CXCR3

  • Official Full Name

    chemokine (C-X-C motif) receptor 3

  • Overview

    This gene encodes a G protein-coupled receptor with selectivity for three chemokines, termed CXCL9/Mig (monokine induced by interferon-g), CXCL10/IP10 (interferon-g-inducible 10 kDa protein) and CXCL11/I-TAC (interferon-inducible T cell a-chemoattractant). Binding of chemokines to this protein induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the isoforms (CXCR3-B) shows high affinity binding to chemokine, CXCL4/PF4 (PMID:12782716). [provided by RefSeq, Jun 2011]
  • Synonyms

    CXCR3; chemokine (C-X-C motif) receptor 3; GPR9; MigR; CD182; CD183; Mig-R; CKR-L2; CMKAR3; IP10-R; C-X-C chemokine receptor type 3; CXC-R3; CXCR-3; Mig receptor; IP10 receptor; IP-10 receptor; G protein-coupled receptor 9; chemokine (C-X-C) receptor 3; interferon-inducible protein 10 receptor;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Assay Kits
  • Bos taurus (Bovine)
  • Canis lupus familiaris (Dog) (Canis familiaris)
  • Goat
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Rat
  • Rattus norvegicus (Rat)
  • Rhesus Macaque
  • E.coli
  • E.coli expression system
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • KSI
  • N/A
  • N
  • C
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CXCR3-16H Recombinant Human CXCR3 protein, GST-tagged Wheat Germ GST
Human CXCR3-26725TH Recombinant Human CXCR3 Wheat Germ N/A 53 amino acids
Human CXCR3-28064TH Recombinant Human CXCR3, GST-tagged Wheat Germ GST
Human CXCR3-7162HCL Recombinant Human CXCR3 293 Cell Lysate HEK293 N/A
Human CXCR3-177H Active Recombinant Human CXCR3 Full Length Transmembrane protein(VLPs) HEK293 N/A Val 2 - Leu 368
Human CXCR3-2778H Recombinant Human CXCR3 protein, His-GST-tagged E.coli His/GST 4-50aa
Human CXCR3-2709H Recombinant Human CXCR3 Full Length Transmembrane protein (1-368 aa), His-tagged E.coli N-His 1-368 aa
Human CXCR3-1070H Recombinant Human CXCR3 Protein (Met1-Arg53), N-GST tagged E.coli N-GST Met1-Arg53
Human CXCR3-261H Recombinant Human CXCR3 protein, His-tagged E.coli His 1-53 aa
Human CXCR3-717HF Recombinant Full Length Human CXCR3 Protein, GST-tagged In Vitro Cell Free System GST 368 amino acids
Human CXCR3-1082HFL Active Recombinant Human?CXCR3?Full Length Transmembrane protein, His&Flag-tagged(Detergent) HEK293 N-Flag & C-His Val 2 - Leu 368
Human CXCR3-758H Recombinant Human CXCR3 Full Length Transmembrane protein, Flag-tagged(Nanodisc) HEK293 Flag
Human Cxcr3-270M Active Recombinant Mouse CXCR3 Full Length Transmembrane protein(VLPs) HEK293 N/A Tyr 2 - Leu 367
Human CXCR3-718HF Recombinant Full Length Human CXCR3 Protein In Vitro Cell Free System 368 amino acids
Human CXCR3-279H Recombinant Human CXCR3 Full Length Transmembrane protein (1-368 aa), His-tagged E.coli N-His 1-368 aa
Mouse Cxcr3-2779M Recombinant Mouse Cxcr3 protein, His-KSI-tagged E.coli His-KSI 1-52aa
Rat CXCR3-1694R Recombinant Rat CXCR3 Protein Mammalian Cell His
Rat CXCR3-1353R Recombinant Rat CXCR3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Cxcr3-888R Recombinant Rat Cxcr3 Protein, His-tagged E.coli N-His Met1-Pro56+Asp111-Val125+Ser190-Gly222+Asp277-Ser300
Rat CXCR3-1353R-B Recombinant Rat CXCR3 Protein Pre-coupled Magnetic Beads HEK293
Bos taurus (Bovine) RFL31872BF Recombinant Full Length Bovine C-X-C Chemokine Receptor Type 3(Cxcr3) Protein, His-Tagged E.coli expression system His Full Length (1-366)
Canis lupus familiaris (Dog) (Canis familiaris) RFL31870CF Recombinant Full Length Dog C-X-C Chemokine Receptor Type 3(Cxcr3) Protein, His-Tagged E.coli expression system His Full Length (1-365)
Goat RFL7402CF Recombinant Full Length Goat C-X-C Chemokine Receptor Type 3(Cxcr3) Protein, His-Tagged E.coli expression system His Full Length (1-366)
Mus musculus (Mouse) RFL28829MF Recombinant Full Length Mouse C-X-C Chemokine Receptor Type 3(Cxcr3) Protein, His-Tagged E.coli expression system His Full Length (1-367)
Rattus norvegicus (Rat) RFL12193RF Recombinant Full Length Rat C-X-C Chemokine Receptor Type 3(Cxcr3) Protein, His-Tagged E.coli expression system His Full Length (1-367)
Rhesus Macaque CXCR3-1114R Recombinant Rhesus monkey CXCR3 Protein, His-tagged Mammalian Cell His
Rhesus Macaque CXCR3-939R-B Recombinant Rhesus Macaque CXCR3 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque CXCR3-939R Recombinant Rhesus Macaque CXCR3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Kit-0924 CYP1A2 Blue Screening Kit N/A
Kit-1040 FAD Colorimetric/Fluorometric Assay Kit N/A
Kit-1194 CXCR3 Activated GPCR Internalization Assay Kit N/A
Kit-1196 cAMP CXCR3 CHO-K1 GPCR Assay Kit N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

CXCR3 involved in several pathways and played different roles in them. We selected most pathways CXCR3 participated on our site, such as Cytokine-cytokine receptor interaction, Chemokine signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CXCR3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cytokine-cytokine receptor interactionIL11RA2;CCR9;IL6R;TNFRSF17;GH1;AMH;LOC100033925;IL1B;CX3CR1
Chemokine signaling pathwayCCR6;GNGT2;IKBKB;GNG4;CCL4L2;PARD3;CCL2;GM13306;GNG8

CXCR3 has several biochemical functions, for example, C-X-C chemokine binding, C-X-C chemokine receptor activity, chemokine binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CXCR3 itself. We selected most functions CXCR3 had, and list some proteins which have the same functions with CXCR3. You can find most of the proteins on our site.

Function Related Protein
C-X-C chemokine bindingCXCR6;CXCR3;HMGB1;CXCR7
C-X-C chemokine receptor activityCXCR6;CCR9A;CXCR3;CXCR2;CXCR7;CXCR4;CXCR4B;CCBP2;CXCR4A
chemokine bindingPLP2;ACKR4;ACKR3B;CXCR3
chemokine receptor activityRGRA;CCR8;CCR3;RGRB;CCR5;CX3CR1;CCR1;CCR9A;GPR17
receptor activityITGB3B;EXTL3;NR2C2;CCR6;NOTCH1;GRIN1A;BTN1A1;RAMP3;MED30

CXCR3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CXCR3 here. Most of them are supplied by our site. Hope this information will be useful for your research of CXCR3.

Gene Family

GPCRs Chemokines Cytokines

Research Area

Related articles

Tan, JF; Jin, XF; et al. Beneficial effect of T follicular helper cells on antibody class switching of B cells in prostate cancer. ONCOLOGY REPORTS 33:1512-1518(2015).
Wang, J; Vodovotz, Y; et al. Injury-induced MRP8/MRP14 stimulates IP-10/CXCL10 in monocytes/macrophages. FASEB JOURNAL 29:250-262(2015).
  • Q&As
  • Reviews

Q&As (7)

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What is the primary role of chemokines and their receptors, particularly CXCR3, in immune cell processes? 10/18/2020

The primary role of chemokines and their receptors, including CXCR3, is in the recruitment, activation, and differentiation of immune cells.

How many variant isoforms of CXCR3 exist, and what are their names? 03/20/2020

There are three variant isoforms of CXCR3: CXCR3A, CXCR3B, and CXCR3alt.

Which ligands are associated with the chemokine receptor CXCR3, and what are their roles during interferon-induced inflammatory responses? 01/18/2019

The ligands associated with the chemokine receptor CXCR3 are CXCL9, CXCL10, and CXCL11, and they play key roles during interferon-induced inflammatory responses.

What aspect of the inflammatory process in human skin involving CXCR3 chemokines and isoforms requires further investigation, according to the information provided? 12/18/2018

The relative contributions of different CXCR3 chemokines and the three variant isoforms to the inflammatory process in human skin require further investigation.

What is the focus of the review regarding CXCR3, its ligands, and their role in skin during inflammation and carcinogenesis? 05/16/2018

The review focuses on the biology of CXCR3 and its associated ligands, with particular emphasis on their roles in the skin during inflammation and carcinogenesis.

In the context of skin cancers, what dual role can the CXCR3 receptor play, and how does its expression on different cell types contribute to cancer outcomes? 01/14/2018

In skin cancers, the CXCR3 receptor can play a dual role. Its expression on tumor cells can lead to cancer metastasis, while expression on immune cells can promote anti-tumor immune responses.

What drives the expression of CXCL9, CXCL10, and CXCL11, and what is their function in recruiting CXCR3+ T cells during skin inflammation? 11/27/2016

The expression of CXCL9, CXCL10, and CXCL11 is driven by inflammation of the skin resulting from infections or autoimmune disease, leading to the recruitment of effector, CXCR3+ T cells from the circulation.

Customer Reviews (3)

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Reviews
12/11/2019

    The continuous innovation and improvements made by the manufacturer indicated a promising future for the product.

    07/30/2019

      Inclusion of the product consistently led to a significant upregulation of target protein expression levels.

      12/19/2016

        We were excited about the product's role in driving future discoveries in our field of study.

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