CLDN2
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Official Full Name
claudin 2
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Overview
This gene product belongs to the claudin protein family whose members have been identified as major integral membrane proteins localized exclusively at tight junctions. Claudins are expressed in an organ-specific manner and regulate tissue-specific physiologic properties of tight junctions. This protein is expressed in the intestine. Alternatively spliced transcript variants with different 5' untranslated region have been found for this gene. -
Synonyms
CLDN2; claudin 2; SP82; claudin-2; OTTHUMP00000023793; PSEC0059; UNQ705/PRO1356;
- Recombinant Proteins
- Cell & Tissue Lysates
- Bos taurus (Bovine)
- Canis lupus familiaris (Dog) (Canis familiaris)
- Chicken
- Homo sapiens (Human)
- Human
- Mouse
- Mus musculus (Mouse)
- Zebrafish
- Baculovirus-Insect cells
- E.coli
- E.coli expression system
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- C
- His
- GST
- Myc
- DDK
- MYC
- N/A
- N
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Human | CLDN2-2948H | Active Recombinant Human CLDN2 Full Length Transmembrane protein(Nanodisc) | HEK293 | N/A | ||
Human | CLDN2-1438H | Recombinant Human CLDN2 Protein, GST-tagged | Wheat Germ | GST | ||
Human | CLDN2-26706TH | Recombinant Human CLDN2 | Wheat Germ | N/A | 52 amino acids | |
Human | CLDN2-11292H | Recombinant Human CLDN2 protein(184-230 aa), GST-tagged | E.coli | N-GST | 184-230 aa | |
Human | CLDN2-7466HCL | Recombinant Human CLDN2 293 Cell Lysate | HEK293 | N/A | ||
Human | CLDN2-2052HF | Recombinant Full Length Human CLDN2 Protein, GST-tagged | In Vitro Cell Free System | GST | 230 amino acids | |
Human | CLDN2-1091H | Recombinant Human CLDN2 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Myc/DDK | ||
Human | CLDN2-0405H | Recombinant Human CLDN2 Protein (Met1-Val230), C-His-tagged | Baculovirus-Insect cells | C-His | Met1-Val230 | |
Mouse | Cldn2-900M | Recombinant Mouse Cldn2 Protein, MYC/DDK-tagged | HEK293T | MYC/DDK | ||
Bos taurus (Bovine) | RFL21893BF | Recombinant Full Length Bovine Claudin-2(Cldn2) Protein, His-Tagged | E.coli expression system | His | Full Length (1-230) | |
Canis lupus familiaris (Dog) (Canis familiaris) | RFL23223CF | Recombinant Full Length Dog Claudin-2(Cldn2) Protein, His-Tagged | E.coli expression system | His | Full Length (1-230) | |
Homo sapiens (Human) | RFL8713HF | Recombinant Full Length Human Claudin-2(Cldn2) Protein, His-Tagged | E.coli expression system | His | Full Length (1-230) | |
Mus musculus (Mouse) | RFL29997MF | Recombinant Full Length Mouse Claudin-2(Cldn2) Protein, His-Tagged | E.coli expression system | His | Full Length (1-230) | |
Zebrafish | CLDN2-1282Z | Recombinant Zebrafish CLDN2 | Mammalian Cell | His | ||
Chicken | CLDN2-5001C | Recombinant Chicken CLDN2 | Mammalian Cell | His |
- Involved Pathway
- Protein Function
- Interacting Protein
- CLDN2 Related Research Area
CLDN2 involved in several pathways and played different roles in them. We selected most pathways CLDN2 participated on our site, such as Cell adhesion molecules (CAMs), Tight junction, Leukocyte transendothelial migration, which may be useful for your reference. Also, other proteins which involved in the same pathway with CLDN2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Cell adhesion molecules (CAMs) | CD8B;CD99;ICOS;ITGB2;HLA-G;CLDN16;CDH2;BF2;MHC1UXA2 |
Tight junction | CLDN6;PARD6A;MRAS;EXOC4;SHROOM4;MPDZ;PPP2R1B;MYL2;CRB3A |
Leukocyte transendothelial migration | NOX3;MMP9;RAP1B;PRKCB;VAV1;CLDN16;CLDN18;TXK;ACTN1 |
Hepatitis C | PIK3R5;IFN-a;IFNA10;IFIT1;IRF1;CLDN5;IRF3;PPP2CB;CLDN16 |
CLDN2 has several biochemical functions, for example, identical protein binding, protein binding, structural molecule activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CLDN2 itself. We selected most functions CLDN2 had, and list some proteins which have the same functions with CLDN2. You can find most of the proteins on our site.
Function | Related Protein |
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identical protein binding | SH3GL1;MYBPC3;MPZL2B;ACTG1;KHDC1B;AMELX;FGFR1;KDM6A;DHX8 |
protein binding | DYNC1LI1;DUSP9;PMF1;NOC4L;PHF20L1;EDC4;RFX1;DCP1A;TTC39B |
structural molecule activity | KRT96;CLDNK;CKI;KRT42;EPB41L2;CLDN7A;TUBA1A;KRT33A;CSTA |
CLDN2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CLDN2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CLDN2.
KRT31; NOTCH2NL; KRTAP4-12; TJP1
- Q&As
- Reviews
Q&As (5)
Ask a questionYes, there are ongoing clinical trials investigating the safety and efficacy of CLDN2-targeted therapies in various disease contexts, including cancer and inflammatory conditions.
No, CLDN2 expression varies among different cancer types, and its role may differ depending on the specific context of the disease.
Some studies suggest that elevated CLDN2 levels in certain cancers correlate with a poorer prognosis, making it a potential prognostic marker.
Modulating CLDN2 expression could help restore epithelial barrier function in the intestines, potentially offering a new avenue for the treatment of inflammatory bowel diseases.
The regulation of CLDN2 expression involves complex signaling pathways, and understanding these mechanisms is crucial for developing targeted therapies.
Customer Reviews (3)
Write a reviewIts superior binding affinity and specificity enable accurate and reliable detection of target analytes in various biological samples.
Its stability and well-defined structure make it an excellent candidate for visualizing and understanding the three-dimensional arrangement of proteins at a high resolution.
CLDN2 protein has proven to be instrumental in protein electron microscopy structure analysis.
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