• Official Full Name
  • chemokine (C-X-C motif) receptor 3
  • Background
  • This gene encodes a G protein-coupled receptor with selectivity for three chemokines, termed CXCL9/Mig (monokine induced by interferon-g), CXCL10/IP10 (interferon-g-inducible 10 kDa protein) and CXCL11/I-TAC (interferon-inducible T cell a-chemoattractant). Binding of chemokines to this protein induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the isoforms (CXCR3-B) shows high affinity binding to chemokine, CXCL4/PF4 (PMID:12782716). [provided by RefSeq, Jun 2011]
  • Synonyms
  • CXCR3; chemokine (C-X-C motif) receptor 3; GPR9; MigR; CD182; CD183; Mig-R; CKR-L2; CMKAR3; IP10-R; C-X-C chemokine receptor type 3; CXC-R3; CXCR-3; Mig receptor; IP10 receptor; IP-10 receptor; G protein-coupled receptor 9; chemokine (C-X-C) receptor 3; interferon-inducible protein 10 receptor;
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CXCR3 protein, GST-tagged
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CXCR3 protein
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human CXCR3
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human CXCR3, GST-tagged
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat CXCR3 Protein
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey CXCR3 Protein, His-tagged
Source (Host):Species:Human
Product nameRecombinant Human CXCR3 293 Cell Lysate
Source (Host):Species:
Product nameCXCR3 Activated GPCR Internalization Assay Kit
Source (Host):Species:
Product namecAMP CXCR3 CHO-K1 GPCR Assay Kit
Source (Host):Species:
Product nameFAD Colorimetric/Fluorometric Assay Kit
Source (Host):Species:
Product nameCYP1A2 Blue Screening Kit

Involved Pathway

CXCR3 involved in several pathways and played different roles in them. We selected most pathways CXCR3 participated on our site, such as Cytokine-cytokine receptor interaction, Chemokine signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CXCR3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cytokine-cytokine receptor interaction
HGF; CCR1L1; TNFSF15; IFNA2; GM13306; CCL20B; TGFB1; IL22RA2; LEPR; IL18R1
Chemokine signaling pathway

Protein Function

CXCR3 has several biochemical functions, for example, C-X-C chemokine binding, C-X-C chemokine receptor activity, chemokine binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CXCR3 itself. We selected most functions CXCR3 had, and list some proteins which have the same functions with CXCR3. You can find most of the proteins on our site.
Related Protein
Function C-X-C chemokine binding
Related Protein HMGB1; CXCR3; CXCR6; CXCR7
Function C-X-C chemokine receptor activity
Related Protein CXCR7; CXCR5; CXCR6; CCR9A; CXCR4; CXCR3; CXCR2; CXCR4B; CXCR3.1; CXCR4A
Function chemokine binding
Related Protein CXCR3; PLP2; ACKR4; ACKR3B
Function chemokine receptor activity
Related Protein CXCR4B; CCR1; CCR6; CCR3; CCR9A; CCR1L1; CCR12A; ACKR3B; CXCR3.2; CCR5
Function receptor activity
Related Protein ICAM1; ATP6AP2; TRAM1; SEMA4D; FOLR1; DERL1; TIGIT; Siglece; NLGN3B; NR2C2

CXCR3 Related Articles

Tan, JF; Jin, XF; et al. Beneficial effect of T follicular helper cells on antibody class switching of B cells in prostate cancer. ONCOLOGY REPORTS 33:1512-1518(2015).
Wang, J; Vodovotz, Y; et al. Injury-induced MRP8/MRP14 stimulates IP-10/CXCL10 in monocytes/macrophages. FASEB JOURNAL 29:250-262(2015).

CXCR3 Related Gene Family

GPCRs Chemokines Cytokines