CXCR3
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Official Full Name
chemokine (C-X-C motif) receptor 3
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Overview
This gene encodes a G protein-coupled receptor with selectivity for three chemokines, termed CXCL9/Mig (monokine induced by interferon-g), CXCL10/IP10 (interferon-g-inducible 10 kDa protein) and CXCL11/I-TAC (interferon-inducible T cell a-chemoattractant). Binding of chemokines to this protein induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the isoforms (CXCR3-B) shows high affinity binding to chemokine, CXCL4/PF4 (PMID:12782716). [provided by RefSeq, Jun 2011] -
Synonyms
CXCR3; chemokine (C-X-C motif) receptor 3; GPR9; MigR; CD182; CD183; Mig-R; CKR-L2; CMKAR3; IP10-R; C-X-C chemokine receptor type 3; CXC-R3; CXCR-3; Mig receptor; IP10 receptor; IP-10 receptor; G protein-coupled receptor 9; chemokine (C-X-C) receptor 3; interferon-inducible protein 10 receptor;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Assay Kits
- Bos taurus (Bovine)
- Canis lupus familiaris (Dog) (Canis familiaris)
- Goat
- Human
- Mouse
- Mus musculus (Mouse)
- Rat
- Rattus norvegicus (Rat)
- Rhesus Macaque
- E.coli
- E.coli expression system
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- KSI
- N/A
- N
- C
- Involved Pathway
- Protein Function
- Interacting Protein
- CXCR3 Related Articles
- CXCR3 Related Gene Family
- CXCR3 Related Research Area
CXCR3 involved in several pathways and played different roles in them. We selected most pathways CXCR3 participated on our site, such as Cytokine-cytokine receptor interaction, Chemokine signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CXCR3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cytokine-cytokine receptor interaction | ACVR1L;CSF1R;CCL22;CSF1;XCR1;ACVR1BA;CXCR4;BMP7;IL24 |
| Chemokine signaling pathway | GNG8;NCF1;PRKACG;CCL18;CCL3L1;PRKACA;CXCL2;RAP1A;IL-8 |
CXCR3 has several biochemical functions, for example, C-X-C chemokine binding, C-X-C chemokine receptor activity, chemokine binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CXCR3 itself. We selected most functions CXCR3 had, and list some proteins which have the same functions with CXCR3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| C-X-C chemokine binding | CXCR6;HMGB1;CXCR3;CXCR7 |
| C-X-C chemokine receptor activity | CXCR4A;CCR9A;CXCR3.1;CXCR7;CXCR3;CXCR2;CCBP2;CXCR5;CXCR4 |
| chemokine binding | CXCR3;PLP2;ACKR3B;ACKR4 |
| chemokine receptor activity | RGRA;CCR9A;CCBP2;CXCR1;CCR5;CMKLR1;CXCR3;RGRB;GPR17 |
| receptor activity | UBXN6;FPR3;CD93;OGFRL1;SEMA4D;XPR1;Tnfrsf22;GRIN2BB;CADM4 |
CXCR3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CXCR3 here. Most of them are supplied by our site. Hope this information will be useful for your research of CXCR3.
- Q&As
- Reviews
Q&As (7)
Ask a questionThe primary role of chemokines and their receptors, including CXCR3, is in the recruitment, activation, and differentiation of immune cells.
There are three variant isoforms of CXCR3: CXCR3A, CXCR3B, and CXCR3alt.
The ligands associated with the chemokine receptor CXCR3 are CXCL9, CXCL10, and CXCL11, and they play key roles during interferon-induced inflammatory responses.
The relative contributions of different CXCR3 chemokines and the three variant isoforms to the inflammatory process in human skin require further investigation.
The review focuses on the biology of CXCR3 and its associated ligands, with particular emphasis on their roles in the skin during inflammation and carcinogenesis.
In skin cancers, the CXCR3 receptor can play a dual role. Its expression on tumor cells can lead to cancer metastasis, while expression on immune cells can promote anti-tumor immune responses.
The expression of CXCL9, CXCL10, and CXCL11 is driven by inflammation of the skin resulting from infections or autoimmune disease, leading to the recruitment of effector, CXCR3+ T cells from the circulation.
Customer Reviews (3)
Write a reviewThe continuous innovation and improvements made by the manufacturer indicated a promising future for the product.
Inclusion of the product consistently led to a significant upregulation of target protein expression levels.
We were excited about the product's role in driving future discoveries in our field of study.
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