cul1
Share
  • Official Full Name
  • cullin 1
  • Background
  • Cullin 1, also known as CUL1, is a human protein and gene from cullin family. This protein plays an important role in protein degradation and protein ubiquitination. This is an essential component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, it serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme.
  • Synonyms
  • CUL1; cullin 1; MGC149834; MGC149835; cullin-1; CUL-1; OTTHUMP00000202347
Cat.#:CUL1-2130HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CUL1 Protein, GST-tagged
+Inquiry
Cat.#:CUL1-648HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CUL1 Protein, His-tagged
+Inquiry
Cat.#:CUL1-11701HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CUL1, GST-tagged
+Inquiry
Cat.#:CUL1-146HTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human CUL1/RBX1
+Inquiry
Cat.#:CUL1-147HTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human CUL1/RBX1/SKP1
+Inquiry
Cat.#:CUL1-26258THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CUL1 protein, His-tagged
+Inquiry
Cat.#:CUL1-28050THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CUL1, His-tagged
+Inquiry
Cat.#:CUL1-4989HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Cullin 1, His-tagged
+Inquiry
Cat.#:CUL1-4075MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse CUL1 Protein
+Inquiry
Cat.#:CUL1-7185HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human CUL1 293 Cell Lysate
+Inquiry

Involved Pathway

CUL1 involved in several pathways and played different roles in them. We selected most pathways CUL1 participated on our site, such as Cell cycle, Oocyte meiosis, Ubiquitin mediated proteolysis, which may be useful for your reference. Also, other proteins which involved in the same pathway with CUL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cell cycle
TERF2; YWHAE1; CDC25C; TUBGCP4; CETN2; CKAP5; YWHABB; DYNC1I2; CEP63; TFDP2
Oocyte meiosis
PRKACG; CDC23; PPP1R2P9; FBXO43; SPDYA; PPP2R5EA; CALM2B; ADCY1A; RPS6KA2; SLKA
Ubiquitin mediated proteolysis
UBE2D3; ANAPC5; SIAH2L; BTRC; UBE2E1; CBL; UBE2G1B; CDC34; KEAP1B; FBXW11
Protein processing in endoplasmic reticulum
SEC61G; PDIA6; DNAJB11; MAPK8; DNAJC5G; DAD1; WFS1; EIF2AK3; LMAN1; PDIA3
Wnt signaling pathway
PPP3CA; INVS; WNT1; PRKACA; PPARDB; SFRP1; FZD3B; ROCK2; AXIN1; FBXW11B
TGF-beta signaling pathway
BMPR1AB; CHRD; TGFB2; BMPR2B; GDF5; BMPR2A; BMP7; SMAD2; SMAD7; NOG3
Circadian rhythm
PRKAG1; PER2; NPAS2; RORC; PRKAG2; PRKAA2; PRKAG3; ARNTL; PRKAB1; PER1
Herpes simplex infection
EP300; SRSF7; MAPK10; SOCS3; IFIT1; SRSF2B; HLA-F; PVRL1B; HLA-DRA; Ifna15

Protein Function

CUL1 has several biochemical functions, for example, protein binding, contributes_to ubiquitin protein ligase activity, ubiquitin protein ligase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CUL1 itself. We selected most functions CUL1 had, and list some proteins which have the same functions with CUL1. You can find most of the proteins on our site.
Function
Related Protein
Function protein binding
Related Protein PINK1; SEMA7A; ERLEC1; RNF149; DSG1A; MAGEA3; SLAMF1; SHISA5; PTPMT1; PROM1
Function contributes_to ubiquitin protein ligase activity
Related Protein CUL3; ANAPC2; FBXL4; FBXL5; CUL1B; MED12; CUL1A; CUL2; FBXL20; FBXL17
Function ubiquitin protein ligase binding
Related Protein MID1; XRCC5; TOLLIP; GGN; PRR5L; H2-AB1; UBE2A; PRKACB; UBE2KA; NLK

Interacting Protein

CUL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CUL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CUL1.
RBX1; SKP1

CUL1 Related Articles

Ramakrishnan, R; Liu, HB; et al. Identification of novel CDK9 and Cyclin T1-associated protein complexes (CCAPs) whose siRNA depletion enhances HIV-1 Tat function. RETROVIROLOGY 9:-(2012).
Surjit, M; Varshney, B; et al. The ORF2 glycoprotein of hepatitis E virus inhibits cellular NF-kappa B activity by blocking ubiquitination mediated proteasomal degradation of I kappa B alpha in human hepatoma cells. BMC BIOCHEMISTRY 13:-(2012).