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Official Full Name chemokine (C-X-C motif) receptor 3
Background This gene encodes a G protein-coupled receptor with selectivity for three chemokines, termed CXCL9/Mig (monokine induced by interferon-g), CXCL10/IP10 (interferon-g-inducible 10 kDa protein) and CXCL11/I-TAC (interferon-inducible T cell a-chemoattractant). Binding of chemokines to this protein induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the isoforms (CXCR3-B) shows high affinity binding to chemokine, CXCL4/PF4 (PMID:12782716). [provided by RefSeq, Jun 2011]
Synonyms CXCR3; chemokine (C-X-C motif) receptor 3; GPR9; MigR; CD182; CD183; Mig-R; CKR-L2; CMKAR3; IP10-R; C-X-C chemokine receptor type 3; CXC-R3; CXCR-3; Mig receptor; IP10 receptor; IP-10 receptor; G protein-coupled receptor 9; chemokine (C-X-C) receptor 3; interferon-inducible protein 10 receptor;
    • Species :
    • Human
    • Rat
    • Rhesus Macaque
    • Source :
    • E. coli
    • HEK293
    • in vitro E. coli
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CXCR3-16H Recombinant Human CXCR3 protein, GST-tagged Wheat Germ GST
    Human CXCR3-17H Recombinant Human CXCR3 protein Wheat Germ N/A
    Human CXCR3-261H Recombinant Human CXCR3 protein, His-tagged E. coli His
    Human CXCR3-26725TH Recombinant Human CXCR3 Wheat Germ N/A
    Human CXCR3-2709H Recombinant Human CXCR3 Protein (1-368 aa), His-tagged in vitro E. coli His
    Human CXCR3-28064TH Recombinant Human CXCR3, GST-tagged Wheat Germ GST
    Human CXCR3-7162HCL Recombinant Human CXCR3 293 Cell Lysate HEK293 N/A
    Rat CXCR3-1694R Recombinant Rat CXCR3 Protein Mammalian Cell His
    Rhesus Macaque CXCR3-1114R Recombinant Rhesus monkey CXCR3 Protein, His-tagged Mammalian Cell His
    Kit-0924 CYP1A2 Blue Screening Kit N/A
    Kit-1040 FAD Colorimetric/Fluorometric Assay Kit N/A
    Kit-1194 CXCR3 Activated GPCR Internalization Assay Kit N/A
    Kit-1196 cAMP CXCR3 CHO-K1 GPCR Assay Kit N/A

    CXCR3 involved in several pathways and played different roles in them. We selected most pathways CXCR3 participated on our site, such as Cytokine-cytokine receptor interaction, Chemokine signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CXCR3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine-cytokine receptor interaction IL17A; XCL2; PRP2; CCR8L; BMP7; IL22RA1; CCL20; OSM; CCL27; IL5
    Chemokine signaling pathway VAV2; ADRBK2; CRK; CCL2; CXCL14; STAT2; HCK; GRK6; PLCB1; CCR6

    CXCR3 has several biochemical functions, for example, C-X-C chemokine binding, C-X-C chemokine receptor activity, chemokine binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CXCR3 itself. We selected most functions CXCR3 had, and list some proteins which have the same functions with CXCR3. You can find most of the proteins on our site.

    Function Related Protein
    C-X-C chemokine binding CXCR6; HMGB1; CXCR7; CXCR3
    C-X-C chemokine receptor activity CCBP2; CXCR6; CXCR4A; CCR9A; CXCR4; CXCR3.1; CXCR7; CXCR5; CXCR2; CXCR3
    chemokine binding CXCR3; ACKR3B; PLP2; ACKR4
    chemokine receptor activity ACKR4; CCR1L1; CXCR3; CMKLR1; CX3CR1; CXCR3.1; XCR1; CCR12A; CCBP2; CCR5
    receptor activity ITGB3A; HTR3A; EPHB6; PAQR3A; KRT1; AMFR; GRIN2BB; PVRL3B; NLGN4B; ERBB3B

    CXCR3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CXCR3 here. Most of them are supplied by our site. Hope this information will be useful for your research of CXCR3.

    Tan, JF; Jin, XF; et al. Beneficial effect of T follicular helper cells on antibody class switching of B cells in prostate cancer. ONCOLOGY REPORTS 33:1512-1518(2015).
    Wang, J; Vodovotz, Y; et al. Injury-induced MRP8/MRP14 stimulates IP-10/CXCL10 in monocytes/macrophages. FASEB JOURNAL 29:250-262(2015).

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