CXCR1

  • Official Full Name

    chemokine (C-X-C motif) receptor 1

  • Overview

    Interleukin 8 receptor, alpha is a chemokine receptor. IL8RA is its human gene. IL8RA has also been designated CD181 (cluster of differentiation 181), and CXCR1. CXCR1 is now the IUPHAR Committee on Receptor Nomenclature and Drug Classification recommended name. The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. Knockout studies in mice suggested that this protein inhibits embryonic oligodendrocyte precursor migration in developing spinal cord. This gene, IL8RB, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36.
  • Synonyms

    chemokine (C-X-C motif) receptor 1; Interleukin 8 receptor, alpha; CXCR1; C-C; C-C-CKR-1; CD128; CD181; CDw128a; CKR-1; CMKAR1; IL8R1; IL8RBA; IL8RA;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Assay Kits
  • Gorilla gorilla gorilla (Western lowland gorilla)
  • Homo sapiens (Human)
  • Hoolock hoolock (Western hoolock gibbon) (Bunopithecus hoolock)
  • Human
  • Macaca mulatta (Rhesus macaque)
  • Mus musculus (Mouse)
  • Oryctolagus cuniculus (Rabbit)
  • Pan troglodytes (Chimpanzee)
  • Pongo pygmaeus (Bornean orangutan)
  • Rat
  • Rattus norvegicus (Rat)
  • Rhesus Macaque
  • E.coli
  • E.coli expression system
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • Flag
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CXCR1-2177H Recombinant Human CXCR1 Protein, GST-tagged Wheat Germ GST
Human CXCR1-235H Recombinant Human CXCR1 Mammalian Cell His
Human CXCR1-2176H Recombinant Human CXCR1 Protein Wheat Germ N/A
Human CXCR1-7164HCL Recombinant Human CXCR1 293 Cell Lysate HEK293 N/A
Human CXCR1-2762H-B Recombinant Human CXCR1 Protein Pre-coupled Magnetic Beads HEK293
Human CXCR1-2199H Recombinant Human CXCR1 protein, His-tagged E.coli His Asp265-Leu350
Human CXCR1-1080HFL Recombinant Human CXCR1 protein, His&Flag-tagged HEK293 His&Flag 1-350 aa
Human CXCR1-2301HF Recombinant Full Length Human CXCR1 Protein In Vitro Cell Free System 350 amino acids
Human CXCR1-1217H Recombinant Human CXCR1 Protein (Asp265-Leu350), N-GST tagged E.coli N-GST Asp265-Leu350
Human CXCR1-2302HF Recombinant Full Length Human CXCR1 Protein, GST-tagged In Vitro Cell Free System GST 350 amino acids
Human CXCR1-2762H Recombinant Human CXCR1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human CXCR1-9232H Recombinant Human CXCR1 Full Length Transmembrane protein(Nanodisc) HEK293 N/A
Rat CXCR1-1692R Recombinant Rat CXCR1 Protein Mammalian Cell His
Rat CXCR1-1351R Recombinant Rat CXCR1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat CXCR1-1351R-B Recombinant Rat CXCR1 Protein Pre-coupled Magnetic Beads HEK293
Gorilla gorilla gorilla (Western lowland gorilla) RFL1654GF Recombinant Full Length Gorilla Gorilla Gorilla C-X-C Chemokine Receptor Type 1(Cxcr1) Protein, His-Tagged E.coli expression system His Full Length (1-350)
Homo sapiens (Human) RFL10112HF Recombinant Full Length Human C-X-C Chemokine Receptor Type 1(Cxcr1) Protein, His-Tagged E.coli expression system His Full Length (1-350)
Hoolock hoolock (Western hoolock gibbon) (Bunopithecus hoolock) RFL11307HF Recombinant Full Length Bunopithecus Hoolock C-X-C Chemokine Receptor Type 1(Cxcr1) Protein, His-Tagged E.coli expression system His Full Length (1-351)
Macaca mulatta (Rhesus macaque) RFL23692MF Recombinant Full Length Macaca Mulatta C-X-C Chemokine Receptor Type 1(Cxcr1) Protein, His-Tagged E.coli expression system His Full Length (1-351)
Mus musculus (Mouse) RFL8778MF Recombinant Full Length Mouse C-X-C Chemokine Receptor Type 1(Cxcr1) Protein, His-Tagged E.coli expression system His Full Length (1-351)
Oryctolagus cuniculus (Rabbit) RFL11363OF Recombinant Full Length Rabbit C-X-C Chemokine Receptor Type 1(Cxcr1) Protein, His-Tagged E.coli expression system His Full Length (1-355)
Pan troglodytes (Chimpanzee) RFL2975PF Recombinant Full Length Pan Troglodytes C-X-C Chemokine Receptor Type 1(Cxcr1) Protein, His-Tagged E.coli expression system His Full Length (1-350)
Pongo pygmaeus (Bornean orangutan) RFL9114PF Recombinant Full Length Pongo Pygmaeus C-X-C Chemokine Receptor Type 1(Cxcr1) Protein, His-Tagged E.coli expression system His Full Length (1-351)
Rattus norvegicus (Rat) RFL7761RF Recombinant Full Length Rat C-X-C Chemokine Receptor Type 1(Cxcr1) Protein, His-Tagged E.coli expression system His Full Length (1-349)
Rhesus Macaque CXCR1-1113R Recombinant Rhesus monkey CXCR1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque CXCR1-938R Recombinant Rhesus Macaque CXCR1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque CXCR1-938R-B Recombinant Rhesus Macaque CXCR1 Protein Pre-coupled Magnetic Beads HEK293
Kit-0891 TR-FRET PPAR gamma Coactivator Assay Kit, goat N/A
Kit-1052 Cell Transformation Assay Kit (Fluorometric) N/A
Kit-1188 CXCR1 (IL8RA) U2OS β-Arrestin GPCR Assay Kit N/A
Kit-1189 cAMP CXCR1 CHO-K1 GPCR Assay Kit N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

CXCR1 involved in several pathways and played different roles in them. We selected most pathways CXCR1 participated on our site, such as Cytokine-cytokine receptor interaction, Chemokine signaling pathway, Phospholipase D signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CXCR1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cytokine-cytokine receptor interactionIL5;TNFRSF21;IL1R1;CX3CR1;CCL27;PDGFAA;IFNG1-2;FLT1;Ccl12
Chemokine signaling pathwayVAV2;MAPK3;DOCK2;WASL;PRKACB;GNGT2;GNG10;CCL21;CXCL9
Phospholipase D signaling pathwaySHC3;IL-8;AGPAT4;AKT1;PIK3R3;CYTH1;Pdgfa&Pdgfb;AVPR2;RRAS
EndocytosisCYTH1B;RAB11A;VPS37C;CAPZA1A;FLT1;WIPF2B;EGFRA;FOLR3;BF1
Epithelial cell signaling in Helicobacter pylori infectionATP6AP1;ATP6V0D1;MAPK8;TJP1;LYN;RELA;ATP6V0A2;F11R;MAPK11

CXCR1 has several biochemical functions, for example, G-protein coupled receptor activity, chemokine receptor activity, interleukin-8 binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CXCR1 itself. We selected most functions CXCR1 had, and list some proteins which have the same functions with CXCR1. You can find most of the proteins on our site.

Function Related Protein
G-protein coupled receptor activityTPRA1;F2RL2;AGTR1B;GPR30;TAS2R120;OPN1MW3;PARAPINOPSINB;PRLHR;GPR34A
chemokine receptor activityCCR6;CCRL2;CXCR3;GPR17;CXCR4A;CCR1L1;CX3CR1;CXCR4B;CCR12A
interleukin-8 bindingCXCR2;A2M;CXCR1
interleukin-8 receptor activityCXCR1;CXCR2

CXCR1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CXCR1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CXCR1.

UBE2C; CDK1; TUBA1A; PDCD6IP

Gene Family

IL Chemokines Cytokines

Research Area

Related articles

Muller-Edenborn, B; Frick, R; et al. Volatile anaesthetics reduce neutrophil inflammatory response by interfering with CXC receptor-2 signalling. BRITISH JOURNAL OF ANAESTHESIA 114:143-149(2015).
Khurram, SA; Bingle, L; et al. The chemokine receptors CXCR1 and CXCR2 regulate oral cancer cell behaviour. JOURNAL OF ORAL PATHOLOGY & MEDICINE 43:667-674(2014).
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