniform across different types of cancers? 11/13/2020

No, CLDN2 expression varies among different cancer types, and its role may differ depending on the specific context of the disease.

Can CLDN2 levels serve as a prognostic marker in cancer? 09/26/2020

Some studies suggest that elevated CLDN2 levels in certain cancers correlate with a poorer prognosis, making it a potential prognostic marker.

How might CLDN2-targeted therapies benefit patients with inflammatory bowel diseases? 02/10/2019

Modulating CLDN2 expression could help restore epithelial barrier function in the intestines, potentially offering a new avenue for the treatment of inflammatory bowel diseases.

How is CLDN2 expression regulated in normal physiological conditions? 01/08/2019

The regulation of CLDN2 expression involves complex signaling pathways, and understanding these mechanisms is crucial for developing targeted therapies.

Customer Reviews (3)

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Reviews
05/31/2021

    Its superior binding affinity and specificity enable accurate and reliable detection of target analytes in various biological samples.

    12/15/2018

      Its stability and well-defined structure make it an excellent candidate for visualizing and understanding the three-dimensional arrangement of proteins at a high resolution.

      03/07/2017

        CLDN2 protein has proven to be instrumental in protein electron microscopy structure analysis.

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