Interleukin 8 receptor, alpha is a chemokine receptor. IL8RA is its human gene. IL8RA has also been designated CD181 (cluster of differentiation 181), and CXCR1. CXCR1 is now the IUPHAR Committee on Receptor Nomenclature and Drug Classification recommended name. The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. Knockout studies in mice suggested that this protein inhibits embryonic oligodendrocyte precursor migration in developing spinal cord. This gene, IL8RB, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36.
CXCR1 involved in several pathways and played different roles in them. We selected most pathways CXCR1 participated on our site, such as Cytokine-cytokine receptor interaction, Chemokine signaling pathway, Phospholipase D signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CXCR1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
CXCR1 has several biochemical functions, for example, G-protein coupled receptor activity, chemokine receptor activity, interleukin-8 binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CXCR1 itself. We selected most functions CXCR1 had, and list some proteins which have the same functions with CXCR1. You can find most of the proteins on our site.
CXCR1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CXCR1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CXCR1.
UBE2C; CDK1; TUBA1A; PDCD6IP
Muller-Edenborn, B; Frick, R; et al. Volatile anaesthetics reduce neutrophil inflammatory response by interfering with CXC receptor-2 signalling. BRITISH JOURNAL OF ANAESTHESIA 114:143-149(2015).
Khurram, SA; Bingle, L; et al. The chemokine receptors CXCR1 and CXCR2 regulate oral cancer cell behaviour. JOURNAL OF ORAL PATHOLOGY & MEDICINE 43:667-674(2014).