Recombinant Full Length Goat C-X-C Chemokine Receptor Type 3(Cxcr3) Protein, His-Tagged
Cat.No. : | RFL7402CF |
Product Overview : | Recombinant Full Length Goat C-X-C chemokine receptor type 3(CXCR3) Protein (Q867B2) (1-366aa), fused to N-terminal His tag, was expressed in E. coli. |
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Source : | E.coli expression system |
Species : | Capra hircus (Goat) |
Tag : | His |
Form : | Lyophilized powder |
Protein length : | Full Length (1-366) |
AA Sequence : | MVPEMSERQEFQASEFAYLLENSSY DYGENETYFCCTSPPCPQDFSLNFD RTFLPVLYSL LFVLGLLGNGVVAVVLLSQRAALSS TDTFLLHLAVADALLVLTLPLWAVD AAIQWVFGSG LCKVAGALFNINFYAGALLLACISF DRYLSIVHATQFYRRGPPARVALTC VAVWGLCLLF ALPDFIFLSSHHDNRLNATHCQYNF PQEGRTALRVLQLVAGFLLPLLVMA YCYARILTVL LVSRGQRRLRAMRLVVVVVVAFALC WTPYHLVVLVDTLMDLGALARNCGR ESRVDVAKSV TSGMGYMHCCLNPLLYAFVGVKFRE RMWVLLMRLGCPDQRGHQRQPSASR RDSSWSETTE ASYSGL |
Purity : | Greater than 90% as determined by SDS-PAGE. |
Notes : | Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week. |
Storage : | Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles. |
Storage Buffer : | Tris/PBS-based buffer, 6% Trehalose, pH 8.0 |
Reconstitution : | We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference. |
Gene Name : | CXCR3 |
Synonyms : | CXCR3; C-X-C chemokine receptor type 3; CXC-R3; CXCR-3; Interferon-inducible protein 10 receptor; IP-10 receptor; CD antigen CD183 |
UniProt ID : | Q867B2 |
Gene Name : | CXCR3 |
Synonyms : | CXCR3; C-X-C chemokine receptor type 3; CXC-R3; CXCR-3; Interferon-inducible protein 10 receptor; IP-10 receptor; CD antigen CD183 |
UniProt ID : | Q867B2 |
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◆ Lysates | ||
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◆ Assay kits | ||
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Customer Reviews (3)
Write a reviewThe continuous innovation and improvements made by the manufacturer indicated a promising future for the product.
Inclusion of the product consistently led to a significant upregulation of target protein expression levels.
We were excited about the product's role in driving future discoveries in our field of study.
Q&As (7)
Ask a questionThe primary role of chemokines and their receptors, including CXCR3, is in the recruitment, activation, and differentiation of immune cells.
There are three variant isoforms of CXCR3: CXCR3A, CXCR3B, and CXCR3alt.
The ligands associated with the chemokine receptor CXCR3 are CXCL9, CXCL10, and CXCL11, and they play key roles during interferon-induced inflammatory responses.
The relative contributions of different CXCR3 chemokines and the three variant isoforms to the inflammatory process in human skin require further investigation.
The review focuses on the biology of CXCR3 and its associated ligands, with particular emphasis on their roles in the skin during inflammation and carcinogenesis.
In skin cancers, the CXCR3 receptor can play a dual role. Its expression on tumor cells can lead to cancer metastasis, while expression on immune cells can promote anti-tumor immune responses.
The expression of CXCL9, CXCL10, and CXCL11 is driven by inflammation of the skin resulting from infections or autoimmune disease, leading to the recruitment of effector, CXCR3+ T cells from the circulation.
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