|Official Full Name||chemokine (C-X-C motif) receptor 3|
|Background||This gene encodes a G protein-coupled receptor with selectivity for three chemokines, termed CXCL9/Mig (monokine induced by interferon-g), CXCL10/IP10 (interferon-g-inducible 10 kDa protein) and CXCL11/I-TAC (interferon-inducible T cell a-chemoattractant). Binding of chemokines to this protein induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the isoforms (CXCR3-B) shows high affinity binding to chemokine, CXCL4/PF4 (PMID:12782716). [provided by RefSeq, Jun 2011]|
|Synonyms||CXCR3; chemokine (C-X-C motif) receptor 3; GPR9; MigR; CD182; CD183; Mig-R; CKR-L2; CMKAR3; IP10-R; C-X-C chemokine receptor type 3; CXC-R3; CXCR-3; Mig receptor; IP10 receptor; IP-10 receptor; G protein-coupled receptor 9; chemokine (C-X-C) receptor 3; interferon-inducible protein 10 receptor;|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
cxcr3 involved in several pathways and played different roles in them. We selected most pathways cxcr3 participated on our site, such as Cytokine-cytokine receptor interaction, Chemokine signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with cxcr3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Cytokine-cytokine receptor interaction||IL2RG; CCR7; M17; IFNE; CCL4L1; IFNA13; EDA2R; CCR6A; CXCL12A; KDR|
|Chemokine signaling pathway||SHC3; NFKBIA; GM1987; CCL8; PREX1; RHOA; JAK2; AMCF-II; GM13304; NFKBIB|
cxcr3 has several biochemical functions, for example, C-X-C chemokine binding, C-X-C chemokine receptor activity, chemokine binding. Some of the functions are cooperated with other proteins, some of the functions could acted by cxcr3 itself. We selected most functions cxcr3 had, and list some proteins which have the same functions with cxcr3. You can find most of the proteins on our site.
|C-X-C chemokine binding||HMGB1; CXCR7; CXCR6; CXCR3|
|C-X-C chemokine receptor activity||CXCR7; CXCR3.1; CCR9A; CXCR3; CXCR4A; CXCR2; CCBP2; CXCR4B; CXCR6; CXCR5|
|chemokine binding||PLP2; ACKR3B; CXCR3; ACKR4|
|chemokine receptor activity||ACKR3B; RGRB; GPR17; CCBP2; CCR6A; RGRA; PRLH2R; CX3CR1; CXCR3; CCR8|
|receptor activity||PAQR9; ANTXRL; EDA2R; NOTCH1B; RAMP3; TIGIT; GUCY1A3; TNFRSF13B; VMN1R41; TREML2|
cxcr3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with cxcr3 here. Most of them are supplied by our site. Hope this information will be useful for your research of cxcr3.