Recombinant Human CXCR3 protein, GST-tagged

Cat.No. : CXCR3-16H
Product Overview : Recombinant Human CXCR3(1 a.a. - 368 a.a.) fused with GST tag at N-terminal was expressed in Wheat Germ.
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Description : This gene encodes a G protein-coupled receptor with selectivity for three chemokines, termed CXCL9/Mig (monokine induced by interferon-g), CXCL10/IP10 (interferon-g-inducible 10 kDa protein) and CXCL11/I-TAC (interferon-inducible T cell a-chemoattractant). Binding of chemokines to this protein induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the isoforms (CXCR3-B) shows high affinity binding to chemokine, CXCL4/PF4 (PMID:12782716).
Source : Wheat Germ
Species : Human
Tag : GST
Form : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Molecular Mass : 67.1 kDa
AA Sequence : MVLEVSDHQVLNDAEVAALLENFSS SYDYGENESDSCCTSPPCPQDFSLN FDRAFLPALYSLLFLLGLLGNGAVA AVLLSRRTALSSTDTFLLHLAVADT LLVLTLPLWAVDAAVQWVFGSGLCK VAGALFNINFYAGALLLACISFDRY LNIVHATQLYRRGPPARVTLTCLAV WGLCLLFALPDFIFLSAHHDERLNA THCQYNFPQVGRTALRVLQLVAGFL LPLLVMAYCYAHILAVLLVSRGQRR LRAMRLVVVVVVAFALCWTPYHLVV LVDILMDLGALARNCGRESRVDVAK SVTSGLGYMHCCLNPLLYAFVGVKF RERMWMLLLRLGCPNQRGLQRQPSS SRRDSSWSETSEASYSGL
Applications : Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array
Notes : Best use within three months from the date of receipt of this protein.
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Gene Name : CXCR3 chemokine (C-X-C motif) receptor 3 [ Homo sapiens ]
Official Symbol : CXCR3
Synonyms : CXCR3; chemokine (C-X-C motif) receptor 3; G protein coupled receptor 9 , GPR9; C-X-C chemokine receptor type 3; CD183; CKR L2; CMKAR3; IP10 R; MigR; CXC-R3; CXCR-3; Mig receptor; IP10 receptor; IP-10 receptor; G protein-coupled receptor 9; chemokine (C-X-C) receptor 3; interferon-inducible protein 10 receptor; GPR9; CD182; Mig-R; CKR-L2; IP10-R;
Gene ID : 2833
mRNA Refseq : NM_001504
Protein Refseq : NP_001495
MIM : 300574
UniProt ID : P49682
Chromosome Location : Xq13
Pathway : CXCR3-mediated signaling events, organism-specific biosystem; Chemokine receptors bind chemokines, organism-specific biosystem; Chemokine signaling pathway, organism-specific biosystem; Chemokine signaling pathway, conserved biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem;
Function : C-X-C chemokine receptor activity; G-protein coupled receptor activity; chemokine binding; chemokine receptor activity; receptor activity; signal transducer activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Customer Reviews (3)

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Reviews
12/11/2019

    The continuous innovation and improvements made by the manufacturer indicated a promising future for the product.

    07/30/2019

      Inclusion of the product consistently led to a significant upregulation of target protein expression levels.

      12/19/2016

        We were excited about the product's role in driving future discoveries in our field of study.

        Q&As (7)

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        What is the primary role of chemokines and their receptors, particularly CXCR3, in immune cell processes? 10/18/2020

        The primary role of chemokines and their receptors, including CXCR3, is in the recruitment, activation, and differentiation of immune cells.

        How many variant isoforms of CXCR3 exist, and what are their names? 03/20/2020

        There are three variant isoforms of CXCR3: CXCR3A, CXCR3B, and CXCR3alt.

        Which ligands are associated with the chemokine receptor CXCR3, and what are their roles during interferon-induced inflammatory responses? 01/18/2019

        The ligands associated with the chemokine receptor CXCR3 are CXCL9, CXCL10, and CXCL11, and they play key roles during interferon-induced inflammatory responses.

        What aspect of the inflammatory process in human skin involving CXCR3 chemokines and isoforms requires further investigation, according to the information provided? 12/18/2018

        The relative contributions of different CXCR3 chemokines and the three variant isoforms to the inflammatory process in human skin require further investigation.

        What is the focus of the review regarding CXCR3, its ligands, and their role in skin during inflammation and carcinogenesis? 05/16/2018

        The review focuses on the biology of CXCR3 and its associated ligands, with particular emphasis on their roles in the skin during inflammation and carcinogenesis.

        In the context of skin cancers, what dual role can the CXCR3 receptor play, and how does its expression on different cell types contribute to cancer outcomes? 01/14/2018

        In skin cancers, the CXCR3 receptor can play a dual role. Its expression on tumor cells can lead to cancer metastasis, while expression on immune cells can promote anti-tumor immune responses.

        What drives the expression of CXCL9, CXCL10, and CXCL11, and what is their function in recruiting CXCR3+ T cells during skin inflammation? 11/27/2016

        The expression of CXCL9, CXCL10, and CXCL11 is driven by inflammation of the skin resulting from infections or autoimmune disease, leading to the recruitment of effector, CXCR3+ T cells from the circulation.

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